Fish larvae: an alternative animal model for testing the toxicity of food additives DOI Open Access

Madalina Elena Ristea,

Otilia Zărnescu

Reviews in Biological and Biomedical Sciences, Год журнала: 2023, Номер 5(1), С. 19 - 27

Опубликована: Дек. 29, 2023

Concerns regarding the properties and potential hazardous effects of food additives are increasing.Food widely used because they improve taste, texture, color shelf life food.While commonly consumed worldwide, have begun to raise more concerns their impact on human health environment.Thus, new extensive but animal-minimized testing strategies needed highlight short-and long-term many additives.Thus, it was necessary find alternatives for toxicology studies, such as ex vivo/in vitro testing, embryos larvae that external fertilization embryonic or larval development.There studies usefulness non-mammalian models, fish larvae.Fish preferred in vivo numerous advantages, short-term development, transparent, genes, receptors molecular processes highly conserved between fish.In this review article we aimed tested toxic larvae, toxicological parameters establish toxicity most common anomalies caused by additives.

Язык: Английский

Molecular interactions of paraben family of pollutants with embryonic neuronal proteins of Danio rerio: A step ahead in computational toxicity towards adverse outcome pathway DOI
Prerna Mahesh Gaidhani,

Swastik Chakraborty,

Kheerthana Ramesh

и другие.

Chemosphere, Год журнала: 2024, Номер 351, С. 141155 - 141155

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

9

Effect of pH on UV/H2O2-mediated removal of single, mixed and halogenated parabens from water DOI

Yanru Huo,

Mingxue Li,

Zexiu An

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 462, С. 132818 - 132818

Опубликована: Окт. 20, 2023

Язык: Английский

Процитировано

12

Environmental pollution of paraben needs attention: A study of methylparaben and butylparaben co-exposure trigger neurobehavioral toxicity in zebrafish DOI
Jing Xiang,

B. Lv,

Yajun Shi

и другие.

Environmental Pollution, Год журнала: 2024, Номер 356, С. 124370 - 124370

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

4

Sub-chronically exposing zebrafish to environmental levels of methomyl induces dysbiosis and dysfunction of the gut microbiota DOI
Mingxiao Li, Xi Chen, Chao Song

и другие.

Environmental Research, Год журнала: 2024, Номер 261, С. 119674 - 119674

Опубликована: Июль 23, 2024

Язык: Английский

Процитировано

4

A systematic review of the toxic potential of parabens in fish DOI Creative Commons
Asok K. Dasmahapatra,

Joydeep Chatterjee,

Paul B. Tchounwou

и другие.

Frontiers in Toxicology, Год журнала: 2024, Номер 6

Опубликована: Окт. 7, 2024

Parabens are the most prevalent ingredients in cosmetics and personal care products (PCPs). They colorless tasteless exhibit good stability when combined with other components. Because of these unique physicochemical properties, they extensively used as antimicrobial antifungal agents. Their release into aquatic ecosystem poses potential threats to organisms, including fish. We conducted an electronic search PubMed ( http://www.ncbi.nlm.nih.gov/pubmed ) using term parabens fish sorted 93 articles consisting methyl paraben (MTP), ethyl (ETP), propyl (PPP), butyl (BTP), benzyl (BNP) several species. Furthermore, we confined our six species (common carp, Cyprinus carpio ; fathead minnows, Pimephales promelas Japanese medaka, Oryzias latipes rainbow trout, Oncorhynchus mykiss Nile tilapia, Oreochromis niloticus zebrafish, Danio rerio) four common (MTP, ETP, PPP, BTP) 48 for review. Our indicates that among all fish, zebrafish was studied MTP tested Moreover, depending on alkyl chain length linearity, long-chained were more toxic than short chains. can be considered endocrine disruptors (EDs), targeting estrogen-androgen-thyroid-steroidogenesis (EATS) pathways, blocking development growth gametes, causing intergenerational toxicity impact viability offspring/larvae. Paraben exposure also induce behavioral changes nervous system disorders Although USEPA EU limit use pharmaceuticals, their prolonged persistence environment may pose additional health risk humans.

Язык: Английский

Процитировано

3

Transcriptome analysis reveals differences in developmental neurotoxicity mechanism of methyl-, ethyl-, and propyl- parabens in zebrafish embryos DOI Creative Commons

Cong Minh Tran,

Jin‐Sung Ra,

Dong Young Rhyu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 268, С. 115704 - 115704

