Polyethylene Terephthalate Microplastic Exposure Induced Reproductive Toxicity Through Oxidative Stress and p38 Signaling Pathway Activation in Male Mice

Toxics, Год журнала: 2024, Номер 12(11), С. 779 - 779

Опубликована: Окт. 25, 2024

Polyethylene terephthalate (PET) is a type of polymer plastic that often used to make bags, bottles, and clothes. However, the waste such products decomposed into microplastics (MPs), which are fragments smaller than 5 mm, by various external forces as wind, UV radiation, mechanical wear, biodegradation. PET MPs have been widely detected in environment human tissue samples; however, toxicity mechanism mammals still unclear. In this study, we investigated male reproductive their underlying mechanism. A total 80 mice were orally exposed 0.01, 0.1, 1 mg/d (with diameter μm) for 42 days. The results showed μm induced different degrees pathological damage testicular tissues, decreased sperm quality, increased apoptosis spermatogenic cells via oxidative stress p38 signaling pathway activation. To further illustrate verify mechanistic pathway, was antagonized using N-acetylcysteine (NAC), activation blocked SB203580. revealed injury effects after exposure significantly ameliorated. Specifically, lesions relieved, quality improved, decreased. These demonstrated MP through pathway. This study provides new insights males, well valuable references public health protection strategies.

Язык: Английский

Microplastic in fishes: the first report from a Himalayan River — Alaknanda

Environmental Science and Pollution Research, Год журнала: 2023, Номер 31(1), С. 1637 - 1643

Опубликована: Ноя. 30, 2023

Язык: Английский