Reaction Chemistry & Engineering,
Год журнала:
2024,
Номер
9(4), С. 753 - 776
Опубликована: Янв. 1, 2024
This
review
article
provides
a
detailed
overview
of
the
synthesis
techniques
biomass-based
graphene
aerogels
and
highlights
influence
fabrication
parameters
on
performance
resulting
for
wastewater
treatment
applications.
Abstract
Background
Gestational
exposure
to
non-persistent
endocrine-disrupting
chemicals
(EDCs)
may
be
associated
with
adverse
pregnancy
outcomes.
While
many
EDCs
affect
the
endocrine
system,
their
effects
on
endocrine-related
metabolic
pathways
remain
unclear.
This
study
aims
explore
global
metabolome
changes
EDC
biomarkers
at
delivery.
Methods
included
75
pregnant
individuals
who
delivered
University
of
Cincinnati
Hospital
from
2014
2017.
We
measured
maternal
urinary
paraben/phenol
(12),
phthalate
(13),
and
replacements
(4)
samples
collected
during
delivery
visit.
Global
serum
profiles
were
analyzed
blood
(
n
=
72)
newborn
63)
cord
Fifteen
29
excluded
due
low
detection
frequency
or
potential
exposures
hospital
stay.
assessed
metabolome-wide
associations
between
14
maternal/newborn
profiles.
Additionally,
performed
enrichment
analysis
identify
alterations
in
pathways.
Results
observed
concentrations
metabolites
(mono-isobutyl
phthalate),
(mono-2-ethyl-5-carboxypentyl
terephthalate,
mono-2-ethyl-5-hydroxyhexyl
terephthalate)
phenols
(bisphenol-A,
bisphenol-S)
metabolome,
using
q-value
<
0.2
as
a
threshold.
(mono-n-butyl
phthalate,
monobenzyl
phthalate)
(2,5-dichlorophenol,
BPA)
noted.
Enrichment
analyses
revealed
(p-gamma
0.05)
amino
acid,
carbohydrate,
lipid,
glycan,
vitamin,
other
cofactor
metabolism
Conclusion
Maternal
paraben,
phenol,
replacement
biomarker
metabolome.
Environment International,
Год журнала:
2025,
Номер
196, С. 109298 - 109298
Опубликована: Янв. 29, 2025
Gestational
exposures
to
single
toxic
chemicals
have
been
associated
with
cognitive
deficits
in
children,
but
few
studies
explored
chemical
mixtures.
To
evaluate
the
associations
between
gestational
biomarker
mixtures
and
abilities
children
from
two
prospective
cohorts.
This
study
includes
617
birthing
parent-child
pairs
Health
Outcomes
Measures
of
Environment
(HOME)
Maternal-Infant
Research
on
Environmental
Chemicals
(MIREC)
Studies.
We
measured
29
biomarkers
(metals,
persistent
organic
pollutants,
perfluoroalkyl
substances,
organophosphate
esters,
phenols,
phthalates,
pesticides,
parabens)
pregnant
individuals
during
early
pregnancy
their
children's
at
ages
3
5
years
using
Wechsler
Intelligence
Scales.
assessed
linear
quantile
g-computation
non-linear
Bayesian
Kernel
Machine
Regression
(BKMR)
methods,
adjusted
for
covariates.
Using
g-computation,
we
observed
overall
null
mixture
outcomes
among
preschool-age
children.
Although
statistical
significance
was
not
attained
child
sex
as
an
effect
modifier,
our
stratified
analysis
unveiled
a
moderate
divergence
association
trends.
noted
marginal
inverse
trend
scores
[Full-Scale
Quotient
(FSIQ)
&
Performance
(PIQ)]
males.
BKMR
that
PBDE47,
PFHxS,
di-ethyl
organophosphates
commonly
contributed
towards
decline
FSIQ
Among
males,
quartile
increase
0.64-point
decrease
(95%
CI:
-2.59,
1.31)
score
1.59-point
-3.72,
0.54)
PIQ
score.
In
this
study,
weak
negative
(FSIQ/PIQ)
Further
are
needed
confirm
findings
longitudinal
school
ages.
Environmental Science and Pollution Research,
Год журнала:
2024,
Номер
31(37), С. 49682 - 49693
Опубликована: Июль 30, 2024
Abstract
This
study
investigates
the
current
situation
and
possible
health
risks
due
to
pharmaceutically
active
compounds
(PhACs)
including
analgesics,
antibiotics,
antifungals,
anti-inflammatories,
psychiatric
cardiovascular
drugs,
metabolites,
in
indoor
environments.
To
achieve
this
objective,
a
total
of
85
dust
samples
were
collected
2022
from
three
different
Spanish
environments:
homes,
classrooms,
offices.
The
analytical
method
was
validated
meeting
SANTE/2020/12830
SANTE/12682/2019
performance
criteria.
All
except
one
presented
at
least
PhAC.
Although
concentration
levels
ranged
<
LOQ
18
µg/g,
only
acetaminophen,
thiabendazole,
clotrimazole,
anhydroerythromycin
showed
quantification
frequencies
(Qf
%)
above
19%
with
median
concentrations
166
ng/g,
74
25
ng/g
14
respectively.
PhAC
distribution
between
deposited
on
floor
settled
elevated
(>
0.5
m)
surfaces
assessed
but
no
significant
differences
(p
>
0.05,
Mann–Whitney
U-test)
found.
However,
quantified
types
locations
Kruskal–Wallis
H-test).
Homes
turned
out
be
environment
higher
pharmaceutical
concentrations,
especially
acetaminophen
(678
median).
use
these
medicines
their
subsequent
removal
body
identified
as
main
sources
dust.
Relationships
occupant
habits,
building
characteristics,
and/or
medicine
consumption
studied.
Finally,
account
differences,
estimated
daily
intakes
(EDIs)
for
inhalation,
ingestion
dermal
adsorption
exposure
pathways
calculated
toddlers,
adolescents
adults
classrooms
offices
separately.
Results
proved
that
is
route
exposure,
contributing
more
than
99%
all
Moreover,
studied
groups,
occupational
(classrooms
offices)
are
much
lower
obtained
where
hazard
indexes
(HIs)
(7%—12%)
clotrimazole
(4%-7%)
worst
scenario
(P95)
highlight
need
continuous
monitoring.
