This
study
explores
the
therapeutic
potential
of
ω-3
algal
oil
(rich
in
DHA)
and
ω-7
sea
buckthorn
palmitoleic
acid)
addressing
hyperlipidemia
associated
metabolic
disorders.
These
oils
regulate
lipid
metabolism
through
PPARγ-LXRα-ABCA1/ABCG1
signaling
pathway,
reducing
cholesterol
accumulation,
oxidative
stress,
inflammation.
In
high-fat
diet-induced
hyperlipidemic
mice,
supplementation
with
these
significantly
improved
profiles,
alleviated
hepatic
steatosis,
promoted
cardiovascular
health.
The
combination
fatty
acids
showed
synergistic
effects,
offering
greater
efficacy
compared
to
individual
treatments.
findings
suggest
that
could
serve
as
dietary
supplements
or
interventions
for
managing
hyperlipidemia,
non-alcoholic
liver
disease
(NAFLD),
diseases.
highlights
novel,
natural
solutions
health
improvement.
Polymers,
Год журнала:
2024,
Номер
16(19), С. 2807 - 2807
Опубликована: Окт. 3, 2024
The
extensive
use
of
polymeric
materials
has
resulted
in
significant
environmental
pollution,
prompting
the
need
for
a
deeper
understanding
their
degradation
processes
and
impacts.
This
review
provides
comprehensive
analysis
environment
impact
on
health
experimental
animals.
It
identifies
common
polymers,
delineates
pathways,
describes
resulting
products
under
different
conditions.
covers
physical,
chemical,
biological
mechanisms,
highlighting
complex
interplay
factors
influencing
these
processes.
Furthermore,
it
examines
implications
products,
using
animals
as
proxies
assessing
potential
risks
to
human
health.
By
synthesizing
current
research,
focuses
studies
related
small
organisms
(primarily
rodents
invertebrates,
supplemented
by
fish
mollusks)
explore
effects
polymer
living
underscores
urgency
developing
implementing
effective
waste
management
strategies.
These
strategies
are
crucial
mitigating
adverse
impacts
degradation,
thus
promoting
more
sustainable
interaction
between
activities
natural
environment.
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Microplastics
(MPs)
and
Di-(2-ethylhexyl)
phthalate
(DEHP)
as
emerging
contaminants,
have
caused
increasing
concern
due
to
their
co-exposure
risks
toxicities
humans.
Lactic
acid
bacteria
been
demonstrated
play
a
significant
role
in
the
mitigation
of
organismal
damage.
Probiotic
intervention
is
widely
recognized
safe
healthy
therapeutic
strategy
for
targeting
organic
This
study
explored
effectiveness
underlining
mechanism
an
excellent
probiotic
property
Lactiplantibacillus
plantarum
P101
(L.
P101)
combined
hepatotoxicity
MPs
DEHP.
In
this
study,
mice
were
exposed
DEHP
via
free
drinking
water,
followed
by
with
L.
P101.
Results
showed
that
severe
oxidative
stress
inflammation
liver
intestines,
which
was
reversed
after
intervention.
Moreover,
reshaped
structure
gut
microbiota
alleviated
damage
exposure.
Together,
we
found
effectively
mitigated
toxic
effects
on
system
DEHP,
offering
promising
reducing
toxicity
these
substances.
Toxics,
Год журнала:
2025,
Номер
13(1), С. 44 - 44
Опубликована: Янв. 8, 2025
Bisphenol
S
(BPS)
is
a
typical
endocrine
disruptor
associated
with
obesity.
To
observe
BPS
effects
on
lipid
metabolism
in
HepG2
and
SK-Hep-1
human
HCC
cells,
CCK-8
assay
was
used
to
assess
cell
proliferation
response
BPS,
the
optimal
concentration
of
selected.
Biochemical
indices
such
as
triglyceride
(TG)
total
cholesterol
(T-CHO),
oxidative
stress
malondialdehyde
(MDA)
catalase
(CAT)
were
measured.
ROS
MDA
levels
significantly
increased
after
treatment
for
24
h
48
(p
<
0.05),
indicating
an
response.
Alanine
aminotransferase
(ALT),
T-CHO,
low-density
lipoprotein
(LDL-C)
also
or
treatments
0.05).
RT-PCR
Western
blot
analyses
detected
mRNA
protein
expression
peroxisome
proliferator-activated
receptor
α
(PPARα)
sterol
regulatory
element-binding
1c
(SREBP1C).
The
results
indicated
that
could
inhibit
PPARα
carnitine
palmitoyl
transferase
1B
(CPT1B),
reduce
metabolism,
promote
SREBP1C
fatty
acid
synthase
(FASN),
increase
synthesis.
Increased
droplets
observed
using
morphological
Oil
Red
O
staining.
Our
study
demonstrates
may
cause
accumulation
by
increasing
perturbing
cellular
metabolism.
