Journal of Leukocyte Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 9, 2024
The
liver
has
critical
digestive,
metabolic,
and
immunosurveillance
roles,
which
get
disrupted
during
diseases
such
as
viral
hepatitis,
fatty
disease,
hepatocellular
carcinoma.
While
previous
research
on
the
pathological
development
of
these
focused
liver-resident
immune
populations,
Kupffer
cells,
infiltrating
cells
responding
to
pathogens
disease
also
play
crucial
roles.
Neutrophils
are
one
key
population
contributing
hepatic
inflammation
progression.
Belonging
initial
waves
response
threats,
neutrophils
suppress
bacterial
spread
acute
infections,
have
homeostasis-restoring
functions.
Whereas
chronic
insults,
they
display
their
plastic
nature
by
inflammatory
environment
develop
new
phenotypes
alongside
longer
lifespans.
This
review
summarizes
diversity
in
neutrophil
function
subpopulations
present
at
steady
state,
cancer.
Environment International,
Год журнала:
2025,
Номер
196, С. 109316 - 109316
Опубликована: Фев. 1, 2025
Although
microplastics
have
been
detected
in
human
blood,
placenta
and
other
tissues.
In
this
study,
for
the
first
time,
we
characterized
presence
variation
of
microplastic
deposition
patterns
three
skeletal
tissues,
namely
bone,
cartilage,
intervertebral
discs.
Forty
fragments
were
observed
24
samples
from
disc,
ranging
25.44
to
407.39
μm
diameter.
The
abundance
disc
(61.1
±
44.2
particles/g)
was
higher
than
those
bone
(22.9
15.7
cartilage
tissue
(26.4
17.6
particles/g).
average
sizes
discs
(159.5
103.8
μm)
(138.86
105.67
larger
that
(87.5
30.7
μm).
most
frequently
identified
polymers
polypropylene
(35
%),
ethylene
vinyl
acetate
copolymer
(30
polystyrene
(20
%).
vivo
experiment
suggested
invaded
through
blood
circulation
after
4
weeks
exposure.
Serum
levels
tumor
necrosis
factor-α
(TNF-α),
Type
Ⅰ
procollagen
amino-terminal
peptide
(PINP),
tartrate-resistant
acid
phosphatase-5b
(TRACP-5b)
elevated
compared
with
control
group
(p
<
0.05).
Our
study
suggests
invade
supply,
causing
distinct
accumulation
these
regions.
Microplastic
invasion
can
affect
health
by
influencing
expression
inflammatory
morphogenetic
cytokines.
These
findings
provide
insights
into
investigating
impact
on
health.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116818 - 116818
Опубликована: Июль 30, 2024
Microplastics
(MPs)
have
been
detected
in
various
human
tissues.
However,
whether
MPs
can
accumulate
within
tumors
and
how
they
affect
the
tumor
immune
microenvironment
(TIME)
therapeutic
responses
remains
unclear.
This
study
aimed
to
determine
presence
of
their
potential
effects
on
TIME.
Sixty-one
samples
were
collected
for
analysis.
The
was
qualitatively
quantitatively
assessed
using
pyrolysis-gas
chromatography-mass
spectrometry.
26
examined.
Three
types
identified:
polystyrene,
polyvinyl
chloride,
polyethylene.
In
lung,
gastric,
colorectal,
cervical
tumors,
MP
detection
rates
80
%,
40
50
17
%
(7.1-545.9
ng/g),
respectively.
70
pancreatic
(18.4-427.1
ng/g)
but
not
esophageal
tumors.
cancer,
MP-infiltrated
TIME
exhibited
a
reduction
CD8
Environmental Science and Pollution Research,
Год журнала:
2024,
Номер
31(20), С. 28890 - 28904
Опубликована: Апрель 2, 2024
Abstract
Inappropriate
disposal
of
plastic
wastes
and
their
durability
in
nature
cause
uncontrolled
accumulation
land/marine
ecosystems,
also
causing
destructive
effects
by
bioaccumulating
along
the
food
chain.
Microplastics
may
chronic
inflammation
relation
to
permanent
structures,
especially
through
oxidative
stress
cytotoxic
cellular
damage,
which
could
increase
risk
cancer
development.
The
microplastics
liver
is
a
major
concern,
therefore,
identification
mechanisms
hepatotoxic
great
importance.
Polymethyl
methacrylate
(PMMA)
widely
used
thermoplastic.
