The
connection
between
mental
health
and
illicit
substance
use
disorder
is
intricate
poorly
understood
but
may
potentially
be
unraveled
by
examining
residues
of
antidepressants
drugs
through
wastewater-based
epidemiology
(WBE).
In
this
study,
we
assessed
time-dependent
intrinsic
correlations
(TDIC)
the
concentrations
their
metabolites
in
untreated
sewage
samples
during
three
sampling
campaigns,
from
September
2022
to
May
2024.
Notable
positive
(+medium
2022;
+weak
2023;
+medium
2024)
were
observed
(e.g.,
methamphetamine,
cocaine,
its
benzoylecgonine
metabolite)
bupropion
(an
antidepressant).
For
other
psychoactive
examined
(citalopram,
venlafaxine,
metabolite
desvenlafaxine),
with
2023
2024
campaigns.
This
first
time
WBE
demonstrates
interconnection
prescription
drugs,
such
as
antidepressants,
underscoring
TDIC's
strength
extracting
information
complementary
data.
We
applied
similar
data
analytics
using
antivirals
antibiotics
correlation
acetaminophen;
expected
results
obtained.
TDIC
acetaminophen
showed
a
strong
whole
event,
supporting
applicability
research.
Microchemical Journal,
Год журнала:
2023,
Номер
193, С. 109131 - 109131
Опубликована: Июль 26, 2023
The
occurrence
of
pharmaceuticals
in
influent
wastewater
samples
(IWW)
is
a
recurrent
issue.
monitoring
their
presence
not
only
valuable
from
an
environmental
point
view,
but
also
as
tool
to
analyze
patterns
human
use
by
the
so-called
wastewater-based
epidemiology.
development
analytical
method
based
on
solid-phase
extraction
followed
liquid
chromatography
coupled
tandem
mass
spectrometry
monitor
group
seventeen
including
most
representative
for
various
therapeutic
families
IWW
described
this
work.
were
collected
during
week
six
treatment
plants
located
different
cities
and
towns
across
Spain.
developed
provides
acceptable
figures
merit
with
apparent
recoveries
ranging
42%
139%,
low
matrix
effect
(in
general
lower
than
±
30%),
quantification
limits
(MQL)
between
1
ng/L
24
all
compounds,
except
atenolol
(58
ng/L).
All
studied
found
concentrations
<
MQL
10,393
ng/L,
being
highest
tramadol.
population
normalized
daily
loads
revealed
that
follows,
general,
similar
pattern
monitored.
Water Air & Soil Pollution,
Год журнала:
2024,
Номер
235(12)
Опубликована: Окт. 31, 2024
Abstract
This
paper
is
focused
on
an
overview
of
developments
and
validation
procedures
in
analytical
methods
for
the
detection
quantification
emerging
contaminants
from
multiple
groups
environmental
environment:
polyaromatic
hydrocarbons
(PAHs),
phthalate
esters
(PEs),
alkylphenol
ethoxylates
(APEOs),
alkylphenols
(APs),
butylated
hydroxytoluene
(BHT)
river
sediments.
Especially,
simultaneous
extraction
several
analyte
sediment
samples
currently
uncommon,
but
perspective
green
chemistry,
it
highly
desirable.
In
analysis,
substances
are
determined
at
once
instead
through
individual
analyses,
saving
energy,
time,
chemicals
while
significantly
increasing
laboratory
throughput.
review
reports
different
approaches
monitoring
presence
four
There
plenty
sampling
techniques,
with
core
grab
being
most
employed
present.
Sample
preparation
a
challenging
part
whole
method,
providing
ample
opportunity
optimization
accordance
chemistry
principles.
Various
schemes,
including
ultrasound-assisted
accelerated
solvent
extraction,
microwave-assisted
energy-intensive
techniques
may
be
considered
"green"
due
to
their
possibility
reduce
consumption
organic
solvents,
which
usually
toxic.
Quick,
Easy,
Cheap,
Effective,
Rugged
Safe
(QuEChERS)
case
satisfactory
parameters
well-evaluated
utilized.
The
recent
clean-up
analysis
two,
three
or
showing
promising
results.
Separation
shortly
discussed.
Further
optimizations
methodologies
needed,
future
field
expected
more
efficient
faster
acquisition
data
real
samples.
Journal of Xenobiotics,
Год журнала:
2024,
Номер
14(4), С. 1807 - 1825
Опубликована: Ноя. 21, 2024
Pharmaceutical
residues
in
aquatic
ecosystems
pose
significant
environmental
and
public
health
challenges.
Identifying
the
presence
levels
of
these
pharmaceuticals
is
crucial.
This
study
developed
an
analytical
method
to
detect
used
for
Alzheimer's
(AD)
Parkinson's
(PD)
disease,
including
psychiatric
drugs
stimulant
caffeine,
targeting
30
compounds.
Optimized
mass
spectrometric
liquid
chromatographic
parameters
enabled
robust
detection
quantification.
The
methodology
was
applied
25
surface
wastewater
samples.
Twenty-one
compounds
were
detected
eight
drugs,
five
metabolites
(citalopram
N-oxide,
citalopram
propionic
acid,
desmethylcitalopram,
