Maternal PFOS exposure in mice induces hepatic lipid accumulation and inflammation in adult female offspring: Involvement of microbiome-gut-liver axis and autophagy

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134177 - 134177

Опубликована: Март 30, 2024

Язык: Английский

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Crop Contamination and Human Exposure to Per- and Polyfluoroalkyl Substances around a Fluorochemical Industrial Park in China

Toxics, Год журнала: 2024, Номер 12(4), С. 269 - 269

Опубликована: Апрель 4, 2024

Due to their significant environmental impact, there has been a gradual restriction of the production and utilization legacy per- polyfluoroalkyl substances (PFAS), leading continuous development adoption novel alternatives. To effectively identify potential risks from crop consumption, levels 25 PFAS, including fourteen perfluoroalkyl acids (PFAAs), two precursor nine alternatives, in agricultural soils edible parts various crops around fluoride industrial park (FIP) Changshu city, China, were measured. The concentration ΣPFAS all ranged 11.64 299.5 ng/g, with perfluorobutanoic acid (PFBA) being dominant compound, accounting for an average 71% ΣPFAS. substance, N-methylperfluoro-octanesulfonamidoacetic (N-MeFOSAA), was detected samples. Different types showed distinguishing accumulation profiles PFAS. Solanaceae leafy vegetables higher PFAS contamination, highest concentrations reaching 190.91 175.29 respectively. ΣAlternative at 15.21 ng/g. human exposure through consumption aged groups also evaluated. maximum PFOA urban toddlers reached 109.8% standard value set by European Food Safety Authority (EFSA). In addition, short-chained PFAAs alternatives may pose health via consumption.

Язык: Английский

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Mechanistic insights into adsorption-desorption of PFOA on biochars: Effects of biomass feedstock and pyrolysis temperature, and implication of desorption hysteresis

The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177668 - 177668

Опубликована: Ноя. 23, 2024

Язык: Английский

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Migration characteristics and toxic effects of perfluorooctane sulfonate and perfluorobutane sulfonate in tobacco

The Science of The Total Environment, Год журнала: 2025, Номер 961, С. 178405 - 178405

Опубликована: Янв. 1, 2025

Язык: Английский

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Destruction of perfluorooctanoic acid (PFOA) and perfluorooctadecanoic acid (PFOcDA) by incineration: Analysis of the by-products and their characteristics

Chemosphere, Год журнала: 2025, Номер 373, С. 144165 - 144165

Опубликована: Янв. 29, 2025

Язык: Английский

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Functionalized borophene with methylene blue tagging for sensitive electrochemical detection of PFOA

Materials Science and Engineering B, Год журнала: 2025, Номер 314, С. 118073 - 118073

Опубликована: Фев. 3, 2025

Язык: Английский

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PFOS and Its Substitute OBS Cause Endothelial Dysfunction to Promote Atherogenesis in ApoE^–/– Mice

Environment & Health, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Perfluorooctanesulfonate (PFOS), an emerging contaminant with widespread concern, has been associated the pathogenesis of atherosclerosis (AS). As a substitute for PFOS, sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is extensively utilized in various applications and detected human blood. However, its potential health risk AS remain unclear. In this study, we investigated comparative impacts PFOS OBS on endothelial dysfunction atherogenesis. vivo Apolipoprotein E knockout (ApoE–/–) mice were exposed to 0.4 or 4 mg/L PFOS/OBS 12 weeks. We found that dyslipidemia developed more rapidly OBS-exposed than PFOS-exposed mice. exhibited higher enrichment capacity both blood aortic tissues OBS. Remarkably, induced pronounced inflammatory response caused significant disruption barrier aorta ApoE–/– compared PFOS. vitro experiments showed OBS, at same exposure concentrations durations as (0.1–20 μmol/L, 48 h), effectively inhibited cell viability umbilical vein cells (HUVECs), levels lactate dehydrogenase (LDH) release, enhanced adhesion between HUVECs monocytes. Both activate NF-κB signaling pathway upregulate expression factors. Notably, use but not was shown disrupt junctions increase permeability by activating MAPK/ERK pathway. Our findings suggest may lead have greater impact presenting risks cardiovascular diseases.

Язык: Английский

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Holistic Assessment of Chemical and Biological Pollutants in a Mediterranean Wastewater Effluent-Dominated Stream: Interactions and Ecological Impacts

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125833 - 125833

Опубликована: Фев. 1, 2025

Язык: Английский

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PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137685 - 137685

Опубликована: Фев. 20, 2025

Язык: Английский

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Per- and polyfluoroalkyl substances (PFAS) in the cryosphere – occurrence, organismic accumulation, ecotoxicological impacts, transformation, and management strategies

Frontiers in Environmental Science, Год журнала: 2025, Номер 13

Опубликована: Апрель 8, 2025

The cryosphere faces increasing threats from anthropogenic pollutants, including per- and polyfluoroalkyl substances (PFAS), a class of synthetic chemicals produced in significant quantities released into the environment for over seven decades. PFAS are widely utilized their water- grease-resistant properties numerous industrial, household, personal care, medical products. Despite widespread applications, all or degradation transformation products environmentally persistent pose health risks to humans. detected ubiquitously, even remote regions like Arctic Antarctica, they bioaccumulate within polar trophic food chains. primary transport transmission mechanisms involve atmospheric through volatile precursors, oxidation, ocean currents, formation sea spray aerosols. Additionally, contamination surface snow, post-deposition processes sediment interactions significantly contribute transport. physical chemical properties, density, melting points (Tm), boiling (Tb), solubility, vapor pressure, electronegativity, low polarizability, stability, thermal play key roles determining environmental fate transformation. toxicity certain has raised concerns, prompting bans efforts develop safer alternatives. public awareness regulations limit production legacy PFAS, long-term impacts remain unclear. As global warming accelerates shrinkage, which releases with meltwater, cold-adapted ecosystems associated biota face unprecedented challenges uncertainties, particularly regarding accumulation non-degradable materials. This situation underscores urgent need comprehensively understand adopt effective management strategies systems. review summarizes current literature on transport, distribution, along known ecological impacts, bioremediation potential, other options cryosphere.

Язык: Английский

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