Microplastics and Oxidative Stress—Current Problems and Prospects

Antioxidants, Год журнала: 2024, Номер 13(5), С. 579 - 579

Опубликована: Май 8, 2024

Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community general public, as they threaten environment. contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, apoptosis. They affect cells, tissues, organs, overall health, potentially contributing conditions like cancer cardiovascular disease. pose a significant danger due their widespread occurrence food. In recent years, information has emerged indicating MPs can cause oxidative stress (OS), known factor accelerating aging organisms. This comprehensive evaluation exposed notable variability reported connection OS. work aims provide critical review whether harmfulness constitute environmental contaminants may result OS through analysis research existing literature, well an assessment characteristics causing Additionally, article covers analytical methodology used this field. The conclusions point necessity for further into effects on

Язык: Английский

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Immune and inflammatory responses of human macrophages, dendritic cells, and T-cells in presence of micro- and nanoplastic of different types and sizes

Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132194 - 132194

Опубликована: Июль 31, 2023

Язык: Английский

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Microplastic and PTFE contamination of food from cookware

The Science of The Total Environment, Год журнала: 2024, Номер 929, С. 172577 - 172577

Опубликована: Апрель 18, 2024

Microplastics are a prolific environmental contaminant that have been evidenced in human tissues. Human uptake of microplastic occurs via inhalation airborne fibres and ingestion microplastic-contaminated foods beverages. Plastic PTFE-coated cookware food contact materials may release micro- nanoplastics into during preparation. In this study, the extent to which non-plastic, new plastic old releases microplastics prepared is investigated. Jelly used as simulant, undergoing series processing steps including heating, cooling, mixing, slicing storage replicate preparation undertaken home kitchens. Using non-plastic did not introduce simulant. Conversely, using resulted significant increases contamination. comprised PTFE, polyethylene polypropylene particulates fibrous particles, ranging 13-318 μm. Assuming meal was daily per prescribed methodology, be contributing 2409-4964 annum homecooked food. The health implications ingesting remains unclear.

Язык: Английский

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Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence

Cells, Год журнала: 2024, Номер 13(21), С. 1788 - 1788

Опубликована: Окт. 29, 2024

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, increasing industrial production have led to questions about their long-term impact on human animal health. This narrative review describes the effects of MNPs oxidative stress, inflammation, aging. Exposure leads increased reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, systems. ROS can cause damage cellular macromolecules such as DNA, proteins, lipids. Direct interaction between immune cells or an indirect result stress-mediated may lead pro-inflammatory cytokines throughout different MNP-exposure conditions. inflammatory response is a common feature in pathogenesis neurodegenerative, cardiovascular, other age-related diseases. also act senescence inducers by promoting mitochondrial dysfunction, impairing autophagy, activating DNA responses, exacerbating aging altogether. Increased reproductive transfer MNPs/induced damages from parents offspring animals further corroborates transgenerational health risks tiny particles. aims provoke deeper investigation into notorious these pervasive particles well-being longevity.

Язык: Английский

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Microplastic particles in human blood and their association with coagulation markers

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 6, 2024

Recent studies have indicated potential health risks associated with microplastics (MPs) exposure, including alterations in blood coagulation homeostasis. This cross-sectional study aimed to quantitatively examine MPs human and assess their association markers. We recruited 36 healthy adults, collected whole samples, analyzed using Fourier-transform infrared (µ-FTIR) spectroscopy. Lifestyle factors related MP exposure were assessed, such as the use of plastic food containers. Coagulation inflammatory markers samples analyzed, C-reactive protein, prothrombin time, activated partial time (aPTT), antithrombin III, platelet count, erythrocyte sedimentation rate, fibrinogen. detected 88.9% participants, a mean concentration 4.2 MPs/mL. The predominant types plastics identified polystyrene polypropylene. significantly higher participants greater A high load (≥ 3 MPs/mL) was correlated increased aPTT, blood, specific lifestyle factors, significant underscores need for strategies reduce MPs, particularly relation cardiovascular risks.

Язык: Английский

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Predictive metabolomic signatures for safety assessment of three plastic nanoparticles using intestinal organoids

The Science of The Total Environment, Год журнала: 2023, Номер 913, С. 169606 - 169606

Опубликована: Дек. 28, 2023

Язык: Английский

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Toxicological impacts of microplastics on human health: a bibliometric analysis

Environmental Science and Pollution Research, Год журнала: 2023, Номер 31(46), С. 57417 - 57429

Опубликована: Ноя. 8, 2023

Язык: Английский

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Real-time and specific monitoring of nitric oxide and evaluating of the oxidative stress in living cells and zebrafish under the pollutant exposure using a carbon dot-based composite fluorescent probe

Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134558 - 134558

Опубликована: Май 8, 2024

Язык: Английский

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Effects of microplastics on chemo-resistance and tumorigenesis of colorectal cancer

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Язык: Английский

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Biological Effects of Micro-/Nano-Plastics in Macrophages

Nanomaterials, Год журнала: 2025, Номер 15(5), С. 394 - 394

Опубликована: Март 4, 2025

The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.

Язык: Английский

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