Buildings,
Год журнала:
2024,
Номер
14(11), С. 3397 - 3397
Опубликована: Окт. 25, 2024
Phthalates
are
commonly
found
in
indoor
environments.
Consequently,
children
may
be
exposed
to
phthalates
through
the
air,
potentially
causing
health
issues.
We
collected
72
air
samples
from
60
households
and
12
classrooms
Jinan,
surveyed
health-examined
children,
assessed
their
phthalate
inhalation
exposure,
analyzed
associations
between
exposure
levels
children’s
anthropometric
physiological
indicators.
Eight
were
detected
classrooms,
with
detection
frequencies
ranging
91.6%
100%.
Di-iso-butyl
(DiBP),
di-n-butyl
(DnBP),
di
(2-ethylhexyl)
(DEHP)
predominant
phthalates.
Children’s
ranged
8.90
147
ng/(kg·day),
DEHP
being
main
inhaled
phthalate.
The
non-carcinogenic
risks
of
environments
where
live
within
acceptable
limits.
has
a
low
carcinogenic
risk.
Di-n-octyl
(DnOP)
was
associated
decrease
body
mass
index
z-score,
waist
circumference,
hip
circumference.
Additionally,
negatively
waist-to-hip
ratio.
DiBP
systolic
blood
pressure
while
DnOP
diastolic
z-score.
Furthermore,
positively
fractional
exhaled
nitric
oxide
findings
this
study
suggest
that
substantially
affect
various
metrics
including
index,
pressure,
increase
risk
respiratory
tract
inflammation.
Global
textile
production,
driven
by
consumer
demand,
raises
significant
concerns
about
chemical
exposures
from
clothing
and
related
products.
This
review
synthesizes
evidence
(2019–2025)
on
hazardous
substances
in
textiles,
including
dyes,
plasticizers,
per-
polyfluoroalkyl
(PFAS),
metals,
evaluates
their
human
health
risks.
Focusing
dermal
absorption
as
the
primary
exposure
route,
risks
to
vulnerable
populations
(e.g.,
infants,
pregnant
women)
gaps
regulatory
frameworks
are
highlighted.
The
current
analysis
reveals
that
chronic
mixtures
textiles
remains
poorly
understood,
with
safety
assessments
often
neglecting
synergistic
effects.
Key
findings
include
elevated
phthalates
infant
clothing,
PFAS
water-repellent
fabrics,
carcinogenic
aromatic
amines
azo
dyes.
We
underscore
urgency
of
harmonized
global
regulations,
advanced
biomonitoring,
sustainable
alternatives
enzymatic
biodegradable
finishes).
Public
awareness
initiatives
stricter
enforcement
certifications
OEKO-TEX®,
GOTS)
critical
mitigating
Integrating
health-centric
approaches
into
sustainability
agendas
is
imperative
for
safeguarding
consumers
ecosystems.
International Journal of Environmental Health Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Апрель 15, 2025
Phthalates
in
indoor
environments
can
enter
the
human
body
through
non-dietary
exposure
routes.
Excessive
to
phthalates
children
may
cause
health
issues.
We
examined
concentrations,
oral
intake,
and
risks
for
primary-school
students
their
living
(home,
classroom,
outdoor)
Jinan.
collected
138
dust
samples
focused
on
13
common
phthalates.
were
ubiquitous
across
all
environments,
with
di(2-ethylhexyl)
phthalate
(DEHP),
di-n-butyl
(DnBP),
di-iso-butyl
(DiBP)
representing
highest
proportions.
Concentrations
varied
by
environment:
girls'
bedrooms
>
boys'
bedrooms,
rooms
rooms,
homes
classrooms
outdoors,
urban
outdoors
suburban
outdoors.
Factors
such
as
PM2.5
levels,
use
of
personal
care
products,
item
types,
fabric
types
influenced
concentrations.
Oral
data
showed
that
home
is
primary
environment,
accounting
51%-88%,
followed
classroom
outdoor
environments.
The
carcinogenic
risk
associated
DEHP
exceeded
acceptable
limits
children,
four
exhibiting
hazard
index
values
greater
than
1.
provide
significant
school
suggest
reduction
strategies
should
focus
DEHP,
DnBP,
DiBP
both
classrooms.
Global
textile
production,
driven
by
consumer
demand,
raises
significant
concerns
about
chemical
exposures
from
clothing
and
related
products.
This
review
synthesizes
evidence
(2019–2025)
on
hazardous
substances
in
textiles,
including
dyes,
plasticizers,
per-
polyfluoroalkyl
(PFAS),
metals,
identifies
categorizes
their
associated
human
health
risks.
Focusing
dermal
absorption
as
the
primary
exposure
route,
risks
to
vulnerable
populations
(e.g.,
infants,
pregnant
women)
gaps
regulatory
frameworks
are
highlighted.
The
current
analysis
reveals
that
chronic
mixtures
textiles
remains
poorly
understood,
with
safety
assessments
often
neglecting
synergistic
effects.
Key
findings
include
elevated
phthalates
infant
clothing,
PFAS
water-repellent
fabrics,
carcinogenic
aromatic
amines
azo
dyes.
We
underscore
urgency
of
harmonized
global
regulations,
advanced
biomonitoring,
sustainable
alternatives
enzymatic
biodegradable
finishes).
Public
awareness
initiatives
stricter
enforcement
certifications
OEKO-TEX®,
GOTS)
critical
mitigating
_Interdisciplinary
collaboration
among
technologists,
toxicologists,
public
experts
is
essential
develop
safer
integrate
health-centric
approaches
into
sustainability
agendas,
safeguarding
consumers,
workers,
ecosystems._
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 20, 2024
Abstract
AIM
We
investigated
the
mechanism
of
action
whereby
exposure
to
dimethyl
phthalate
(DMP),
an
environmental
pollutant,
causes
cognitive
impairment.
METHODS
Network
pharmacology
was
used
analyze
targets
and
regulatory
networks
associated
with
DMP-brain
injury-cognitive
The
intake
DMP
simulated
by
exposure,
Morris
water
maze
adopted
examine
tissue
levels
inflammatory
cytokines
were
detected.
Brain
damage
assayed
H&E
Nissl
staining,
protein
expression
identified
Western
blotting.
effects
observed
after
separate
application
siRNA-COX2
celecoxib-COX2
inhibitors.
In
in
vitro
experiment,
on
microglia
activation
investigated.
RESULTS
revealed
that
PTGS2
(COX2)
significantly
correlated
DMP,
which
could
act
through
COX2.
After
mice
showed
significant
brain
injury
impairment,
along
upregulation
cytokines.
inhibit
ameliorate
impairment
mice.
results
activate
cause
neuroinflammation.
CONCLUSION
can
induce
neuroinflammation
COX2-mediated
microglia,
resulting
COX2
is
important
target
for
action.
