Reviews in Biological and Biomedical Sciences,
Год журнала:
2023,
Номер
5(1), С. 19 - 27
Опубликована: Дек. 29, 2023
Concerns
regarding
the
properties
and
potential
hazardous
effects
of
food
additives
are
increasing.Food
widely
used
because
they
improve
taste,
texture,
color
shelf
life
food.While
commonly
consumed
worldwide,
have
begun
to
raise
more
concerns
their
impact
on
human
health
environment.Thus,
new
extensive
but
animal-minimized
testing
strategies
needed
highlight
short-and
long-term
many
additives.Thus,
it
was
necessary
find
alternatives
for
toxicology
studies,
such
as
ex
vivo/in
vitro
testing,
embryos
larvae
that
external
fertilization
embryonic
or
larval
development.There
studies
usefulness
non-mammalian
models,
fish
larvae.Fish
preferred
in
vivo
numerous
advantages,
short-term
development,
transparent,
genes,
receptors
molecular
processes
highly
conserved
between
fish.In
this
review
article
we
aimed
tested
toxic
larvae,
toxicological
parameters
establish
toxicity
most
common
anomalies
caused
by
additives.
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 7, 2024
Parabens
are
the
most
prevalent
ingredients
in
cosmetics
and
personal
care
products
(PCPs).
They
colorless
tasteless
exhibit
good
stability
when
combined
with
other
components.
Because
of
these
unique
physicochemical
properties,
they
extensively
used
as
antimicrobial
antifungal
agents.
Their
release
into
aquatic
ecosystem
poses
potential
threats
to
organisms,
including
fish.
We
conducted
an
electronic
search
PubMed
(
http://www.ncbi.nlm.nih.gov/pubmed
)
using
term
parabens
fish
sorted
93
articles
consisting
methyl
paraben
(MTP),
ethyl
(ETP),
propyl
(PPP),
butyl
(BTP),
benzyl
(BNP)
several
species.
Furthermore,
we
confined
our
six
species
(common
carp,
Cyprinus
carpio
;
fathead
minnows,
Pimephales
promelas
Japanese
medaka,
Oryzias
latipes
rainbow
trout,
Oncorhynchus
mykiss
Nile
tilapia,
Oreochromis
niloticus
zebrafish,
Danio
rerio)
four
common
(MTP,
ETP,
PPP,
BTP)
48
for
review.
Our
indicates
that
among
all
fish,
zebrafish
was
studied
MTP
tested
Moreover,
depending
on
alkyl
chain
length
linearity,
long-chained
were
more
toxic
than
short
chains.
can
be
considered
endocrine
disruptors
(EDs),
targeting
estrogen-androgen-thyroid-steroidogenesis
(EATS)
pathways,
blocking
development
growth
gametes,
causing
intergenerational
toxicity
impact
viability
offspring/larvae.
Paraben
exposure
also
induce
behavioral
changes
nervous
system
disorders
Although
USEPA
EU
limit
use
pharmaceuticals,
their
prolonged
persistence
environment
may
pose
additional
health
risk
humans.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
268, С. 115704 - 115704
Опубликована: Ноя. 16, 2023
Studies
on
the
comparison
of
developmental
(neuro)
toxicity
parabens
are
currently
limited,
and
unharmonized
concentrations
between
phenotypic
observations
transcriptome
analysis
hamper
understanding
their
differential
molecular
mechanisms.
Thus,
testing
was
conducted
herein
using
commonly
used
methyl-
(MtP),
ethyl-
(EtP),
propyl-parabens
(PrP)
in
zebrafish
embryos.
With
a
benchmark
dose
5%,
embryonic-mortality-based
point-of-departure
(M-POD)
values
three
were
determined,
changes
locomotor
behavior
evaluated
at
0,
M-POD/50,
M-POD/10,
M-POD,
where
to
explore
underlying
neurotoxicity
mechanism.
Higher
long-chained
more
toxic
than
short-chained
parabens,
as
determined
by
M-POD
154.1,
72.6,
24.2
µM
for
MtP,
EtP,
PrP,
respectively.
Meanwhile,
exposure
EtP
resulted
hyperactivity,
whereas
no
behavioral
effect
observed
with
MtP
PrP.
