Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 7183 - 7204
Опубликована: Дек. 1, 2023
Abstract:
The
increasing
use
of
titanium
dioxide
nanoparticles
(TiO
2
NPs)
across
various
fields
has
led
to
a
growing
concern
regarding
their
environmental
contamination
and
inevitable
human
exposure.
Consequently,
significant
research
efforts
have
been
directed
toward
understanding
the
effects
TiO
NPs
on
both
humans
environment.
Notably,
exposure
associated
with
multiple
impairments
nervous
system.
This
review
aims
provide
an
overview
documented
neurotoxic
in
different
species
vitro
models.
Following
exposure,
can
reach
brain,
although
specific
mechanism
quantity
particles
that
cross
blood-brain
barrier
(BBB)
remain
unclear.
Exposure
shown
induce
oxidative
stress,
promote
neuroinflammation,
disrupt
brain
biochemistry,
ultimately
impair
neuronal
function
structure.
Subsequent
damage
may
contribute
behavioral
disorders
play
role
onset
progression
neurodevelopmental
or
neurodegenerative
diseases.
Moreover,
potential
be
influenced
by
factors,
including
characteristics
physicochemical
properties
NPs.
However,
systematic
comparison
under
conditions
is
still
lacking.
Additionally,
our
underlying
mechanisms
exerted
remains
incomplete
fragmented.
Given
these
knowledge
gaps,
it
imperative
further
investigate
hazards
risks
Keywords:
NPs,
effects,
damage,
Язык: Английский
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics
Environment International,
Год журнала:
2024,
Номер
192, С. 109012 - 109012
Опубликована: Сен. 17, 2024
Язык: Английский
Current research on ecotoxicity of metal-based nanoparticles: from exposure pathways, ecotoxicological effects to toxicity mechanisms
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Июль 15, 2024
Metal-based
nanoparticles
have
garnered
significant
usage
across
industries,
spanning
catalysis,
optoelectronics,
and
drug
delivery,
owing
to
their
diverse
applications.
However,
potential
ecological
toxicity
remains
a
crucial
area
of
research
interest.
This
paper
offers
comprehensive
review
recent
advancements
in
studying
the
ecotoxicity
these
nanoparticles,
encompassing
exposure
pathways,
toxic
effects,
mechanisms.
Furthermore,
it
delves
into
challenges
future
prospects
this
domain.
While
some
progress
has
been
made
addressing
issue,
there
is
still
need
for
more
assessments
fully
understand
implications
metal-based
on
environment
human
well-being.
Язык: Английский
Navigating Neurotoxicity and Safety Assessment of Nanocarriers for Brain Delivery: Evaluation Models and Insights
Acta Biomaterialia,
Год журнала:
2024,
Номер
189, С. 25 - 56
Опубликована: Сен. 20, 2024
Язык: Английский
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms
Srishti Parashar,
Sheetal Raj,
Priyanka Shrivastava
и другие.
Journal of Pharmacological and Toxicological Methods,
Год журнала:
2024,
Номер
unknown, С. 107563 - 107563
Опубликована: Сен. 1, 2024
Язык: Английский
Embryonic BPF exposure induces neurodevelopmental and neurobehavioral toxicity by affecting neural stem cell proliferation in Drosophila
Environmental Pollution,
Год журнала:
2025,
Номер
unknown, С. 125844 - 125844
Опубликована: Фев. 1, 2025
Язык: Английский
Transcriptomic analysis of Drosophila melanogaster larvae exposed to dimethyl phthalate reveals molecular insights into developmental retardation
Journal of Asia-Pacific Entomology,
Год журнала:
2025,
Номер
unknown, С. 102391 - 102391
Опубликована: Март 1, 2025
Язык: Английский
Potential impacts of titanium dioxide nanoparticles on the biochemical and behavioural status of the amphipods Talitrus saltator (Amphipoda, Talitridae)
Chemistry and Ecology,
Год журнала:
2024,
Номер
40(8), С. 859 - 878
Опубликована: Июнь 25, 2024
Titanium
dioxide
nanoparticles
(TiO2
NPs)
are
among
the
most
universally
engineered
nanomaterials
and
widely
used
in
world.
In
order
to
predict
environmental
impact
interaction
between
these
NPs
coastal
organisms,
amphipod
Talitrus
saltator
was
exposed
TiO2
C1
=
151.5
µg.L−1
C2
303
µg.L−1.
Catalase
activity
increased
significantly
reaches
a
maximum
of
about
0.8
±
0.02
µMol/min/mg
proteins
after
exposure
showing
possible
oxidative
mechanisms.
addition,
acetylcholinesterase
reduced
(p
<
0.05)
highest
concentration,
indicating
neurotransmission
disturbance
treated
with
NPs.
Locomotor
behaviour
for
untreated
specimens
studied
under
constant
darkness
(DD).
Results
revealed
existence
ultradian
circadian
components.
locomotor
patterns
were
generally
bimodal
became
multimodal
ones.
We
noted
also
slippage
peak
from
middle
subjective
night
control
until
day
exposure.
Furthermore,
important
stability
observed
individuals
who
more
active
than
Overall,
this
laboratory
study
provides
preliminary
toxicity
data
Язык: Английский