Medical Research Archives,
Год журнала:
2023,
Номер
11(12)
Опубликована: Янв. 1, 2023
Background:
This
perspective
concerning
hepatoxicity
of
per-
and
polyfluoroalkyl
substances
(PFAS)
aims
to
provide
a
current
understanding
the
damage
reasonable
clinician
responses
needs
concerned
patients
affected
communities.
Methods:
Search
strategy
included
PFAS
following:
human
liver
toxicity/disease;
relevant
biomarkers
including
transaminases,
lipids,
uric
acid;
predictive
equations
(for
disease),
imaging
modalities,
histologic
findings.
Experimental
data
outcomes
disrupted
hepatic
metabolic
pathways
was
also
reviewed.
Recommended
clinical
approaches
communities
sought
in
both
National
Library
Medicine
organizational
websites.
Results:
Several
reliably
cause
adverse
changes
biomarkers,
with
strong
consistency
between
experimental
data.
Adverse
population
include
cholesterol
LDL
cholesterol,
acid.
biomarker
triad
suggests
that
mechanisms
are
or
resemble
associated
steatotic
disease,
which
is
found
across
species
following
exposure.
Human
studies
sparse
mostly
support
inference
toxicant
resembles
pathway
can
lead
from
steatosis
more
serious
stages
disease
due
metabolism
fatty
acids.
Advice
clinicians
reviewed
various
agencies
nonprofits
organizations
committee
US
Academies
Sciences,
Engineering,
Medicine,
nonprofit/university
collaboration
REACH.
Discussion:
Converging
lines
evidence
indict
as
(and
trans-species)
hepatotoxins
continuum
nature
injury.
Increases
abnormal
transaminases
sparser
biopsy
findings
clinically
important
contributing
public
health
problem.
It
still
challenging
decide
many
definitively
is/are
most
Many
use
remain
virtually
unstudied,
research
emergency.
Simple
concerns
heavily
contaminated
communities,
within
capabilities
offices,
The
fate
of
per-
and
polyfluoroalkyl
substances
(PFAS)
was
evaluated
at
a
site
where
municipal
biosolids
have
been
applied
annually
for
38
years
as
waste
management
strategy.
Soil
cores
(1.8
m
in
30-cm
sections),
groundwater
from
four
wells,
2022
were
analyzed
PFAS
(54
targeted,
17
semi-quantified)
using
liquid
chromatography
high
resolution
mass
spectrometry
including
suspect
screening.
Total
concentrations
decreased
with
soil
depth
1700
ng/g
to
2.06
ng/g.
distribution
60
mol%
perfluoroalkyl
acid
(PFAA)
precursors
intermediates.
surface
dominated
by
long-chain
PFAAs
(67-76
mol%)
reflecting
precursor
degradation
after
application.
Presence
semi-quantified
intermediates
further
reflects
soil.
Long-chain
diminished
while
short-chain
increased
up
94
91
the
bottom
groundwater,
respectively.
is
consistent
chain-length
dependent
sorption-impacted
transport
organic
carbon
content
(15.2%
OC)
which
subsequently
(~2-3%
OC
>
cm).
High
upper
horizon
likely
decades
application
rates,
contributed
minimizing
leaching
PFAS.
While
well
within
dedicated
land
disposal
not
drinking
water,
comparison
only,
this
only
marginally
exceeded
EU
water
directive
total
few
individual
PFAS,
but
did
exceed
tenfold,
USEPA
standard
PFOA.
Journal of Food Science,
Год журнала:
2024,
Номер
89(10), С. 6774 - 6786
Опубликована: Сен. 1, 2024
Ingestion
of
perfluoroalkyl
acids
(PFAAs)
via
contaminated
food
contact
materials
(FCMs)
is
an
important
human
exposure
source.
This
study
adopts
a
toxicity
equivalent
approach
to
evaluate
the
collective
health
risk
multiple
PFAAs
in
FCMs.
