Sex Specificity in the Mixed Effects of Blood Heavy Metals and Cognitive Function on Elderly: Evidence from NHANES

Nutrients, Год журнала: 2023, Номер 15(13), С. 2874 - 2874

Опубликована: Июнь 25, 2023

The way that males and females react to environmental exposures negative impacts on their neurological systems is often different. Although previous research has examined the cognitively impairing effects of solitary metal exposures, relationship between mixtures cognitive function, particularly when considering an individual's sex, remains elusive. This study aimed investigate sex differences in association multiple combinations function older Americans. employed 2011-2014 NHANES survey elderly five mixed metals four tests (the animal fluency test (AFT), digit symbol substitution (DSST), instant recall (IRT), delayed (DRT)) were investigated with generalized linear regression model (GLM), Bayesian kernel machine (BKMR), weighted quantile sum (WQS), g-computation (Qgcomp). A total 1833 people, including 883 950 females, enrolled this cross-sectional study. We discovered blood lead cadmium negatively associated performance, while selenium demonstrated a positive people. heavy might be somewhat reduced or even reversed via selenium. IRT, AFT, DSST are three where men had more dramatic results. There was sex-specific connection ratios among Americans, as evidenced by significant performance (either positively negatively). These results emphasize ambient exposure employing methods.

Язык: Английский

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Phthalate exposure and markers of biological aging: The mediating role of inflammation and moderating role of dietary nutrient intake

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 281, С. 116649 - 116649

Опубликована: Июль 1, 2024

Язык: Английский

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Removal of low concentration of perchlorate from natural water by quaternized chitosan sphere (CGQS): Efficiency and mechanism research

Journal of Hazardous Materials, Год журнала: 2024, Номер 466, С. 133595 - 133595

Опубликована: Янв. 23, 2024

Язык: Английский

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Association of volatile organic compound exposure with metabolic syndrome and its components: a nationwide cross-sectional study

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Март 2, 2024

Abstract Background Metabolic syndrome (MetS) is a health issue consisting of multiple metabolic abnormalities. The impact exposure to volatile organic compounds (VOCs) on MetS and its components remains uncertain. This study aimed assess the associations individual urinary metabolites VOC (mVOCs) mVOC mixtures with among general adult population in United States. Methods A total 5345 participants eligible data were filtered from 2011–2020 cycles National Health Nutrition Examination Survey. Multivariate logistic regression models applied mVOCs components. least absolute shrinkage selection operator (LASSO) constructed identify more relevant mVOCs. weight quantile sum model was further explore links between co-exposure Results results indicated positive MetS, including CEMA, DHBMA, HMPMA. CEMA found be positively correlated all MetS. HMPMA associated elevated triglyceride (TG), reduced high-density lipoprotein, fasting blood glucose (FBG) impairment; 3HPMA an risk high TG FBG DHBMA had pressure. LASSO-selected increased TG, pressure, impairment. Conclusion Positive certain observed by utilizing statistical large-scale national data. These findings may serve as theoretical basis for future experimental mechanistic studies have important implications public health.

Язык: Английский

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Vitamin D Deficiency Exacerbates Poor Sleep Outcomes with Endocrine-Disrupting Chemicals Exposure: A Large American Population Study

Nutrients, Год журнала: 2024, Номер 16(9), С. 1291 - 1291

Опубликована: Апрель 26, 2024

Phthalates and bisphenol A are recognized as the predominant endocrine-disrupting substances (EDCs) in environment, but their impact on sleep health remains unclear. Vitamin D has often been reported to play a role may be affected by compounds. The study utilized data from 5476 individuals NHANES project investigate correlation between combined exposure environmental EDCs duration through modeling various exposures. Furthermore, it emphasizes importance of vitamin present scenario. Preliminary analyses suggested that D-deficient generally slept shorter than with normal (p < 0.05). Exposure Mono-ethyl phthalate (MEP), triclosan (TRS), Mono-benzyl (MZP), either alone or combination, was associated reduced greater risk deficiency. Individuals low levels exposed TRS experienced those MZP were identified crucial factors patient outcomes when evaluating mixed exposures results provide new supporting link insufficient length. Additionally, they imply shortage worsen problems induced EDCs.

Язык: Английский

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Impact of Polyfluoroalkyl Chemicals and Volatile Organic Compounds Exposure on Lung Function of American Adults

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125152 - 125152

Опубликована: Окт. 1, 2024

Язык: Английский

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Systemic immune-inflammation mediates the association between Klotho protein and metabolic syndrome: findings from a large-scale population-based study

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 5, 2024

This study utilized large-scale population data from the National Health and Nutrition Examination Survey (NHANES) to elucidate relationship between Klotho protein metabolic syndrome along with its components. We further investigated possible mediating effect of inflammation on these relationships. Our objective was identify biomarkers for risk stratification potential therapeutic targets syndrome. enrolled 13,119 participants aged 40–79 years, spanning five NHANES cycles 2007 2016, complete information protein. The definition followed criteria Cholesterol Education Program-Adult Treatment Panel III. Survey-weighted logistic regression subgroup analysis were used explore associations serum levels syndrome, Mediation performed investigate effects inflammation-related markers, including white blood cells, neutrophils, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII) monocyte-to-HDL (MHR), aim elucidating how influences onset progression had an average age 56.06 years (95% CI: 55.76–56.37), a concentration 798.10 pg/ml 656.50–980.50) 43.77% prevalence (n = 5742). In crude model, negatively correlated components, central obesity, hypertension, hypertriglyceridemia. After adjusting all confounding factors, demonstrated be associated only (OR: 0.82, 95% 0.70–0.97), hypertension 0.83, 0.70–0.98), hypertriglyceridemia 0.78, 0.67–0.91). Subgroup interaction analyses revealed significant interactions age, sex, race/ethnicity, body mass index, Klotho. Additionally, mediation that leukocytes, neutrophils monocytes accounted 34.78%, 31.91% 7.13%, respectively, being partly mediated by immune inflammation. findings this research may valuable biomarker target

Язык: Английский

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Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 287, С. 117269 - 117269

Опубликована: Ноя. 1, 2024

Previous studies found that urinary phthalates (PAEs) metabolites may be associated with increased serum uric acid concentration and hyperuricemia risk. However, no population-based study has investigated the underlying biological mechanisms.

Язык: Английский

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Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 14, 2025

Accumulating research highlights that exposure to serum brominated flame retardants (BFRs) may elevate health risks. The effects of BFRs, both alone and in combination, on obstructive sleep apnea syndrome (OSAS) have not been thoroughly studied. Our main goal was examine the association between individual mixtures BFRs OSAS risk. Data from National Health Nutrition Examination Survey (NHANES) were employed, including 1,341 participants. We included participants with full details OSAS, covariates, 7 types (PBDE28, PBDE47, PBDE99, PBDE100, PBDE153, PBB153, PBDE209). To investigate risk exposure, multivariate logistic regression, weighted quantile sum (WQS) g-computation (QGC), Bayesian kernel machine regression (BKMR) models, restricted cubic splines (RCS) implemented. Serum PBDE28, showed positive correlations toxic effect co-exposure consistently demonstrated through results WQS QGC BKMR models. PBB153 determined be most BFRs. Additionally, RCS model also verified strong non-linear relationship existed PBB153. Findings study prove exerts a deleterious Future large-scale prospective investigations experimental studies are desirable confirm these findings.

Язык: Английский

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Identification of the associations between co-exposure to organophosphate flame retardants and thyroid dysfunction and exposure risk factors in residents of Shanghai, China

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125911 - 125911

Опубликована: Фев. 1, 2025

Язык: Английский

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