The dynamic relationship between COVID-19 cases and SARS-CoV-2 wastewater concentrations across time and space: Considerations for model training data sets

The Science of The Total Environment, Год журнала: 2023, Номер 871, С. 162069 - 162069

Опубликована: Фев. 7, 2023

During the COVID-19 pandemic, wastewater-based surveillance has been used alongside diagnostic testing to monitor infection rates. With decline in cases reported public health departments due at-home testing, wastewater data may serve as primary input for epidemiological models, but training these models is not straightforward. We explored factors affecting noise and bias ratio between case collected 26 sewersheds California from October 2020 March 2022. The strength of relationship appeared dependent on sampling frequency population size, was increased by normalization flow rate or count Additionally, lead lag times varied over time space, log-transformed individual concentrations changed time. This decreased Epsilon/Alpha Delta variant surges during Omicron BA.1 surge, also related rate. Based this analysis, we present a framework scenarios describing dynamics aid handling decisions ongoing modeling efforts.

Язык: Английский

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Divergence of wastewater SARS-CoV-2 and reported laboratory-confirmed COVID-19 incident case data coincident with wide-spread availability of at-home COVID-19 antigen tests

PeerJ, Год журнала: 2023, Номер 11, С. e15631 - e15631

Опубликована: Июнь 27, 2023

Concentrations of SARS-CoV-2 RNA in wastewater settled solids from publicly owned treatment works (POTWs) historically correlated strongly with laboratory confirmed incident COVID-19 case data. With the increased availability at-home antigen tests since late 2021 and early 2022, test seeking behavior has decreased. In United States, results are not typically reportable to public health agencies thus counted reports. As a result, number reported laboratory-confirmed cases decreased dramatically, even during times positivity rates concentrations RNA. Herein, we tested whether correlative relationship between incidence rate changed 1 May point time immediately before onset BA.2/BA.5 surge, first surge begin after was high region. We used daily data three POTWs Greater San Francisco Bay Area California, USA for analysis. found that although there is significant positive association measurements collected parameters describing different than those prior 2022. If or continues change, will continue change. Our suggest, assuming shedding remains relatively stable among infected virus as variants emerge, can be estimate they would have been when testing were at (here, 2022) using historical

Язык: Английский

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Human pathogen nucleic acids in wastewater solids from 191 wastewater treatment plants in the United States

Scientific Data, Год журнала: 2024, Номер 11(1)

Опубликована: Окт. 17, 2024

We measured concentrations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, influenza A B viruses, syncytial virus, human metapneumovirus, enterovirus D68, parainfluenza types 1, 2, 3, 4a, 4b in aggregate, norovirus genotype II, rotavirus, Candida auris, hepatitis adenovirus, mpox H5 pepper mild mottle virus nucleic acids wastewater solids prospectively at 191 treatment plants 40 states across the United States plus Washington DC. Measurements were made two to seven times per week from 1 January 2022 30 June 2024, depending on plant staff availability. using droplet digital (reverse-transcription-) polymerase chain reaction (ddRT-PCR) following best practices for making environmental molecular biology measurements. These data can be used better understand disease occurrence communities contributing wastewater.

Язык: Английский

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Wastewater pandemic preparedness: Toward an end-to-end pathogen monitoring program

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Март 21, 2023

Molecular analysis of public wastewater has great potential as a harbinger for community health and threats. Long-used to monitor the presence enteric viruses, in particular polio, recent successes reliable lead indicator trends SARS-CoV-2 levels hospital admissions generated optimism emerging evidence that similar science can be applied other pathogens pandemic (PPPs), especially respiratory viruses their variants concern (VOC). However, there are substantial challenges associated with implementation this ideal, namely multiple distinct fields inquiry must bridged coordinated. These include engineering, molecular sciences, temporal-geospatial analytics, epidemiology medical, governmental messaging, all which present own caveats. Here, we outline framework an integrated, state-wide, end-to-end human pathogen monitoring program using track viral PPPs.