A
comprehensive
extraction
and
analysis
21
FCMs
was
performed.
Among
analyzed
substances,
15
were
detected.
Migration
experiment
using
three
simulants
revealed
migration
range
seven
from
into
simulant
be
0.47-46.7
ng/cm
Toxicological Sciences,
Год журнала:
2024,
Номер
202(1), С. 36 - 49
Опубликована: Авг. 13, 2024
Abstract
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
synthetic
chemicals
known
for
their
environmental
persistence
resistance
to
biodegradation.
This
study
investigated
the
impact
of
adolescent
exposure
a
PFAS
mixture
on
adult
ovarian
function.
Female
CD-1
mice
were
orally
exposed
vehicle
control
or
(comprised
perfluorooctanoic
acid,
perfluorooctanesulfonic
undecafluoro-2-methyl-3-oxahexanoic
perfluorobutanesulfonic
acid)
15
d.
After
42-d
recovery
period,
reproductive
hormones,
fibrosis,
gene
protein
expression
analyzed
using
ELISA,
Picrosirius
red
staining,
qPCR,
immunoblotting,
respectively.
Results
revealed
that
did
not
affect
body
organ
weight,
although
weight
slightly
decreased.
PFAS-exposed
exhibited
disturbed
estrous
cycle,
with
less
time
spent
in
proestrus
than
mice.
Follicle
counting
indicated
reduction
primordial
primary
follicles.
Serum
analysis
no
changes
steroid
follicle-stimulating
hormone,
anti-Müllerian
but
significant
increase
luteinizing
hormone
was
observed
PFAS-treated
Ovaries
collected
from
had
increased
mRNA
transcripts
steroidogenic
enzymes
fatty
acid
synthesis-related
genes.
also
collagen
content
ovary.
Additionally,
serum
tumor
necrosis
factor-α
levels
higher
Finally,
abundance
Hippo
pathway
components
upregulated
ovaries
Overall,
these
findings
suggest
can
disrupt
function
adulthood.
Medical Research Archives,
Год журнала:
2023,
Номер
11(12)
Опубликована: Янв. 1, 2023
Background:
This
perspective
concerning
hepatoxicity
of
per-
and
polyfluoroalkyl
substances
(PFAS)
aims
to
provide
a
current
understanding
the
damage
reasonable
clinician
responses
needs
concerned
patients
affected
communities.
Methods:
Search
strategy
included
PFAS
following:
human
liver
toxicity/disease;
relevant
biomarkers
including
transaminases,
lipids,
uric
acid;
predictive
equations
(for
disease),
imaging
modalities,
histologic
findings.
Experimental
data
outcomes
disrupted
hepatic
metabolic
pathways
was
also
reviewed.
Recommended
clinical
approaches
communities
sought
in
both
National
Library
Medicine
organizational
websites.
Results:
Several
reliably
cause
adverse
changes
biomarkers,
with
strong
consistency
between
experimental
data.
Adverse
population
include
cholesterol
LDL
cholesterol,
acid.
biomarker
triad
suggests
that
mechanisms
are
or
resemble
associated
steatotic
disease,
which
is
found
across
species
following
exposure.
Human
studies
sparse
mostly
support
inference
toxicant
resembles
pathway
can
lead
from
steatosis
more
serious
stages
disease
due
metabolism
fatty
acids.
Advice
clinicians
reviewed
various
agencies
nonprofits
organizations
committee
US
Academies
Sciences,
Engineering,
Medicine,
nonprofit/university
collaboration
REACH.
Discussion:
Converging
lines
evidence
indict
as
(and
trans-species)
hepatotoxins
continuum
nature
injury.
Increases
abnormal
transaminases
sparser
biopsy
findings
clinically
important
contributing
public
health
problem.
It
still
challenging
decide
many
definitively
is/are
most
Many
use
remain
virtually
unstudied,
research
emergency.
Simple
concerns
heavily
contaminated
communities,
within
capabilities
offices,
