Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

The Science of The Total Environment, Год журнала: 2023, Номер 871, С. 161962 - 161962

Опубликована: Фев. 10, 2023

Язык: Английский

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Health risk of human exposure to microplastics: a review

Environmental Chemistry Letters, Год журнала: 2024, Номер 22(3), С. 1155 - 1183

Опубликована: Март 25, 2024

Язык: Английский

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Cadmium exposure caused cardiotoxicity in common carps (Cyprinus carpio L.): miR-9-5p, oxidative stress, energetic impairment, mitochondrial division/fusion imbalance, inflammation, and autophagy

Fish & Shellfish Immunology, Год журнала: 2023, Номер 138, С. 108853 - 108853

Опубликована: Май 27, 2023

Язык: Английский

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Micro/nano-plastics impacts in cardiovascular systems across species

The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173770 - 173770

Опубликована: Июнь 7, 2024

Язык: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

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EGCG alleviated Mn exposure-caused carp kidney damage via trpm2-NLRP3-TNF-α-JNK pathway: Oxidative stress, inflammation, and tight junction dysfunction

Fish & Shellfish Immunology, Год журнала: 2023, Номер 134, С. 108582 - 108582

Опубликована: Фев. 7, 2023

Язык: Английский

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Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(14), С. 5450 - 5462

Опубликована: Апрель 3, 2023

Perfluorooctanesulfonic acid (PFOS), a fluorine-containing organic compound, can be widely detected in the environment and living organisms. Accumulating evidence has shown that PFOS breaks through different biological barriers resulting cardiac toxicity, but underlying molecular mechanisms remain unclear. Cannabidiol (CBD) is nonpsychoactive cannabinoid without potential adverse cardiotoxicity antioxidant anti-inflammatory properties reduce multiorgan damage dysfunction. For these reasons, aim of this study was to research how caused heart injury whether CBD could attenuate PFOS-induced injury. Mice were fed (5 mg/kg) and/or (10 vivo. In vitro, H9C2 cells intervened with (200 μM) μM). After exposure, oxidative stress levels mRNA protein expression apoptosis-related markers increased distinctly, accompanied by mitochondrial dynamic imbalance energy metabolism disorders mouse cells. Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, acridine orange/ethidium bromide staining Hoechst 33258 signaled number apoptotic after exposure PFOS. Noteworthy, simultaneous treatment alleviated series damages PFOS-mediated stress. Our results demonstrated alleviate dynamics disorder causing cardiomyocyte apoptosis improving capacity, suggesting may represent novel cardioprotective strategy against cardiotoxicity. findings facilitate understanding cardiotoxic effects important role protecting health.

Язык: Английский

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Selenium alleviates lead-induced CIK cells pyroptosis and inflammation through IRAK1/TAK1/IKK pathway

Fish & Shellfish Immunology, Год журнала: 2023, Номер 142, С. 109101 - 109101

Опубликована: Сен. 26, 2023

Язык: Английский

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Biochemical, Genotoxic and Histological Implications of Polypropylene Microplastics on Freshwater Fish Oreochromis mossambicus: An Aquatic Eco-Toxicological Assessment

Toxics, Год журнала: 2023, Номер 11(3), С. 282 - 282

Опубликована: Март 19, 2023

In recent years, polypropylene microplastic has persisted in freshwater ecosystems and biota, forming ever-growing threats. This research aimed to prepare microplastics evaluate their toxicity the filter feeder Oreochromis mossambicus. this research, fish were given a dietary supplement of at 100, 500, 1000 mg/kg for acute (96 h) sub-acute (14 days) durations assess toxic effects on liver tissues. FTIR results revealed presence digestion matter. The ingestion O. mossambicus led fluctuations homeostasis, an upsurge reactive oxygen species (ROS) levels, alteration antioxidant parameters, including superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx); promotion oxidation lipid molecules; denaturation neurotransmitter enzyme acetylcholinesterase (AChE). Our data indicated that sustained exposure produced more severe threat than h). addition, higher apoptosis, DNA damage (genotoxicity), histological changes found tissues microplastics-treated groups. constant is detrimental environments leads ecological

Язык: Английский

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ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency

Environmental Pollution, Год журнала: 2023, Номер 324, С. 121392 - 121392

Опубликована: Март 9, 2023

Язык: Английский

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