Exploring DiPP (Diisopentyl Phthalate) Neurotoxicity and the Detoxification Process in Zebrafish Larvae – A Silent Contaminant?
Environmental Research,
Год журнала:
2025,
Номер
unknown, С. 120825 - 120825
Опубликована: Янв. 1, 2025
Язык: Английский
Glyphosate and its formulated product Roundup Transorb R® affect locomotor activity and reproductive and developmental parameters in Jenynsia lineata fish: an intergenerational study
Chemosphere,
Год журнала:
2024,
Номер
362, С. 142541 - 142541
Опубликована: Июнь 6, 2024
Язык: Английский
Multiparameter analysis of Diuron and its metabolites (DCA and DCPMU) in different stages of zebrafish (Danio rerio) development
Frontiers in Water,
Год журнала:
2024,
Номер
6
Опубликована: Сен. 24, 2024
Introduction
Diuron
(3-(3,4-dichlorophenyl)-1,1-dimethylurea)
is
a
prominent
herbicide
in
Brazilian
agriculture,
particularly
sugarcane
farming.
This
persists
the
environment
and
transformed
into
potentially
toxic
metabolites,
such
as
3,4-dichloroaniline
(DCA)
3-(3,4-dichlorophenyl)-1-methylurea
(DCPMU),
raising
concerns
that
encompass
environmental
contamination
One
Health,
which
unites
human
health.
Zebrafish
are
an
appropriate
experimental
model
to
evaluate
toxicity:
they
metabolically
genetically
resemble
humans
can
be
applied
ecotoxicology.
Methods
In
this
study,
we
have
employed
multiparameter
evaluation
characterize
toxicity
of
environmentally
relevant
concentrations
(0.5–100
μM)
Diuron,
DCA,
or
DCPMU
Brazil,
developing
country.
early
stages
zebrafish
development,
performed
fish
embryo
test
according
guidelines
established
OECD
Protocol
No.
236,
extended
144
h
post
fertilization
(hpf).
We
also
investigated
oxygen
consumption
rate
embryos
at
24
hpf,
evaluated
acetylcholinesterase
(AChE)
enzymatic
activity
larvae
96
used
Comet
Assay
assess
DNA
fragmentation
hpf.
subjected
adult
acute
exposure
for
accordance
with
protocol
no.
203
Acute
Toxicity
Test
Fish.
Following
exposure,
analyzed
mutagenicity
by
using
micronucleus
test,
was
complemented
quantification
nuclear
anomalies
(NA)
erythrocytes
further
confirmed
histopathological
investigations.
Results
discussion
Exposure
any
tested
damaged
DNA,
NA
became
significant
beyond
10
μM
Diuron.
At
μM,
DCA
altered
AChE
activity,
suggesting
neuromuscular
toxicity.
Between
0.5
5
genotoxic,
5–10
induced
pleomorphism.
all
concentrations,
emerged
between
1
DCPMU.
Adult
exposed
did
not
exhibit
alterations.
Erythrocyte
morphology
analysis
reveal
mutagenicity.
Although
observed
non-mutagenic
genotoxicity,
chromosomal
instability
concern.
The
findings
study
contribute
our
understanding
how
its
metabolites
affect
highlights
need
multiparametric
assessment
elucidate
herbicides
their
impact
endeavor
informs
regulatory
measures
safely
similar
reveals
substantial
implications
nations
grappling
escalating
water
due
pesticide
use.
Язык: Английский
Developmental Toxicity of Glyphosate, its formulations and AMPA in Non-Target Organisms: Insights from Zebrafish Embryos and Larvae
Journal of Hazardous Materials Advances,
Год журнала:
2024,
Номер
unknown, С. 100516 - 100516
Опубликована: Окт. 1, 2024
Язык: Английский
A review of the influence of pH on toxicity testing of acidic environmental chemical pollutants in aquatic systems using zebrafish (Danio rerio) and glyphosate toxicity as a case study
Vasisht Varsh Sridhar,
Lucas W. Turner,
Leeah S. Reidenbach
и другие.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
289, С. 117506 - 117506
Опубликована: Дек. 12, 2024
Язык: Английский