The Open Biotechnology Journal,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 10, 2023
Background:
Epidemiological
studies
have
shown
that
elevated
levels
of
air
pollutants
are
associated
with
various
adverse
health
effects,
including
infertility.
Objective:
We
aimed
to
assess
the
protective
effects
aqueous
Urtica
dioica
leaf
extract
against
benzo[a]pyrene
-induced
oxidative
damage
in
mouse
testis.
Methods:
Mice
exposed
were
treated
or
without
for
five
weeks,
and
changes
body
testes
weights,
messenger
RNA
activities
antioxidant
enzymes,
plasma
testosterone
levels,
sperm
characteristics,
testicular
tissue
histology
determined.
Results:
Exposure
remarkably
reduced
testis
expression
activity
increased
lipid
peroxidation,
decreased
count
motility,
affected
morphology
viability,
damaged
seminiferous
tubules.
Treatment
attenuated
stress
by
increasing
genes.
Further,
antioxidative
enzyme
activity,
enhanced
improved
Conclusion:
Aqueous
protects
from
could
potentially
reverse
The
impact
of
polycyclic
aromatic
hydrocarbons
(PAHs)
on
lung
function
has
garnered
attention,
but
studies
mostly
focus
individual
effect.
This
study
investigates
urinary
PAH
metabolites
as
biomarkers
exposure
and
assesses
the
relationships
between
single
combined
exposures
to
nine
in
adults.
Data
from
4040
adults
2007–2012
National
Health
Nutrition
Examination
Survey
(NHANES)
were
analyzed.
Weighted
generalized
linear
models
estimated
effects
function.
Additionally,
weighted
quantile
sum
(WQS)
regression,
g-computation
(qgcomp),
Bayesian
kernel
machine
regression
(BKMR)
employed
evaluate
impacts
multiple
metabolites.
Analyses
revealed
negative
associations
with
function,
excluding
forced
vital
capacity
(FVC).
WQS,
qgcomp,
BKMR
consistently
showed
that
was
associated
decrease.
WQS
indicated
2-hydroxynaphthalene
(2-NAP)
largest
contributor
reductions
expiratory
volume
1
s
(FEV1),
FVC,
peak
flow
(PEF),
25
75%
FVC
(PEF25-75%).
1-hydroxypyrene
(1-PYR)
primary
metabolite
contributing
decreases
FEV1/FVC
fractional
exhaled
nitric
oxide
(FeNO).
effect
did
not
affect
current
smokers
or
FeNO
nonsmokers,
decreased
smokers.
strengthens
Given
limitations
this
study,
including
lack
knowledge
other
pathways
uncertainty
metabolites,
further
research
is
necessary
explore
mechanisms
underlying
these
address
assessment.
The Open Biotechnology Journal,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 10, 2023
Background:
Epidemiological
studies
have
shown
that
elevated
levels
of
air
pollutants
are
associated
with
various
adverse
health
effects,
including
infertility.
Objective:
We
aimed
to
assess
the
protective
effects
aqueous
Urtica
dioica
leaf
extract
against
benzo[a]pyrene
-induced
oxidative
damage
in
mouse
testis.
Methods:
Mice
exposed
were
treated
or
without
for
five
weeks,
and
changes
body
testes
weights,
messenger
RNA
activities
antioxidant
enzymes,
plasma
testosterone
levels,
sperm
characteristics,
testicular
tissue
histology
determined.
Results:
Exposure
remarkably
reduced
testis
expression
activity
increased
lipid
peroxidation,
decreased
count
motility,
affected
morphology
viability,
damaged
seminiferous
tubules.
Treatment
attenuated
stress
by
increasing
genes.
Further,
antioxidative
enzyme
activity,
enhanced
improved
Conclusion:
Aqueous
protects
from
could
potentially
reverse
