The
increasing
number
of
deaths
caused
by
mosquito-borne
diseases
highlights
the
need
to
produce
efficient
and
environmentally
sustainable
alternatives.
aim
present
investigation
we
have
utilized
leaf
from
Laureliopsis
philippiana
(LP)
synthesize
silver
(Ag)
palladium
(Pd)
nanoparticles
(NPs)
studied
toxicity
on
deadly
disease
vectors
larvae
Aedes
aegypti
Anopheles
stephensi.
Biosynthesized
Ag
Pd
NPs
were
investigated
UV-Vis
spectroscopy,
Fourier
transform
infrared
(FT-IR),
X-Ray
Diffraction
(XRD),
Transmission
electron
microscopy
(TEM),
Zeta
potential
analysis.
GC-MS
analysis
L.
assisted
in
identifying
secondary
metabolites
extract's
total
flavonoid
phenolic
compounds,
which
are
reactants
bio-reduction
process
during
production
nanoparticles.
in-silico
was
conducted
mosquito
sterol
carrier
protein-2
(1PZ4)
odorant
binding
protein
(2L2C).
XRD
results
revealed
crystalline
structure
NPs.
At
same
time,
TEM
representation,
biosynthesized
spherical,
clustered,
exhibited
a
noticeable
UV
peak
at
417
370
nm
(average
size
AgNPs:
13.25±
2.53
PdNPs:
4.07±
1.64
nm).
biogenic
concentration-dependent
larvicidal
effect
with
LC50
values
29.596,
17.804,
23.915,
14.878
µg/mL
Ae.
23.946,
13.938,
19.457,
12.876
against
An.
stephensi,
correspondingly.
In-silico
studies
proved
that
Laureliopsine
A
(-7.6
-8.4
kcal/mol)
isoterpinolene
(-7.0
-6.7
showed
significant
docking
scores
comparison
permethrin
(-5.3
-8.0
kcal/mol),
proteins
(1PZ4
2L2C).
Besides,
LP-Ag
non-toxicity
carried
out
Zebrafish
embryos
72h
post-fertilization.
Overall,
findings
clearly
demonstrated
green
synthesized
develop
secure
safe
larvicides.
Green Chemistry Letters and Reviews,
Год журнала:
2024,
Номер
17(1)
Опубликована: Фев. 2, 2024
This
study
aimed
to
synthesize
silver
nanoparticles
(VJ@AgNPs)
using
Valeriana
jatamansi
root
extract
and
assess
their
antibacterial,
antioxidant,
antibiofilm
properties
against
Escherichia
coli,
Staphylococcus
aureus,
Streptococcus
mutans.
Various
chemical
physical
characterization
methods
were
employed
analyze
the
synthesized
VJ@AgNPs.
UV-Visible
spectroscopy
confirmed
presence
of
VJ@AgNPs
with
a
peak
absorption
at
426
nm,
while
FT-IR
results
indicated
involvement
phyto-compounds
from
V.
in
reduction
stabilization
these
nanoparticles.
High-resolution
transmission
electron
microscopy
revealed
well-dispersed
spherical
nature
an
average
size
29.1
±
2.06
X-ray
diffraction
crystalline
structure.
The
biosynthesized
exhibited
significant
antibacterial
activity
all
tested
pathogens,
substantial
inhibition
zones
50
100
μg/mL
concentrations.
Additionally,
displayed
potent
antioxidant
capacity
scavenging
assays.
Furthermore,
showed
promise
photocatalytic
degradation,
effectively
removing
95%
RhB
dye
within
75
minutes
under
solar
light
irradiation,
following
pseudo-first-order
kinetics.
suggests
potential
application
wastewater
treatment
for
organic
removal.
biocompatible
environmentally
friendly
underscores
as
therapeutic
agents
bacterial
infections
oxidative
stress-related
diseases.
Toxics,
Год журнала:
2023,
Номер
11(6), С. 517 - 517
Опубликована: Июнь 8, 2023
Bio-insecticidal
research
has
focused
on
long-term
vector
control
using
essential
oils
(EOs).
This
study
examined
the
larvicidal,
oviposition-deterrent,
and
repellent
properties
of
five
medicinal
herb-based
EO
formulations
(EOFs)
mosquitoes
that
are
vectors
dengue,
filariasis,
malaria.
EOFs
were
significantly
more
toxic
to
larvae
pupae
Culex
quinquefasciatus,
Anopheles
stephensi,
Aedes
aegypti
with
LC50
=
9.23,
12.85,
14.46
ppm,
as
well
10.22,
11.39,
12.81
oviposition
active
indexes
-0.84,
-0.95,
-0.92,
respectively.
Oviposition-deterrent
repellence
was
found
in
91.39%,
94.83%,
96.09%.
EOs
N,
N-Diethyl-3-methylbenzamide
(DEET)
prepared
at
various
concentrations
for
time
duration
bioassays
(6.25-100
ppm).
Ae.
aegypti,
An.
Cx.
quinquefasciatus
monitored
300,
270,
180
min,
At
100
DEET
had
comparable
terms
test
durations.
EOF's
primary
components
d-limonene
(12.9%),
2,6-octadienal,
3,7-dimethyl,
(Z)
(12.2%),
acetic
acid,
phenylmethyl
ester
(19.6%),
verbenol
(7.6%),
benzyl
benzoate
(17.4%)
may
be
combined
make
a
mosquito
larvicidal
repellant
equivalent
synthetic
lotions.
In
molecular
dynamics
simulations,
limonene
(-6.1
kcal/mol)
(-7.5
positive
chemical
association
(-6.3
interacted
OBP
binding
pocket
high
affinity
stability.
will
help
local
herbal
product
manufacturers
cosmetics
industry
developing
100%
insect
products
combat
mosquito-borne
diseases,
including
malaria,
filariasis.
