The Open Biotechnology Journal,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 10, 2023
Background:
Epidemiological
studies
have
shown
that
elevated
levels
of
air
pollutants
are
associated
with
various
adverse
health
effects,
including
infertility.
Objective:
We
aimed
to
assess
the
protective
effects
aqueous
Urtica
dioica
leaf
extract
against
benzo[a]pyrene
-induced
oxidative
damage
in
mouse
testis.
Methods:
Mice
exposed
were
treated
or
without
for
five
weeks,
and
changes
body
testes
weights,
messenger
RNA
activities
antioxidant
enzymes,
plasma
testosterone
levels,
sperm
characteristics,
testicular
tissue
histology
determined.
Results:
Exposure
remarkably
reduced
testis
expression
activity
increased
lipid
peroxidation,
decreased
count
motility,
affected
morphology
viability,
damaged
seminiferous
tubules.
Treatment
attenuated
stress
by
increasing
genes.
Further,
antioxidative
enzyme
activity,
enhanced
improved
Conclusion:
Aqueous
protects
from
could
potentially
reverse
Indoor Air,
Год журнала:
2024,
Номер
2024, С. 1 - 13
Опубликована: Апрель 23, 2024
Nitropolycyclic
aromatic
hydrocarbon
(NPAH)
emissions
from
the
combustion
of
household
solid
fuel
may
cause
great
harm
to
public
health.
Children
are
one
most
susceptible
population
groups
at
risk
indoor
air
pollutants
due
their
immature
respiratory
and
immune
systems.
In
this
study,
a
primary
school
using
coal
for
heating
in
winter
was
selected
forty
participants
were
randomly
recruited
among
schoolchildren.
Fine
particulate
matter
samples
collected
by
both
individual
portable
samplers
fixed
middle-flow
during
nonheating
seasons.
The
NPAH
concentrations
PM2.5
analyzed
gas
chromatograph
coupled
mass
spectrometer.
Potential
sources
NPAHs
identified
ratios
as
well
principal
component
analysis.
Lung
function
children
tested
an
electronic
spirometer.
relationship
between
exposure
level
children’s
lung
studied.
Finally,
cancer
caused
inhalation
assessed.
results
showed
significantly
higher
season
(
ng·m-3)
than
that
id="M2">0.094±0.107
ng·m-3).
Coal/biomass
secondary
formation
potential
season.
Significantly
lower
also
found
compared
with
As
result
Monte
Carlo
simulation,
averaged
incremental
lifetime
(ILCR)
values
seasons
id="M3">3.50×10−8
id="M4">2.13×10−8
,
respectively.
Our
research
revealed
association
confirmed
adverse
effect
combustion.
indicated
further
control
strategies
on
needed
reduce
protect
The Open Biotechnology Journal,
Год журнала:
2023,
Номер
17(1)
Опубликована: Окт. 10, 2023
Background:
Epidemiological
studies
have
shown
that
elevated
levels
of
air
pollutants
are
associated
with
various
adverse
health
effects,
including
infertility.
Objective:
We
aimed
to
assess
the
protective
effects
aqueous
Urtica
dioica
leaf
extract
against
benzo[a]pyrene
-induced
oxidative
damage
in
mouse
testis.
Methods:
Mice
exposed
were
treated
or
without
for
five
weeks,
and
changes
body
testes
weights,
messenger
RNA
activities
antioxidant
enzymes,
plasma
testosterone
levels,
sperm
characteristics,
testicular
tissue
histology
determined.
Results:
Exposure
remarkably
reduced
testis
expression
activity
increased
lipid
peroxidation,
decreased
count
motility,
affected
morphology
viability,
damaged
seminiferous
tubules.
Treatment
attenuated
stress
by
increasing
genes.
Further,
antioxidative
enzyme
activity,
enhanced
improved
Conclusion:
Aqueous
protects
from
could
potentially
reverse