Опубликована: Ноя. 16, 2023

Studies on the comparison of developmental (neuro) toxicity parabens are currently limited, and unharmonized concentrations between phenotypic observations transcriptome analysis hamper understanding their differential molecular mechanisms. Thus, testing was conducted herein using commonly used methyl- (MtP), ethyl- (EtP), propyl-parabens (PrP) in zebrafish embryos. With a benchmark dose 5%, embryonic-mortality-based point-of-departure (M-POD) values three were determined, changes locomotor behavior evaluated at 0, M-POD/50, M-POD/10, M-POD, where to explore underlying neurotoxicity mechanism. Higher long-chained more toxic than short-chained parabens, as determined by M-POD 154.1, 72.6, 24.2 µM for MtP, EtP, PrP, respectively. Meanwhile, exposure EtP resulted hyperactivity, whereas no behavioral effect observed with MtP PrP. Transcriptome revealed that abnormal behaviors EtP-exposed group associated distinctly enriched pathways signaling, transport, calcium ion binding, metal binding. In contrast, PrP mainly disrupted membranes transmembranes, which closely linked embryonic development rather neurobehavioral changes. According expressions signature mRNAs, tentative transcriptome-based POD each paraben (2.68 µM), (3.85 (1.4 µM). This suggests different perturbations initiated similar extent outcome differently. Our findings provide insight into better mechanisms parabens.

Язык: Английский

Процитировано

6

Do endocrine disrupting compounds impact earthworms? A comprehensive evidence review DOI Creative Commons
Tiago Azevedo, Mariana Gonçalves, Rita Silva‐Reis

и другие.

Reviews in Environmental Science and Bio/Technology, Год журнала: 2024, Номер 23(3), С. 633 - 677

Опубликована: Авг. 24, 2024

Abstract Endocrine-disrupting compounds (EDCs) are ubiquitous in soil, posing serious risks to soil biota, especially earthworms, which have been found be affected by these compounds, despite not being their typical target organisms. Earthworms essential for sustaining health and quality, promoting aeration, organic matter decomposition nutrient cycling, among other functions. This review synthesizes available literature evidencing the negative impact of EDC exposure, through traditional endocrine pathways toxicological mechanisms, on histopathological, biochemical, molecular reproductive endpoints earthworms. The described, consulted literature, induce genotoxicity alterations include antibiotics, antimicrobial additives, flame retardants, fragrances, fungicides, herbicides, hormones, inorganic ions, insecticides, UV filters, parabens, perfluoroalkyl substances, pesticides, petroleum derivatives, plasticizers polychlorinated biphenyls. These reach direct application or via contaminated amendments water derived from potentially polluted sources. findings gather present highlight vulnerability earthworms a broad spectrum chemicals with disrupting capacity. Additionally, studies emphasize physiological disruptions caused underscoring critical need protect biodiversity, including ensure quality ecosystem sustainability. Ongoing research has provided insights into mechanisms responsive EDCs identification putative hormone receptors that exhibit functional similarity those vertebrates. In conclusion, this emphasizes non-hormonal mediated pathways, addresses strong regulatory frameworks mitigate detrimental effects invertebrates order safeguard ecosystems. Graphical abstract

Язык: Английский

Процитировано

2

Bioaccumulation and ecotoxicity of parabens in aquatic organisms: Current status and trends DOI
Fernando Silveira, Viviane Amaral Porto,

Bianca Leite Carnib de Sousa

и другие.

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125213 - 125213

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

2

The detrimental effects and mechanisms of orlistat in disrupting energy homeostasis and reproduction in Daphnia magna DOI

Zhihua Ni,

Xinling Tian,

Wenbo Zhao

и другие.

Aquatic Toxicology, Год журнала: 2024, Номер 279, С. 107201 - 107201

Опубликована: Дек. 7, 2024

Язык: Английский

Процитировано

1

Environmental Pollution of Paraben Needs Attention: A Study of Methylparaben and Butylparaben Co-Exposure Trigger Neurobehavioral Toxicity in Zebrafish (Danio Rerio) DOI
Jing Xiang,

Bing-Rui Lv,

Yajun Shi

и другие.

Опубликована: Янв. 1, 2024

Parabens (PBs) are commonly utilized as preservatives in various commodities. Of all the PBs, methylparaben (MeP) and butylparaben (BuP) usually found together at similar levels aqueous environment. Although a few studies have demonstrated that PBs neurotoxic when present alone, neurobehavioral toxic effects mechanisms of coexisting MeP BuP environmental has not been determined. Neurobehavior is sensitive indicator for identifying neurotoxicity pollutants. Therefore, adult female zebrafish (Danio rerio) were co-exposed to (5, 50 500 ng/L) 60 d investigate on neurobehavior, histopathology, oxidative stress, mitochondrial function, neurotransmitters gene expression. The results co-exposure interfered with several behaviors (learning-memory, anxiety, fear, aggressive shoaling behavior) addition known producing stress disrupting energy. More intriguingly, caused retinal vacuolization apoptosis optic tectum zone, impacted phototransduction pathway, impaired optesthesia, neurotransmitter dysregulation, which might underlying resulting abnormalities. This study confirms pollution multiple by chronic aquatic environments can result toxicity, indicating prolonged ecosystems health require close attention.

Язык: Английский

Процитировано

0