Sub-Chronically Exposing Zebrafish (Danio Rerio) to Environmental Levels of Methomyl Induces Dysbiosis and Dysfunction of the Gut Microbiota

Опубликована: Янв. 1, 2024

The widespread use of carbamate pesticides has led to numerous environmental and health concerns, including water contamination perturbation endocrine homeostasis among organisms. However, there remains a paucity research elucidating the specific effects methomyl on gut microbial composition physiological functions. This study aimed investigate intricate relationship between changes in zebrafish bacterial communities intestinal function after 56 days sub-chronic exposure at environmentally relevant concentrations (0, 0.05, 0.10, 0.20 mg/L). Our findings reveal significant methomyl-induced morphological intestines, characterized by villi shortening breakage. Notably, down-regulated nutrient energy metabolism, drug metabolism 0.05−0.10 mg/L, while up-regulating cortisol, inflammation-related genes, apoptotic markers mg/L. These manifestations indicate stress imposition disruption microbiota equilibrium, impacting metabolic processes instigating low-grade inflammatory responses cascades. Importantly, significantly correlated with shifts taxa abundance, Shewanella, Rubrobacter, Acinetobacter, Bacillus, Luteolibacter, Nocardia, Defluviimonas, Bacteroides genus. In summary, our underscores potential adverse aquatic organisms, emphasizing necessity for further mitigate its repercussions ecosystem stability.

Язык: Английский

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Ecotoxicity Assessment of Emerging Contaminants (EC) in Fish: Effects, Trends, and Challenges

˜The œhandbook of environmental chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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Effect of Ph on Removing Single and Mixed Parabens and Halogenated Parabens from Water by Uv/H2o2 Process

Опубликована: Янв. 1, 2023

Adjusting pH values in the aqueous environment is of great significance for improving removal efficiency parabens and halo-parabens. In this study, 20 protonated deprotonated species were selected as models to investigate their pH-dependent mechanisms kinetics by UV/H2O2 process using density functional theory (DFT). Results found that have higher reactivity HO• than neutral due high electron cloud density. H atom abstraction (HAA) reactions on substitution groups are most favorable pathways species, while radical adduct formation (RAF) species. Single transfer (SET) can be neglected it becomes a viable route molecules. The total reaction rate constants range from 1.63×109 3.74 ×1010 M−1 s−1 at 7.0, confirming experimental results. Neutral weakly alkaline conditions degradation MeP halo-parabens process. order optimum di-halo-parabens > mono-halo-parabens ≈ F, F-MeP MeP. Furthermore, transformation products need further oxidative toxicity. Our findings provide new insights into removing halogenated derivatives wastewater.

Язык: Английский

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Fish larvae: an alternative animal model for testing the toxicity of food additives

Reviews in Biological and Biomedical Sciences, Год журнала: 2023, Номер 5(1), С. 19 - 27

Опубликована: Дек. 29, 2023

Concerns regarding the properties and potential hazardous effects of food additives are increasing.Food widely used because they improve taste, texture, color shelf life food.While commonly consumed worldwide, have begun to raise more concerns their impact on human health environment.Thus, new extensive but animal-minimized testing strategies needed highlight short-and long-term many additives.Thus, it was necessary find alternatives for toxicology studies, such as ex vivo/in vitro testing, embryos larvae that external fertilization embryonic or larval development.There studies usefulness non-mammalian models, fish larvae.Fish preferred in vivo numerous advantages, short-term development, transparent, genes, receptors molecular processes highly conserved between fish.In this review article we aimed tested toxic larvae, toxicological parameters establish toxicity most common anomalies caused by additives.

Язык: Английский

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