Abstract.
China
has
long-term
high
PM2.5
levels,
and
its
Oxidative
Potential
(OP)
is
worth
studying
as
it
may
unravel
the
impacts
of
aerosol
pollution
on
public
health
better
than
alone.
OP
are
influenced
by
meteorological
factors,
anthropogenic
emissions
sources
atmospheric
aging.
Although
their
impact
have
been
studied,
measurements
only
recently
became
available
a
limited
scale,
they
require
considerable
technical
expertise
resources.
For
this,
joint
relationship
between
for
wide
range
conditions
profiles
remain
elusive.
Towards
we
estimated
over
using
Danish
Eulerian
Hemispheric
Model
(DEHM)
system
with
input
from
WRF
weather
forecast
model.
It
was
found
that
higher
values
were
primarily
concentrated
in
urban
agglomerations
central
eastern
regions
China,
while
lower
western
northeastern
regions.
Furthermore,
probability
density
function
revealed
about
40
%
areas
had
an
annual
average
concentrations
exceeding
Chinese
limit;
36
below
1
𝑛𝑚𝑜𝑙
𝑚𝑖𝑛−1
𝑚−3,
41
2
23
above
𝑚−3.
Analysis
simulations
indicate
emission
contributed
46
(65
%)
54
(35
to
concentration
variability.
The
sensitivity
analysis
also
highlighted
levels
mostly
determined
secondary
formation
biomass
burning.
Environmental Chemistry,
Год журнала:
2025,
Номер
22(1)
Опубликована: Янв. 31, 2025
Environmental
context
Metals
in
airborne
particles
can
interact
with
lung
fluids
once
are
inhaled.
Water
solubility
of
particle-bound
metals
is
often
used
to
define
their
bioavailability.
We
show
that
exhibit
a
complex
dissolution
kinetics
surrogate
fluid,
and
driven
by
the
fluid
composition,
only
minor
extent
atmospheric
aqueous
phase
processing
aerosols.
Rationale
inhaled
cause
oxidative
stress.
Their
potential
dependent
on
fluids.
Methodology
In
this
study,
we
collected
PM2.5
samples
from
city
Padova
(Italy),
northern
Italian
Po
Valley.
investigated
epithelial
lining
(SELF)
compared
results
those
obtained
for
fog
water.
Results
found
most
elements
present
characterised
three
phases:
(1)
immediate
dissolution,
(2)
first-order
(3)
precipitation.
observed
speciation
metal
ions
SELF
influences
each
element.
also
influence
SELF.
Discussion
The
study
showed
composition
main
driver
processing.
Therefore,
bioavailability
mainly
determined
biological
composition.
E3S Web of Conferences,
Год журнала:
2025,
Номер
628, С. 01023 - 01023
Опубликована: Янв. 1, 2025
Transition
metal
ions
(TMIs)
are
effective
catalysts
for
atmospheric
multiphase
reactions
that
produces
secondary
air
pollutants.
The
reactivity
of
TMIs
depends
on
many
factors,
including
metal's
solubility
and
aqueous
speciation,
which
can
be
complex
in
the
urban
pollution
conditions.
In
this
study,
we
examined
speciation
Cu(II)
within
fine
particulate
matters
(PM
2.5
)
Beijing
pollution.
Using
visual
MINTEQ
model
PM
composition
data
obtained
from
previous
publications,
predicted
distribution
forms
free
ions,
metal-organic
complexes,
metal-inorganic
complexes.
Such
a
is
affected
by
pH
with
seasonal
variation,
may
further
arise
anthropogenic
emission
patterns.
Our
finding
provide
useful
dataset
parameterizing
kinetics
TMI-catalyzed
reactions.
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103305 - 103305
Опубликована: Авг. 8, 2024
Extensive
efforts
have
been
conducted
in
the
search
for
new
targetable
drivers
of
lung
squamous
cell
carcinoma
(LUSC);
to
date,
however,
candidates
remain
mostly
unsuccessful.
One
oncogenic
pathways
frequently
found
be
active
LUSC
is
NFE2L2
(NRF2
transcription
factor),
levels
which
are
regulated
by
KEAP1.
Mutations
or
KEAP1
trigger
NRF2
activation,
an
essential
protector
against
reactive
oxygen
species
(ROS).
We
hypothesized
that
frequency
activation
(∼35
%)
may
reflect
a
sensitivity
ROS.
Results
from
this
study
reveal
whereas
tumors
containing
forms
were
protected,
ROS
induction
wild-type
NFE2L2/KEAP1
cells
triggered
ferroptosis.
The
mechanism
action
normal-NRF2
involved
transient
miR-126-3p/miR-126-5p
upregulation,
and
reduction
p85β
SETD5
levels.
pentose
pathway
gene
increase
toxic
values.
Simultaneous
depletion
