International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11462 - 11462
Опубликована: Окт. 25, 2024
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
death
globally,
with
atherosclerosis
(AS)
playing
central
role
in
its
pathogenesis
as
chronic
inflammatory
condition.
Copper,
an
essential
trace
element
the
human
body,
participates
various
biological
processes
and
plays
significant
cardiovascular
system.
Maintaining
normal
copper
homeostasis
crucial
for
health,
dysregulation
balance
closely
associated
development
CVD.
When
disrupted,
it
can
induce
cell
death,
which
has
been
proposed
to
be
novel
form
"cuproptosis",
distinct
from
traditional
programmed
death.
This
new
linked
occurrence
progression
AS.
article
elaborately
describes
physiological
mechanisms
explores
interactions
signaling
pathways
related
Additionally,
we
focus
on
process
mechanism
induced
by
imbalances
summarize
relationship
between
homeostasis-related
genes
We
also
emphasize
potential
therapeutic
approaches,
such
regulators
nanotechnology
interventions,
adjust
levels
providing
ideas
strategies
prevention
treatment
Drug and Chemical Toxicology,
Год журнала:
2023,
Номер
unknown, С. 1 - 12
Опубликована: Дек. 26, 2023
Drug-induced
liver
injury
(DILI)
is
characterized
by
hepatocyte
injury,
cholestasis
and
mixed
injury.
The
transplantation
required
for
serious
clinical
outcomes
such
as
acute
failure.
Current
studies
have
found
that
many
mechanisms
were
involved
in
DILI,
mitochondrial
oxidative
stress,
apoptosis,
necroptosis,
autophagy,
ferroptosis,
etc.
Ferroptosis
occurs
when
hepatocytes
die
from
iron-dependent
lipid
peroxidation
plays
a
key
role
DILI.
After
entry
into
the
liver,
where
some
drugs
or
chemicals
are
metabolized,
they
convert
hepatotoxic
substances,
consume
reduced
glutathione
(GSH),
decrease
reductive
capacity
of
GSH-dependent
GPX4,
leading
to
redox
imbalance
increase
reactive
oxygen
species
(ROS)
level,
undermining
hepatocytes;
facilitated
autophagy
ferritin,
orchestrating
increased
ion
level
ferroptosis.
purpose
this
review
summarize
ferroptosis
chemical-
drug-induced
(chemical/DILI)
how
natural
products
inhibit
prevent
chemical/DILI.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11462 - 11462
Опубликована: Окт. 25, 2024
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
death
globally,
with
atherosclerosis
(AS)
playing
central
role
in
its
pathogenesis
as
chronic
inflammatory
condition.
Copper,
an
essential
trace
element
the
human
body,
participates
various
biological
processes
and
plays
significant
cardiovascular
system.
Maintaining
normal
copper
homeostasis
crucial
for
health,
dysregulation
balance
closely
associated
development
CVD.
When
disrupted,
it
can
induce
cell
death,
which
has
been
proposed
to
be
novel
form
"cuproptosis",
distinct
from
traditional
programmed
death.
This
new
linked
occurrence
progression
AS.
article
elaborately
describes
physiological
mechanisms
explores
interactions
signaling
pathways
related
Additionally,
we
focus
on
process
mechanism
induced
by
imbalances
summarize
relationship
between
homeostasis-related
genes
We
also
emphasize
potential
therapeutic
approaches,
such
regulators
nanotechnology
interventions,
adjust
levels
providing
ideas
strategies
prevention
treatment
