
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Язык: Английский
Environment International, Год журнала: 2025, Номер 196, С. 109316 - 109316
Опубликована: Фев. 1, 2025
Although microplastics have been detected in human blood, placenta and other tissues. In this study, for the first time, we characterized presence variation of microplastic deposition patterns three skeletal tissues, namely bone, cartilage, intervertebral discs. Forty fragments were observed 24 samples from disc, ranging 25.44 to 407.39 μm diameter. The abundance disc (61.1 ± 44.2 particles/g) was higher than those bone (22.9 15.7 cartilage tissue (26.4 17.6 particles/g). average sizes discs (159.5 103.8 μm) (138.86 105.67 larger that (87.5 30.7 μm). most frequently identified polymers polypropylene (35 %), ethylene vinyl acetate copolymer (30 polystyrene (20 %). vivo experiment suggested invaded through blood circulation after 4 weeks exposure. Serum levels tumor necrosis factor-α (TNF-α), Type Ⅰ procollagen amino-terminal peptide (PINP), tartrate-resistant acid phosphatase-5b (TRACP-5b) elevated compared with control group (p < 0.05). Our study suggests invade supply, causing distinct accumulation these regions. Microplastic invasion can affect health by influencing expression inflammatory morphogenetic cytokines. These findings provide insights into investigating impact on health.
Язык: Английский
Процитировано
4Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116818 - 116818
Опубликована: Июль 30, 2024
Microplastics (MPs) have been detected in various human tissues. However, whether MPs can accumulate within tumors and how they affect the tumor immune microenvironment (TIME) therapeutic responses remains unclear. This study aimed to determine presence of their potential effects on TIME. Sixty-one samples were collected for analysis. The was qualitatively quantitatively assessed using pyrolysis-gas chromatography-mass spectrometry. 26 examined. Three types identified: polystyrene, polyvinyl chloride, polyethylene. In lung, gastric, colorectal, cervical tumors, MP detection rates 80 %, 40 50 17 % (7.1-545.9 ng/g), respectively. 70 pancreatic (18.4-427.1 ng/g) but not esophageal tumors. cancer, MP-infiltrated TIME exhibited a reduction CD8
Язык: Английский
Процитировано
13World Journal of Gastroenterology, Год журнала: 2024, Номер 30(9), С. 1011 - 1017
Опубликована: Март 5, 2024
With continuous population and economic growth in the 21
Язык: Английский
Процитировано
7Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(20), С. 28890 - 28904
Опубликована: Апрель 2, 2024
Abstract Inappropriate disposal of plastic wastes and their durability in nature cause uncontrolled accumulation land/marine ecosystems, also causing destructive effects by bioaccumulating along the food chain. Microplastics may chronic inflammation relation to permanent structures, especially through oxidative stress cytotoxic cellular damage, which could increase risk cancer development. The microplastics liver is a major concern, therefore, identification mechanisms hepatotoxic great importance. Polymethyl methacrylate (PMMA) widely used thermoplastic. It has been determined that PMMA disrupts lipid metabolism various aquatic organisms causes reproductive developmental toxicity. PMMA-induced humans have not yet clarified. In our study, toxic (in range 3–10 μm) on human were investigated using HepG2/THP-1 macrophage co-culture model, sensitive immune-mediated injury model. Cellular uptake micro-sized cells was done transmission electron microscopy. Determination its cell viability inflammatory response, stress, with gene protein expression levels play role mechanism pathways underlying investigated. results concluded inflammation, disruptions should be focus attention as important hepatotoxicity. Our points out potential adverse health, supports literature information subject.
Язык: Английский
Процитировано
7The Science of The Total Environment, Год журнала: 2024, Номер 953, С. 176153 - 176153
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
5Immunology Letters, Год журнала: 2025, Номер 272, С. 106976 - 106976
Опубликована: Фев. 1, 2025
Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.
Язык: Английский
Процитировано
0The Science of The Total Environment, Год журнала: 2025, Номер 968, С. 178882 - 178882
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
0Molecular & Cellular Toxicology, Год журнала: 2025, Номер 21(2), С. 387 - 397
Опубликована: Фев. 27, 2025
Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because primary organ for xenobiotic metabolism, impact of environmental stressors on homeostasis and MASLD has garnered significant interest over past few decades. The concept metabolism-disrupting chemicals (MDCs) been introduced to underscore importance factors homeostasis. Recent epidemiological biological studies suggest causal link between exposure MDCs prevalence progression MASLD. This review aims introduce emerging their representative toxic mechanisms. In particular, this focuses broadening understanding impacts or steatohepatitis (MASH) progression. research highlighted contaminants, such as heavy metals, microplastics, pesticides, have potential influence hepatic metabolism aggravate MASLD/MASH These not only directly affect lipid hepatocytes but also other cell types, immune cells stellate cells, well gut-liver axis. Collectively, these findings contribute establishing well-defined adverse outcome pathway identify novel therapeutic options diseases associated with pollutants.
Язык: Английский
Процитировано
0Nanomaterials, Год журнала: 2025, Номер 15(5), С. 394 - 394
Опубликована: Март 4, 2025
The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.
Язык: Английский
Процитировано
0Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 21, 2025
Introduction Pancreatic adenocarcinoma (PAAD) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that limits the efficacy of immunotherapy. Emerging evidence suggests tumor-specific metabolic reprogramming may drive disease progression and shape immune landscape in PAAD. Methods We integrated multi-omics data from TCGA, GEO, ICGC to identify key metabolism-related genes (MRGs) influence cell infiltration, progression, patient survival. Based on nine pivotal MRGs (including ANLN, PKMYT1, HMGA1), we developed validated novel metabolic-prognostic index (MPI). Functional enrichment analyses were conducted elucidate pathways associated with different MPI risk groups. In vitro experiments drug sensitivity performed confirm oncogenic role selected explore their therapeutic implications. Results The effectively stratified patients into high- low-risk High-MPI scores correlated poor overall survival, elevated mutation burden (TMB), an TME, evidenced reduced CD8⁺ T-cell infiltration increased expression checkpoints (PD-L1, TGF-β). revealed glycolysis folate biosynthesis as dominant high-MPI groups, whereas fatty acid metabolism prevailed low-MPI Experimental validation underscored ANLN promoting epithelial-mesenchymal transition (EMT) evasion via NF-κB signaling. knockdown significantly glycolytic activity, migration, evasion. Drug indicated resistance gemcitabine but afatinib patients. Although TIDE analysis predicted checkpoint inhibitor (ICI) tumors, subset showed favorable responses anti-PD-L1 therapy. Discussion These findings provide comprehensive framework for understanding how shapes PAAD’s TME affects treatment outcomes. By accurately stratifying patients, serves promising tool guide decisions, including targeted therapy selection immunotherapy prediction, ultimately offering potential more personalized management
Язык: Английский
Процитировано
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