Environment International,
Год журнала:
2024,
Номер
191, С. 108987 - 108987
Опубликована: Авг. 30, 2024
Triclocarban
(TCC)
is
an
antimicrobial
ingredient
that
commonly
incorporated
in
many
household
and
personal
care
products,
raising
public
concerns
about
its
potential
health
risks.
Previous
research
has
showed
TCC
could
cross
the
blood-brain
barrier,
but
to
date
our
understanding
of
neurotoxicity
at
human-relevant
concentrations
remains
lacking.
In
this
study,
we
observed
anxiety-like
behaviors
mice
with
continuous
percutaneous
exposure
TCC.
Subsequently,
combined
lipidomic,
proteomic,
metabolic
landscapes
investigate
underlying
mechanisms
TCC-related
neurotoxicity.
The
results
dysregulated
proteins
involved
endocytosis
neurodegenerative
disorders
mouse
cerebrum.
Brain
energy
homeostasis
was
also
altered,
as
evidenced
by
perturbation
pyruvate
metabolism,
TCA
cycle,
oxidative
phosphorylation,
which
turn
caused
mitochondrial
dysfunction.
Meanwhile,
changing
trends
sphingolipid
signaling
pathway
overproduction
reactive
oxygen
species
(mROS)
enhance
neural
apoptosis.
vitro
approach
further
demonstrated
promoted
apoptosis,
accompanied
mROS
alteration
membrane
N2A
cells.
Together,
endocytosis,
mROS-related
dysfunction
cell
apoptosis
are
considered
be
crucial
factors
for
TCC-induced
neurotoxicity,
may
contribute
occurrence
development
disorders.
Our
findings
provide
novel
perspectives
TCC-triggered
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
14(11), С. 101024 - 101024
Опубликована: Июнь 26, 2024
Triclocarban
(TCC)
is
a
common
antimicrobial
agent
that
has
been
widely
used
in
medical
care.
Given
the
close
association
between
TCC
treatment
and
metabolic
disorders,
we
assessed
whether
long-term
to
at
human-relevant
concentration
could
induce
nephrotoxicity
by
disrupting
levels
mouse
model.
Matrix-assisted
laser
desorption/ionization
mass
spectrometry
imaging
(MALDI-MSI)
was
applied
investigate
alterations
spatial
distributions
abundances
of
TCC,
endogenous
exogenous
metabolites
kidney
after
treatment.
The
results
showed
induced
changes
organ
weight,
coefficient
histopathology
kidney.
MSI
data
reveled
accumulated
all
regions
kidney,
while
its
five
mainly
distributed
cortex
regions.
79
biomolecules
associated
with
pathways
leukotriene
E4
metabolism,
biosythesis
degradation
glycerophospholipids
glycerolipids,
ceramide-to-sphingomyelin
signaling
were
significantly
altered
These
distinctive
displayed
favorable
correlation
pathological
damage.
This
work
offers
new
insights
into
related
mechanisms
TCC-induced
nephrotocicity
exhibits
potential
MALDI-MSI-based
metabolomics
as
promising
approach
for
risk
assessment
agents
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(31), С. 13687 - 13696
Опубликована: Июль 27, 2024
Bisphenols,
parabens,
and
triclosan
(TCS)
are
common
endocrine
disrupters
used
in
various
consumer
products.
These
chemicals
have
been
shown
to
cross
the
placental
barrier
affect
intrauterine
development
of
fetuses.
In
this
study,
we
quantified
serum
levels
six
bisphenols,
five
TCS
483
pregnant
women
from
southern
China.
Quantile-based
g-computation
showed
that
combined
exposure
was
significantly
(