Transcriptome
revealed
that
abnormal
behaviors
EtP-exposed
group
associated
distinctly
enriched
pathways
signaling,
transport,
calcium
ion
binding,
metal
binding.
In
contrast,
PrP
mainly
disrupted
membranes
transmembranes,
which
closely
linked
embryonic
development
rather
neurobehavioral
changes.
According
expressions
signature
mRNAs,
tentative
transcriptome-based
POD
each
paraben
(2.68
µM),
(3.85
(1.4
µM).
This
suggests
different
perturbations
initiated
similar
extent
outcome
differently.
Our
findings
provide
insight
into
better
mechanisms
parabens.
Reviews in Environmental Science and Bio/Technology,
Год журнала:
2024,
Номер
23(3), С. 633 - 677
Опубликована: Авг. 24, 2024
Abstract
Endocrine-disrupting
compounds
(EDCs)
are
ubiquitous
in
soil,
posing
serious
risks
to
soil
biota,
especially
earthworms,
which
have
been
found
be
affected
by
these
compounds,
despite
not
being
their
typical
target
organisms.
Earthworms
essential
for
sustaining
health
and
quality,
promoting
aeration,
organic
matter
decomposition
nutrient
cycling,
among
other
functions.
This
review
synthesizes
available
literature
evidencing
the
negative
impact
of
EDC
exposure,
through
traditional
endocrine
pathways
toxicological
mechanisms,
on
histopathological,
biochemical,
molecular
reproductive
endpoints
earthworms.
The
described,
consulted
literature,
induce
genotoxicity
alterations
include
antibiotics,
antimicrobial
additives,
flame
retardants,
fragrances,
fungicides,
herbicides,
hormones,
inorganic
ions,
insecticides,
UV
filters,
parabens,
perfluoroalkyl
substances,
pesticides,
petroleum
derivatives,
plasticizers
polychlorinated
biphenyls.
These
reach
direct
application
or
via
contaminated
amendments
water
derived
from
potentially
polluted
sources.
findings
gather
present
highlight
vulnerability
earthworms
a
broad
spectrum
chemicals
with
disrupting
capacity.
Additionally,
studies
emphasize
physiological
disruptions
caused
underscoring
critical
need
protect
biodiversity,
including
ensure
quality
ecosystem
sustainability.
Ongoing
research
has
provided
insights
into
mechanisms
responsive
EDCs
identification
putative
hormone
receptors
that
exhibit
functional
similarity
those
vertebrates.
In
conclusion,
this
emphasizes
non-hormonal
mediated
pathways,
addresses
strong
regulatory
frameworks
mitigate
detrimental
effects
invertebrates
order
safeguard
ecosystems.
Graphical
abstract
Parabens
(PBs)
are
commonly
utilized
as
preservatives
in
various
commodities.
Of
all
the
PBs,
methylparaben
(MeP)
and
butylparaben
(BuP)
usually
found
together
at
similar
levels
aqueous
environment.
Although
a
few
studies
have
demonstrated
that
PBs
neurotoxic
when
present
alone,
neurobehavioral
toxic
effects
mechanisms
of
coexisting
MeP
BuP
environmental
has
not
been
determined.
Neurobehavior
is
sensitive
indicator
for
identifying
neurotoxicity
pollutants.
Therefore,
adult
female
zebrafish
(Danio
rerio)
were
co-exposed
to
(5,
50
500
ng/L)
60
d
investigate
on
neurobehavior,
histopathology,
oxidative
stress,
mitochondrial
function,
neurotransmitters
gene
expression.
The
results
co-exposure
interfered
with
several
behaviors
(learning-memory,
anxiety,
fear,
aggressive
shoaling
behavior)
addition
known
producing
stress
disrupting
energy.
More
intriguingly,
caused
retinal
vacuolization
apoptosis
optic
tectum
zone,
impacted
phototransduction
pathway,
impaired
optesthesia,
neurotransmitter
dysregulation,
which
might
underlying
resulting
abnormalities.
This
study
confirms
pollution
multiple
by
chronic
aquatic
environments
can
result
toxicity,
indicating
prolonged
ecosystems
health
require
close
attention.
