Medical Research Archives, Год журнала: 2023, Номер 11(12)
Опубликована: Янв. 1, 2023
Background: This perspective concerning hepatoxicity of per- and polyfluoroalkyl substances (PFAS) aims to provide a current understanding the damage reasonable clinician responses needs concerned patients affected communities. Methods: Search strategy included PFAS following: human liver toxicity/disease; relevant biomarkers including transaminases, lipids, uric acid; predictive equations (for disease), imaging modalities, histologic findings. Experimental data outcomes disrupted hepatic metabolic pathways was also reviewed. Recommended clinical approaches communities sought in both National Library Medicine organizational websites. Results: Several reliably cause adverse changes biomarkers, with strong consistency between experimental data. Adverse population include cholesterol LDL cholesterol, acid. biomarker triad suggests that mechanisms are or resemble associated steatotic disease, which is found across species following exposure. Human studies sparse mostly support inference toxicant resembles pathway can lead from steatosis more serious stages disease due metabolism fatty acids. Advice clinicians reviewed various agencies nonprofits organizations committee US Academies Sciences, Engineering, Medicine, nonprofit/university collaboration REACH. Discussion: Converging lines evidence indict as (and trans-species) hepatotoxins continuum nature injury. Increases abnormal transaminases sparser biopsy findings clinically important contributing public health problem. It still challenging decide many definitively is/are most Many use remain virtually unstudied, research emergency. Simple concerns heavily contaminated communities, within capabilities offices,
Язык: Английский