Uncovering the resistome and mobilome across different types of ready-to-eat fermented foods

Food Research International, Год журнала: 2025, Номер 213, С. 116577 - 116577

Опубликована: Май 5, 2025

Язык: Английский

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On qualitative properties of replication and transfer of conjugative plasmids encoding antibiotic resistance genes

Computational and Applied Mathematics, Год журнала: 2025, Номер 44(5)

Опубликована: Май 7, 2025

Язык: Английский

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A “Turn-on” Fluorescence Sensing Strategy Based on DNA-templated Silver Nanoclusters for the Detection of Antibiotic Resistance Genes

Analytica Chimica Acta, Год журнала: 2025, Номер unknown, С. 344170 - 344170

Опубликована: Май 1, 2025

Язык: Английский

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Understanding Stimulation of Conjugal Gene Transfer by Nonantibiotic Compounds: How Far Are We?

Environmental Science & Technology, Год журнала: 2024, Номер 58(21), С. 9017 - 9030

Опубликована: Май 16, 2024

A myriad of nonantibiotic compounds is released into the environment, some which may contribute to dissemination antimicrobial resistance by stimulating conjugation. Here, we analyzed a collection studies (i) identify patterns transfer stimulation across groups and concentrations chemicals, (ii) evaluate strength evidence for proposed mechanisms behind conjugal stimulation, (iii) examine plausibility alternative mechanisms. We show that stimulatory act at from 1/1000 1/10 minimal inhibitory concentration donor strain but always modest (less than 8-fold). The main via reactive oxygen species/SOS cascade and/or an increase in cell membrane permeability are not unequivocally supported literature. However, as most likely mechanism. This remains be confirmed firm molecular evidence. Such more standardized high-throughput conjugation assays needed create technologies solutions limit gene mitigating global antibiotic resistance.

Язык: Английский

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Occurrence and human exposure risk of antibiotic resistance genes in tillage soils of dryland regions: A case study of Northern Ningxia Plain, China

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 135790 - 135790

Опубликована: Сен. 10, 2024

Язык: Английский

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Mechanisms of Horizontal Gene Transfer and Viral Contribution to the Fate of Intracellular and Extracellular Antibiotic Resistance Genes in Anaerobic Digestion Supplemented with Conductive Materials under Ammonia Stress

Water Research, Год журнала: 2024, Номер 267, С. 122549 - 122549

Опубликована: Сен. 30, 2024

Язык: Английский

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Investigating the environmental dynamics of emerging pollutants in response to global climate change: Insights from bibliometrics-based visualization analysis

The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177758 - 177758

Опубликована: Ноя. 30, 2024

Язык: Английский

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High-Pressure Processing Influences Antibiotic Resistance Gene Transfer in Listeria monocytogenes Isolated from Food and Processing Environments

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12964 - 12964

Опубликована: Дек. 2, 2024

The study aimed to assess the high-pressure processing (HPP) impact on antibiotic resistance gene transfer in

Язык: Английский

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Deep-Sea Ecosystems as an Unexpected Source of Antibiotic Resistance Genes

Marine Drugs, Год журнала: 2024, Номер 23(1), С. 17 - 17

Опубликована: Дек. 31, 2024

The deep-sea ecosystem, a less-contaminated reservoir of antibiotic resistance genes (ARGs), has evolved for microbes to survive and utilize scarce resources. Research on the diversity distribution these in environments is limited. Our metagenomics study employed short-read-based (SRB) assembled-contig-based (ACB) methods identify ARGs waters sediments assess their potential pathogenicity. SRB prediction was found be more effective studying abundance genes, while combining both better illustrated relationship with hosts. Deep-sea (DSW) trenches had highest ARGs, including β-lactams, multidrug rifamycins. Mobile genetic elements, such as IncQ RP4 plasmids, were also identified. ratio nonsynonymous synonymous substitutions (pN/pS) values suggest different evolutionary strategies response conditions possible human impacts. These resistome profiles provide valuable insights into natural origins well ecological implications ecosystems. exploration global diverse novel approach that will assist understanding reservoirs mechanisms. Therefore, employing comprehensive particularly necessary. Unique microbial life ecosystems, especially cold seeps (DSCSS), (DSW), trench (TW), could source new antibiotics discovery.

Язык: Английский

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Cigarette smoking promotes the spread of antimicrobial resistance in the human lung and the environment

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 14, 2023

Abstract While immediate health risks of cigarette smoking are well-established, indirect impacts cigarette-derived pollutants through proliferation antimicrobial resistance (AMR) among bacteria remain understudied. Here, exposure to smoke condensate at relevant concentrations resulted in >2-fold elevated transfer rates a multi-drug-resistance encoding plasmid between Pseudomonas strains artificial lung sputum medium. This effect was connected reactive oxygen species production as part the bacterial stress response when exposed toxicants. Similar results were obtained under ash leachate environmental Further, used filters enriched toxic residues submerged wastewater stream, and colonized by altered microbial communities compared unused filters. These significantly pathogens AMR. Hence, could facilitate hitchhiking high-risk novel environments. We demonstrate that compounds can promote spread AMR within human natural

Язык: Английский

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