A world of wastewater-based epidemiology

Nature Water, Год журнала: 2023, Номер 1(5), С. 408 - 415

Опубликована: Май 22, 2023

Язык: Английский

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Wastewater surveillance for viral pathogens: A tool for public health

Heliyon, Год журнала: 2024, Номер 10(13), С. e33873 - e33873

Опубликована: Июнь 29, 2024

A focus on water quality has intensified globally, considering its critical role in sustaining life and ecosystems. Wastewater, reflecting societal development, profoundly impacts public health. Wastewater-based epidemiology (WBE) emerged as a surveillance tool for detecting outbreaks early, monitoring infectious disease trends, providing real-time insights, particularly vulnerable communities. WBE aids tracking pathogens, including viruses, sewage, offering comprehensive understanding of community health lifestyle habits. With the rise global COVID-19 cases, gained prominence, aiding SARS-CoV-2 levels worldwide. Despite advancements treatment, poorly treated wastewater discharge remains threat, amplifying spread water-, sanitation-, hygiene (WaSH)-related diseases. WBE, serving complementary surveillance, is pivotal community-level viral infections. However, there untapped potential to expand surveillance. This review emphasizes importance link between health, highlighting need further integration into management.

Язык: Английский

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Combating antibiotic resistance using wastewater surveillance: Significance, applications, challenges, and future directions

The Science of The Total Environment, Год журнала: 2023, Номер 908, С. 168056 - 168056

Опубликована: Окт. 31, 2023

Язык: Английский

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Making waves: Establishing a modeling framework to evaluate novel targets for wastewater-based surveillance

Water Research, Год журнала: 2023, Номер 245, С. 120573 - 120573

Опубликована: Сен. 2, 2023

Язык: Английский

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Wastewater early warning system for SARS-CoV-2 outbreaks and variants in a Coruña, Spain

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(32), С. 79315 - 79334

Опубликована: Июнь 7, 2023

Abstract Wastewater-based epidemiology has been widely used as a cost-effective method for tracking the COVID-19 pandemic at community level. Here we describe COVIDBENS, wastewater surveillance program running from June 2020 to March 2022 in treatment plant of Bens A Coruña (Spain). The main goal this work was provide an effective early warning tool based help decision-making both social and public health levels. RT-qPCR procedures Illumina sequencing were weekly monitor viral load detect SARS-CoV-2 mutations wastewater, respectively. In addition, own statistical models applied estimate real number infected people frequency each emerging variant circulating community, which considerable improved strategy. Our analysis detected 6 waves with concentrations between 10 3 RNA copies/L. system able anticipate outbreaks during 8–36 days advance respect clinical reports and, emergence new variants such Alpha (B.1.1.7), Delta (B.1.617.2), Omicron (B.1.1.529 BA.2) 42, 30, 27 days, respectively, before did. Data generated here helped local authorities managers give faster more efficient response situation, also allowed important industrial companies adapt their production situation. wastewater-based developed our metropolitan area (Spain) served powerful combining monitoring over time.

Язык: Английский

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Temporal, spatial, and methodological considerations in evaluating the viability of measles wastewater surveillance

The Science of The Total Environment, Год журнала: 2024, Номер 959, С. 178141 - 178141

Опубликована: Дек. 21, 2024

Язык: Английский

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Wastewater-based epidemiology of SARS-CoV-2 and the development of early warning system: challenges and lessons learned after two years of weekly surveillance in the Brazilian Federal District

Опубликована: Фев. 1, 2025

Язык: Английский

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Advancing Health Equity in Wastewater-Based Epidemiology: A Global Critical Review and Conceptual Framework

SSM - Population Health, Год журнала: 2025, Номер unknown, С. 101786 - 101786

Опубликована: Март 1, 2025

Population health data from wastewater-based epidemiology (WBE) are being used at unprecedented scales worldwide, yet there is limited focus on how to advance equity in the field. Addressing this gap, we conducted a critical review of published literature PubMed, targeting studies intersection WBE and equity. Of 145 articles assessed full-text screening, identified 68 with considerations. These spanned various spatial biochemical targets, addressing domains such as study design methodologies, ethical social considerations, feasibility implementation monitoring. We summarize synthesize equity-oriented considerations across domains. further propose five key research practice, integrate these into conceptual framework illustrate they apply major steps process conducting WBE. include global inequities access, need prevent potential harms stigma via misuse (inappropriate reporting use for criminal surveillance), importance regulation community engagement, particularly amidst growing privatization WBE, especially United States.

Язык: Английский

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Near-source wastewater surveillance of SARS-CoV-2, norovirus, influenza virus and RSV across five different sites in the UK

PLOS Global Public Health, Год журнала: 2025, Номер 5(4), С. e0004397 - e0004397

Опубликована: Апрель 9, 2025

By tracking infectious diseases through sewage, municipal-scale wastewater surveillance has provided early warnings of future COVID-19 hospitalisations, identified biases in diagnostic testing, and is rapidly expanding to a broader array pathogens. Despite applications the targeted delivery local interventions, near-source received less attention we know little about time series dynamics contrasting To address this, conducted at five sites for SARS-CoV-2 two norovirus GI, GII, influenza A virus, B human respiratory syncytial virus (RSV RSV B). Sites were selected functions: an office, charity centre, museum, university, care home. The key findings are (1) detections linked events (staff sickness, enhanced cleaning, changing populations); (2) decreased order GII > GI ≈ B; (3) correlation between data national increases as function catchment size viral prevalence (examples include BA.4/BA.5 variant peak museum winter season); (4) strong weekday periodicity detections, with against case numbers increasing when modelling variable lag times faecal shedding onset clinical diagnosis (R 2 = 0.45 0.84-0.86); (5) log-linear relationship frequency detection log(catchment size⋅viral prevalence) 0.6914-0.9066). Finally, propose use cases. Firstly, rare or high-risk pathogens, sentinel systems provide warning outbreaks, achieving high community coverage without behaviour change low cost versus testing. Secondly, endemic reveals long-term patterns trends, effectiveness policies, vulnerabilities.

Язык: Английский

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Advances in Wastewater-Based Epidemiology for Pandemic Surveillance: Methodological Frameworks and Future Perspectives

Microorganisms, Год журнала: 2025, Номер 13(5), С. 1169 - 1169

Опубликована: Май 21, 2025

Wastewater-based epidemiology (WBE) has emerged as a transformative approach for community-level health monitoring, particularly during the COVID-19 pandemic. This review critically examines methodological framework of WBE systems through following three core components: (1) sampling strategies that address spatial–temporal variability in wastewater systems, (2) comparative performance different platforms pathogen detection, and (3) predictive modeling integrating machine learning approaches. We systematically analyze how these components collectively overcome limitations conventional surveillance methods early outbreak asymptomatic case identification, population-level trend monitoring. While highlighting technical breakthroughs viral concentration variant tracking sequencing, also identifies persistent challenges, including data standardization, cost-effectiveness concerns resource-limited settings, ethical considerations public surveillance. Drawing insights from global implementation cases, we propose recommendations optimizing each operational phase discuss emerging applications beyond pandemic response. highlights an indispensable tool modern health, whose refinements cross-disciplinary integration are critical transforming reactive containment to proactive population management.

Язык: Английский

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