Язык: Английский

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Emergence and spread of SARS-CoV-2 variants of concern in Canada: a retrospective analysis from clinical and wastewater data

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 29, 2024

Abstract Background The spread of SARS-CoV-2 has been studied at unprecedented levels worldwide. In jurisdictions where molecular analysis was performed on large scales, the emergence and competition numerous SARS-CoV-2lineages have observed in near real-time. Lineage identification, traditionally from clinical samples, can also be determined by sampling wastewater sewersheds serving populations interest. Variants concern (VOCs) lineages associated with increased transmissibility and/or severity are particular Method Here, we consider data sources to assess VOCs Canada retrospectively. Results We show that, overall, wastewater-based VOC identification provides similar insights surveillance based samples. Based data, synchrony introduction as well speeds across most Canadian provinces despite geographical size country differences provincial public health measures. Conclusion particular, it took approximately four months for Alpha Delta contribute half incidence. contrast, Omicron achieved same contribution less than one month. This study significant benchmarks enhance planning future VOCs, some extent pandemics caused other pathogens, quantifying rate invasion Canada.

Язык: Английский

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Wastewater-based epidemiology for COVID-19 surveillance and beyond: A survey

Epidemics, Год журнала: 2024, Номер 49, С. 100793 - 100793

Опубликована: Сен. 26, 2024

Язык: Английский

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Passive swab versus grab sampling for detection of SARS-CoV-2 markers in wastewater

The Science of The Total Environment, Год журнала: 2023, Номер 889, С. 164180 - 164180

Опубликована: Май 16, 2023

Язык: Английский

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Public Health Interventions Guided by Houston’s Wastewater Surveillance Program During the COVID-19 Pandemic

Public Health Reports, Год журнала: 2023, Номер 138(6), С. 856 - 861

Опубликована: Июль 28, 2023

Since the start of COVID-19 pandemic, wastewater surveillance has emerged as a powerful tool used by public health authorities to track SARS-CoV-2 infections in communities. In May 2020, Houston Health Department began working with coalition municipal and academic partners develop monitoring reporting system for city Houston, Texas. Data collected from are integrated other data communicated through different channels local general public. This information is shape policies inform actions mitigate prevent spread at municipal, institutional, individual levels. Based on success this drive protection efforts, program likely become standard part toolkit responding infectious diseases and, potentially, disease-causing outbreaks.

Язык: Английский

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Identifying spatiotemporal trends of SARS-CoV-2 RNA in wastewater: from the perspective of upstream and downstream wastewater-based epidemiology (WBE)

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(8), С. 11576 - 11590

Опубликована: Янв. 14, 2024

Язык: Английский

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Temporal assessment of SARS-CoV-2 detection in wastewater and its epidemiological implications in COVID-19 case dynamics

Heliyon, Год журнала: 2024, Номер 10(8), С. e29462 - e29462

Опубликована: Апрель 1, 2024

This research evaluated the relationship between daily new Coronavirus Disease 2019 (COVID-19) cases and Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) concentrations in wastewater, followed by effects of differential SARS-CoV-2 shedding loads across various COVID-19 outbreaks. Linear regression analyses were utilized to examine lead time signal wastewater relative clinical cases. During Delta wave, no was evident, highlighting limited predictive capability monitoring during this phase. However, significant times observed Omicron potentially attributed testing capacity overload subsequent case reporting delays or changes patterns. Post-Omicron wave (Febuary 23 May 19, 2022), discernible, whereas following lifting state emergency (May 30, 2022 2023), correlation coefficient increased demonstrated potential surveillance as an early warning system. Subsequently, we explored virus through feces, operationalized ratio varied significantly Delta, Omicron, other variants post-state-emergency phases, with Kruskal-Wallis H test confirming a difference medians these stages (P < 0.0001). Despite its promise, disease prevalence presents several challenges, including variability, data interpretation complexity, impact environmental factors on viral degradation, lack standardized procedures. Overall, our findings offer insights into concentrations, variation different pandemic underscore promise limitations system for trends.

Язык: Английский

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