Integrated multi-omics approaches reveal the neurotoxicity of triclocarban in mouse brain DOI Creative Commons
Qian Song,

Chengchen Hu,

Xueying Zhang

и другие.

Environment International, Год журнала: 2024, Номер 191, С. 108987 - 108987

Опубликована: Авг. 30, 2024

Triclocarban (TCC) is an antimicrobial ingredient that commonly incorporated in many household and personal care products, raising public concerns about its potential health risks. Previous research has showed TCC could cross the blood-brain barrier, but to date our understanding of neurotoxicity at human-relevant concentrations remains lacking. In this study, we observed anxiety-like behaviors mice with continuous percutaneous exposure TCC. Subsequently, combined lipidomic, proteomic, metabolic landscapes investigate underlying mechanisms TCC-related neurotoxicity. The results dysregulated proteins involved endocytosis neurodegenerative disorders mouse cerebrum. Brain energy homeostasis was also altered, as evidenced by perturbation pyruvate metabolism, TCA cycle, oxidative phosphorylation, which turn caused mitochondrial dysfunction. Meanwhile, changing trends sphingolipid signaling pathway overproduction reactive oxygen species (mROS) enhance neural apoptosis. vitro approach further demonstrated promoted apoptosis, accompanied mROS alteration membrane N2A cells. Together, endocytosis, mROS-related dysfunction cell apoptosis are considered be crucial factors for TCC-induced neurotoxicity, may contribute occurrence development disorders. Our findings provide novel perspectives TCC-triggered

Язык: Английский

Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment DOI Creative Commons

Peisi Xie,

Jing Chen, Yongjun Xia

и другие.

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(11), С. 101024 - 101024

Опубликована: Июнь 26, 2024

Triclocarban (TCC) is a common antimicrobial agent that has been widely used in medical care. Given the close association between TCC treatment and metabolic disorders, we assessed whether long-term to at human-relevant concentration could induce nephrotoxicity by disrupting levels mouse model. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was applied investigate alterations spatial distributions abundances of TCC, endogenous exogenous metabolites kidney after treatment. The results showed induced changes organ weight, coefficient histopathology kidney. MSI data reveled accumulated all regions kidney, while its five mainly distributed cortex regions. 79 biomolecules associated with pathways leukotriene E4 metabolism, biosythesis degradation glycerophospholipids glycerolipids, ceramide-to-sphingomyelin signaling were significantly altered These distinctive displayed favorable correlation pathological damage. This work offers new insights into related mechanisms TCC-induced nephrotocicity exhibits potential MALDI-MSI-based metabolomics as promising approach for risk assessment agents

Язык: Английский

Процитировано

4

Associations of pharmaceutical and personal care product chemical exposure with thyroid nodules and thyroid homeostasis DOI
Yawen Zheng, Lei Zhang, Qian Xiang

и другие.

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Dose-dependent toxic effects of triclosan on Rana omeimontis larvae: insights into potential implications for neurodegenerative diseases DOI
Guiying Chen,

Xuemei Xia,

Jiahui Xie

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137187 - 137187

Опубликована: Янв. 10, 2025

Язык: Английский

Процитировано

0

Association between exposure to airborne endocrine disrupting chemicals and asthma in children or adolescents: A systematic review and meta-analysis DOI Creative Commons
Georges Hatem, Aurélio Faria, Mariana Pinto

и другие.

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125830 - 125830

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

The effects of Triclosan (TCS) on the survival, serum biomarkers, antioxidant defense, and apoptosis of mud crab (Scylla paramamosain) DOI
Yue Wang, Tingting Hou, Xuefeng Song

и другие.

Aquaculture Reports, Год журнала: 2025, Номер 41, С. 102719 - 102719

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

The intestinal toxicity mechanisms of Triclosan and Triclocarban and their possible clinical nutritional intervention mechanisms DOI
Xinyu Fang, Jinfeng Zhao, Simin Wu

и другие.

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126396 - 126396

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Exposure of individuals aged 18–44 years to personal care products in Beijing, China: Exposure profiles, possible influencing factors, and risk assessment DOI
Xu Zhang,

Linxue Han,

Qi Sun

и другие.

Journal of Environmental Sciences, Год журнала: 2024, Номер 148, С. 691 - 701

Опубликована: Фев. 10, 2024

Язык: Английский

Процитировано

3

Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways DOI

Ting-Ting He,

Xin Li,

Jiezhi Ma

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 931, С. 172782 - 172782

Опубликована: Апрель 26, 2024

Язык: Английский

Процитировано

3

Neurotoxic effects of triclosan in adolescent mice: Pyruvate kinase M2 dimer regulated signal transducer and activator of transcription 3 phosphorylation mediated microglia activation and neuroinflammation DOI
Ziyun Wei, Xiao Ni,

He Cui

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173739 - 173739

Опубликована: Июнь 4, 2024

Язык: Английский

Процитировано

3

Sex-Specific and Trimester-Specific Associations of Prenatal Exposure to Bisphenols, Parabens, and Triclosan with Neonatal Birth Size and Gestational Age DOI

Jinfeng Fu,

Yao Yao, Zhihong Huang

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(31), С. 13687 - 13696

Опубликована: Июль 27, 2024

Bisphenols, parabens, and triclosan (TCS) are common endocrine disrupters used in various consumer products. These chemicals have been shown to cross the placental barrier affect intrauterine development of fetuses. In this study, we quantified serum levels six bisphenols, five TCS 483 pregnant women from southern China. Quantile-based g-computation showed that combined exposure was significantly (

Язык: Английский

Процитировано

3