Early-life risk factors, accelerated biological aging and the late-life risk of mortality and morbidity

QJM, Год журнала: 2023, Номер 117(4), С. 257 - 268

Опубликована: Ноя. 1, 2023

Summary Background Early-life exposure increases health risks throughout an individual’s lifetime. Biological aging is influenced by early-life as a key process of disease development, but whether could accelerate biological and elevate late-life mortality morbidity remains unknown. Knowledge also limited on the potential moderating role healthy lifestyle. Methods We investigate associations three around birth, breastfeeding, maternal smoking birth weight, with 202 580 UK Biobank participants (54.9 ± 8.1 years old). was quantified KDM-BA, PhenoAge frailty. Moderate alcohol intake, no current smoking, diet, BMI <30 kg/m2 regular physical activity were considered lifestyles. Mortality data retrieved from records. Results Individual risk factors robustly associated accelerated aging. A one-unit increase in ‘early-life score’ integrating 0.060 (SE=0.0019) 0.036-unit (SE = 0.0027) z-scored KDM-BA acceleration acceleration, respectively, 22.3% higher odds (95% CI: 1.185–1.262) Increased chronological age lifestyles mitigate accelerations PhenoAge, respectively. Associations score mediated (proportions: 5.66–43.12%). significantly mediate impact most outcomes except anxiety, frailty not T2D. Conclusion capture stemming risks, be potentially targeted for longevity promotion.

Язык: Английский

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Threshold and combined effects of heavy metals on the risk of phenotypic age acceleration among U.S. adults

BioMetals, Год журнала: 2024, Номер 37(5), С. 1279 - 1288

Опубликована: Май 31, 2024

Язык: Английский

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Associations of multiple serum metals with the risk of metabolic syndrome among the older population in China based on a community study: A mediation role of peripheral blood cells

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 116981 - 116981

Опубликована: Сен. 3, 2024

Metal exposure has been reported to be associated with metabolic syndrome (MetS), however, the evidence remains inconclusive, particularly in elderly individuals. From May July 2016, serum levels of 16 metals were measured using inductively coupled plasma mass spectrometry (ICP-MS) 852 individuals (≥65 years) residing Wuhan, China. Biological detection and disease recognition based on individual surveys conducted during health check-ups. Spearman's rank correlation analysis was performed identify among metals. The data Ln-transformed fit a normal distribution for further analyses. Linear logistic regression applied explore associations between diseases. Restricted cubic spline (RCS) utilized examine dose-response relationships. Weighted Quantile Sum (WQS) score determine empirical weights each heavy metal context their combined effect prevalence MetS, hypertension, diabetes, hyperlipidemia 46.36 %, 68.90 24.65 21.60 respectively. Serum mixture positively MetS (OR = 1.92, 95 % CI: 1.30-2.82), hypertension 1.50, 1.01-2.23), diabetes 2.18, 1.48-3.22). In single models, we found that zinc an increased risk while rubidium had protective against MetS. Interestingly, different distinct effects specific diseases this study: lithium barium more likely influence blood pressure, selenium significant glucose. Lipids susceptible zinc, selenium, strontium. Platelet count (PLT) lymphocyte (LYM) mediated association hyperlipidemia, neutrophil (NEU) relationship Our findings offer valuable etiological insights into suggesting peripheral cells may play mediating role association.

Язык: Английский

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Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Exposure to toxic metals might accelerate aging

Environmental Research, Год журнала: 2025, Номер unknown, С. 121180 - 121180

Опубликована: Фев. 1, 2025

Язык: Английский

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Biological age construction for prediction of mortality in the Chinese population

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Язык: Английский

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Associations between serum trace elements and biological age acceleration in the Chinese elderly: A community-based study investigating the mediating role of inflammatory markers and the moderating effect of physical activity

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138273 - 138273

Опубликована: Апрель 1, 2025

Язык: Английский

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Dietary Diversity Modified the Association of Per- and Polyfluoroalkyl Substances with Accelerated Biological Aging: Evidence from the China National Human Biomonitoring Study

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Per- and polyfluoroalkyl substances (PFASs) can impact various systems in the human body. However, their influence on biological aging remains unclear. This study aims to investigate association between PFASs exposure based data from 9756 participants China National Human Biomonitoring Program assesses potential moderating effect of Dietary Diversity Score (DDS). Biological age indexes were calculated using Klemera-Doubal method (KDM) Mahalanobis distance (MD). The DDS was consumption frequency 13 food groups over past 12 months. Most showed positive associations with KDM-age acceleration (KDM-AA), while no statistically significant observed MD. dose-response relationships KDM-AA MD steeper at low concentrations PFASs, then slope appeared flat higher concentrations. weighted quantile sum revealed mixture effects aging. PFHpS PFNA both major contributors potentially modify Our findings demonstrate that significantly associated accelerated aging, whereas mitigates these adverse effects, highlighting importance this preventive measure.

Язык: Английский

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Biological aging mediates the associations between urinary metals and hypertension: Insights from cross-sectional studies on Chinese and American adults

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Accelerated Biological Aging, Genetic Susceptibility, and Non-Alcoholic Fatty Liver Disease: Two Prospective Cohort Studies

Nutrients, Год журнала: 2025, Номер 17(10), С. 1618 - 1618

Опубликована: Май 8, 2025

Background: Biological aging is considered a vital risk factor for age-related diseases, but its role in non-alcoholic fatty liver disease (NAFLD) remains uncertain. This study aimed to evaluate the associations of biological with NAFLD and modified effect genetic susceptibility. Methods: included 329,040 participants from UK Biobank 6783 Dongfeng–Tongji Cohort China. We calculated chronological age-adjusted age as surrogate measure aging. Accelerated was defined that exceeded age. The association between assessed two cohorts. Polygenic scores (PRSs) were used determine susceptibility further analyze interaction Results: In Biobank, one year older increased prevalent by 6%. hazard ratios (HRs) 95% confidence intervals (95% CIs) accelerated 1.35 (1.17, 1.56) 1.69 (1.54, 1.85) compared non-aging. Cohort, prospectively associated (accelerated aging: odds ratio (OR) CI) = 1.18 (1.03, 1.36)). high significantly higher low (HRs 1.65 (1.40, 1.95)). Analyses joint effects showed PRS had highest [2.66 (2.98, 3.57) 2.06 (2.36, 3.96)]. However, among regardless risk. There no significant Conclusions: independent Identifying populations use measures timely intervention may be beneficial prevention NAFLD.

Язык: Английский

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