Thallium’s Threat to Aquatic Life: Stage-Specific Toxicity in Zebrafish Embryos and Larvae

Environment & Health, Год журнала: 2024, Номер 2(3), С. 114 - 125

Опубликована: Фев. 7, 2024

The escalating frequency of thallium (Tl) contamination incidents amplifies its environmental risk. However, the potential risk Tl to aquatic organisms, especially across varying developmental stages, remains poorly understood. In this study, we employed zebrafish as a representative model organism and exposed embryos larvae at distinct periods (specifically, 6 h postfertilization (hpf) 72 hpf) low concentrations Tl(I) (0.25 0.50 mg/L). exposure was performed for short duration 24 h, followed by 96 depuration period. Our results revealed that exerted disparate biological effects on different stages. Embryos exhibited negligible uptake Tl(I), whereas showed significant accumulation struggled with rapid elimination. Notably, able permeate blood-brain barrier, thereby posing nervous system. Transcriptomic analysis indicated triggered toxicological pathways in larvae. It mainly interfered metabolic processes embryos, while larvae, it disrupted intracellular ion homeostasis, both consequently provoking neurotoxicity. This emphasizes multifaceted nature toxicity depends stages organism. study clearly shows bioeffects are intricately related stage zebrafish, offering valuable perspective pollutant assessment.

Язык: Английский

---

Dietary carvacrol essential oil alleviates thallium nitrate-induced toxicity in Oreochromis niloticus: Growth, hepatorenal, oxidative stress, gene expression, and histopathological study

Aquaculture, Год журнала: 2025, Номер unknown, С. 742175 - 742175

Опубликована: Янв. 1, 2025

Язык: Английский

---

Persistent effects of early-life exposure to dibutyl phthalate on zebrafish: Immune system dysfunction via HPA axis

Environment International, Год журнала: 2025, Номер 198, С. 109386 - 109386

Опубликована: Март 16, 2025

Язык: Английский

---

Effects of butyl benzyl phthalate on zebrafish (Danio rerio) brain and the underlying molecular mechanisms revealed by transcriptome analysis

The Science of The Total Environment, Год журнала: 2023, Номер 906, С. 167659 - 167659

Опубликована: Окт. 7, 2023

Язык: Английский

---

Histology and transcriptomic analysis reveal the inflammation and affected pathways under 2-methylisoborneol (2-MIB) exposure on grass carp

The Science of The Total Environment, Год журнала: 2024, Номер 938, С. 173233 - 173233

Опубликована: Май 17, 2024

Язык: Английский

---

A comparative study on the toxic effects of lead pollution and nanoplastic-lead mixed pollution on red drum and their detoxification strategies

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136018 - 136018

Опубликована: Окт. 2, 2024

Язык: Английский

---

Synergistic integration of transcriptomics and metabolomics analyses provides novel insights into the mechanisms underlying unsynchronized growth of greater amberjack (Seriola dumerili)

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Год журнала: 2025, Номер 54, С. 101441 - 101441

Опубликована: Фев. 9, 2025

Язык: Английский

---

2,3,4-Trihydroxybenzophenone-induced cardiac and neurological toxicity: Heart-brain interaction mediated by regulation of pgam1a and pgk1 involved in glycolysis and gluconeogenesis in zebrafish

The Science of The Total Environment, Год журнала: 2025, Номер 974, С. 179212 - 179212

Опубликована: Март 30, 2025

Язык: Английский

---

Why Western Mosquitofish (Gambusia affinis) Is Tolerant to Se Contamination: Complex Mechanistic Explanations

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

The western mosquitofish (Gambusia affinis (G. affinis)) is often the only fish that survives in various selenium-contaminated aquatic environments. However, mechanisms of its survival such environments remain seldom explored. In this study, acute toxicity selenomethionine (Se-Met) a variety species (four oviparous and four ovoviviparous species) was evaluated, followed by chronic effects Se-Met on G. zebrafish (Danio rerio (D. rerio)), focusing Se accumulation gonads offspring, reproductive biology, offspring development. Our results showed LC50-96h largest among eight fish, confirming elevated resistance to Se. Meanwhile, transcripts genes related selenoproteins sulfoproteins opposite responses between D. exposure, along with altered levels total but not fish. exposures gonads, gonadal development embryonic early larval development, efflux embryos larvae were apparently different rerio. Finally, differentially expressed (particularly antioxidant inflammation) mostly stimulated inhibited This study has demonstrated capacity metabolism physiology can help partially explain Se-contaminated ecosystems.

Язык: Английский

---

Thallium-induced neurocardiotoxicity in zebrafish: Protective role of adaptive UPR and DNA repair

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 298, С. 118321 - 118321

Опубликована: Май 14, 2025

Язык: Английский

---