It
has
been
determined
that
PMMA
disrupts
lipid
metabolism
various
aquatic
organisms
causes
reproductive
developmental
toxicity.
PMMA-induced
humans
have
not
yet
clarified.
In
our
study,
toxic
(in
range
3–10
μm)
on
human
were
investigated
using
HepG2/THP-1
macrophage
co-culture
model,
sensitive
immune-mediated
injury
model.
Cellular
uptake
micro-sized
cells
was
done
transmission
electron
microscopy.
Determination
its
cell
viability
inflammatory
response,
stress,
with
gene
protein
expression
levels
play
role
mechanism
pathways
underlying
investigated.
results
concluded
inflammation,
disruptions
should
be
focus
attention
as
important
hepatotoxicity.
Our
points
out
potential
adverse
health,
supports
literature
information
subject.
Nanomaterials,
Год журнала:
2025,
Номер
15(5), С. 394 - 394
Опубликована: Март 4, 2025
The
environmental
impact
of
plastics
is
worsened
by
their
inadequate
end-of-life
disposal,
leading
to
the
ubiquitous
presence
micro-
(MPs)
and
nanosized
(NPs)
plastic
particles.
MPs
NPs
are
thus
widely
present
in
water
air
inevitably
enter
food
chain,
with
inhalation
ingestion
as
main
exposure
routes
for
humans.
Many
recent
studies
have
demonstrated
that
gain
access
several
body
compartments,
where
they
taken
up
cells,
increase
production
reactive
oxygen
species,
lead
inflammatory
changes.
In
most
tissues,
resident
macrophages
engage
first
approach
foreign
materials,
this
interaction
largely
affects
subsequent
fate
material
possible
pathological
outcomes.
On
other
hand,
organizers
controllers
both
responses
tissue
repair.
Here,
we
aim
summarize
available
information
on
NPs.
Particular
attention
will
be
devoted
consequences
macrophage
viability
functions,
well
implications
pathology.
Immunology Letters,
Год журнала:
2025,
Номер
272, С. 106976 - 106976
Опубликована: Фев. 1, 2025
Plastics
are
everywhere.
It
is
widely
recognized
that
they
represent
a
global
problem,
the
extent
of
which
yet
to
be
defined.
Humans
broadly
exposed
plastics,
whose
effects
and
consequences
poorly
characterized
so
far.
The
main
route
exposure
via
alimentary
respiratory
intake.
pollutions
may
come
from
both:
water
food
contamination
itself,
their
packaging.
smaller
sizes
(i.e.
microplastics
<150
µm
-
MPs)
considered
most
pervasive
living
organisms
and,
therefore,
potentially
harmful.
As
humans
occupy
one
apex
positions
chain,
we
bioaccumulation
biomagnification
MPs.
In
fact,
MPs
commonly
found
in
human
stools
blood.
However,
there
no
data
available
on
ability
accumulate
produce
detrimental
biological
systems.
Even
though
plastics
pollution
studied
mammals,
including
humans,
appear
have
inflammatory
effects,
rather
concerning
as
many
etiologies
disease
based
pro-inflammatory
status.
Molecular & Cellular Toxicology,
Год журнала:
2025,
Номер
21(2), С. 387 - 397
Опубликована: Фев. 27, 2025
Given
the
global
increase
in
obesity,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
major
health
concern.
Because
primary
organ
for
xenobiotic
metabolism,
impact
of
environmental
stressors
on
homeostasis
and
MASLD
has
garnered
significant
interest
over
past
few
decades.
The
concept
metabolism-disrupting
chemicals
(MDCs)
been
introduced
to
underscore
importance
factors
homeostasis.
Recent
epidemiological
biological
studies
suggest
causal
link
between
exposure
MDCs
prevalence
progression
MASLD.
This
review
aims
introduce
emerging
their
representative
toxic
mechanisms.
In
particular,
this
focuses
broadening
understanding
impacts
or
steatohepatitis
(MASH)
progression.
research
highlighted
contaminants,
such
as
heavy
metals,
microplastics,
pesticides,
have
potential
influence
hepatic
metabolism
aggravate
MASLD/MASH
These
not
only
directly
affect
lipid
hepatocytes
but
also
other
cell
types,
immune
cells
stellate
cells,
well
gut-liver
axis.
Collectively,
these
findings
contribute
establishing
well-defined
adverse
outcome
pathway
identify
novel
therapeutic
options
diseases
associated
with
pollutants.
