Environment International,
Год журнала:
2024,
Номер
191, С. 108987 - 108987
Опубликована: Авг. 30, 2024
Triclocarban
(TCC)
is
an
antimicrobial
ingredient
that
commonly
incorporated
in
many
household
and
personal
care
products,
raising
public
concerns
about
its
potential
health
risks.
Previous
research
has
showed
TCC
could
cross
the
blood-brain
barrier,
but
to
date
our
understanding
of
neurotoxicity
at
human-relevant
concentrations
remains
lacking.
In
this
study,
we
observed
anxiety-like
behaviors
mice
with
continuous
percutaneous
exposure
TCC.
Subsequently,
combined
lipidomic,
proteomic,
metabolic
landscapes
investigate
underlying
mechanisms
TCC-related
neurotoxicity.
The
results
dysregulated
proteins
involved
endocytosis
neurodegenerative
disorders
mouse
cerebrum.
Brain
energy
homeostasis
was
also
altered,
as
evidenced
by
perturbation
pyruvate
metabolism,
TCA
cycle,
oxidative
phosphorylation,
which
turn
caused
mitochondrial
dysfunction.
Meanwhile,
changing
trends
sphingolipid
signaling
pathway
overproduction
reactive
oxygen
species
(mROS)
enhance
neural
apoptosis.
vitro
approach
further
demonstrated
promoted
apoptosis,
accompanied
mROS
alteration
membrane
N2A
cells.
Together,
endocytosis,
mROS-related
dysfunction
cell
apoptosis
are
considered
be
crucial
factors
for
TCC-induced
neurotoxicity,
may
contribute
occurrence
development
disorders.
Our
findings
provide
novel
perspectives
TCC-triggered
Antibiotics,
Год журнала:
2023,
Номер
12(4), С. 724 - 724
Опубликована: Апрель 7, 2023
Antimicrobial
resistance
(AMR)
is
one
of
the
world's
industrialized
nations'
biggest
issues.
It
has
a
significant
influence
on
ecosystem
and
negatively
affects
human
health.
The
overuse
antibiotics
in
healthcare
agri-food
industries
historically
been
defined
as
leading
factor,
although
use
antimicrobial-containing
personal
care
products
plays
role
spread
AMR.
Lotions,
creams,
shampoos,
soaps,
shower
gels,
toothpaste,
fragrances,
other
items
are
used
for
everyday
grooming
hygiene.
However,
addition
to
primary
ingredients,
additives
included
help
preserve
product
by
lowering
its
microbial
load
provide
disinfection
properties.
These
same
substances
released
into
environment,
escaping
traditional
wastewater
treatment
methods
remaining
ecosystems
where
they
contact
communities
promote
resistance.
study
antimicrobial
compounds,
which
often
solely
researched
from
toxicological
point
view,
must
be
resumed
considering
recent
discoveries,
highlight
their
contribution
Parabens,
triclocarban,
triclosan
among
most
worrying
chemicals.
To
investigate
this
issue,
more
effective
models
chosen.
Among
them,
zebrafish
crucial
system
because
it
allows
assessment
both
risks
associated
with
exposure
these
well
environmental
monitoring.
Furthermore,
artificial
intelligence-based
computer
systems
useful
simplifying
handling
antibiotic
data
speeding
up
drug
discovery
processes.
Environment & Health,
Год журнала:
2024,
Номер
2(7), С. 424 - 440
Опубликована: Май 4, 2024
Triclosan
(TCS)
has
garnered
significant
attention
due
to
its
widespread
use
and
associated
endocrine-disrupting
effects.
However,
impact
on
the
neuroendocrine
system
underlying
mechanisms
remain
poorly
understood.
Here,
we
established
correlations
between
TCS
exposure
serum
sex
hormone
levels
in
participants
of
National
Health
Nutrition
Examination
Survey
(NHANES).
Additionally,
investigated
TCS's
influence
using
adult
zebrafish
exposed
environmentally
relevant
concentrations
(0.361–48.2
μg/L)
for
21
days.
Assessment
reproductive
neurotoxicity
included
histopathological
examination
behavioral
tests.
Transcriptomics,
proteomics
analyses,
biochemical
detection
were
employed
elucidate
TCS-induced
disruption.
Significant
found
estradiol,
testosterone,
hormone-binding
globulin
NHANES
participants.
In
addition,
inhibited
ovary
development
spermatogenesis
zebrafish.
Transcriptomics
analysis
revealed
gender-specific
key
signaling
metabolism-related
pathways
implicated
toxicity.
Moreover,
induced
nervous
impairment,
as
evidenced
by
histological
changes
altered
motor
behavior,
possibly
with
oxidative
damage.
Correlation
further
highlighted
potential
connection
endocrine
disruption
impairment
following
exposure.
Overall,
this
study
provided
evidence
supporting
offered
insights
into
mechanisms.
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
14(11), С. 101024 - 101024
Опубликована: Июнь 26, 2024
Triclocarban
(TCC)
is
a
common
antimicrobial
agent
that
has
been
widely
used
in
medical
care.
Given
the
close
association
between
TCC
treatment
and
metabolic
disorders,
we
assessed
whether
long-term
to
at
human-relevant
concentration
could
induce
nephrotoxicity
by
disrupting
levels
mouse
model.
Matrix-assisted
laser
desorption/ionization
mass
spectrometry
imaging
(MALDI-MSI)
was
applied
investigate
alterations
spatial
distributions
abundances
of
TCC,
endogenous
exogenous
metabolites
kidney
after
treatment.
The
results
showed
induced
changes
organ
weight,
coefficient
histopathology
kidney.
MSI
data
reveled
accumulated
all
regions
kidney,
while
its
five
mainly
distributed
cortex
regions.
79
biomolecules
associated
with
pathways
leukotriene
E4
metabolism,
biosythesis
degradation
glycerophospholipids
glycerolipids,
ceramide-to-sphingomyelin
signaling
were
significantly
altered
These
distinctive
displayed
favorable
correlation
pathological
damage.
This
work
offers
new
insights
into
related
mechanisms
TCC-induced
nephrotocicity
exhibits
potential
MALDI-MSI-based
metabolomics
as
promising
approach
for
risk
assessment
agents
Environment International,
Год журнала:
2024,
Номер
190, С. 108927 - 108927
Опубликована: Авг. 1, 2024
In
the
context
of
pandemic
viruses
and
pathogenic
bacteria,
triclosan
(TCS),
as
a
typical
antibacterial
agent,
is
widely
used
around
world.
However,
health
risks
from
TCS
increase
with
exposure,
it
widespread
in
environmental
human
samples.
Notably,
transformation
metabolism
could
induce
potentially
undesirable
to
humans,
rather
than
simple
decontamination
or
detoxification.
This
review
summarizes
exposure
covering
2004
2023.
Particularly,
impacts
metabolic
are
emphasized.
Environmental
transformations
aimed
at
recognized
form
carcinogenic
products
such
dioxins,
ultraviolet
light
excessive
active
chlorine
can
promote
formation
these
dioxin
congeners,
threatening
health.
Although
be
rapidly
metabolized
for
detoxification,
processes
lipophilic
ether
analogs
via
cytochrome
P450
catalysis,
causing
possible
adverse
cross-talk
reactions
disorders.
Accordingly,
may
more
harmful
metabolism.
particular,
stimulate
transmission
antibiotic
resistance
even
trace
levels,
public
Considering
accruing
epidemiological
toxicological
studies
indicating
multiple
outcomes
TCS,
we
call
on
toxicologists
pay
attention
toxicity
evolution
during
