The Individual and Combined Effects of Prenatal Micronutrient Supplementations on Neurobehavioral Developmental Disorders in Preschool Children
Children,
Год журнала:
2025,
Номер
12(5), С. 602 - 602
Опубликована: Май 5, 2025
Background:
Neurobehavioral
developmental
disorders
significantly
affect
children’s
future
well-being
and
contribute
to
the
global
disease
burden.
While
prenatal
micronutrient
supplementation
is
crucial
for
fetal
neural
development,
their
individual
combined
effects
on
subsequent
neurobehavioral
outcomes
in
childhood
remain
poorly
understood.
This
study
aimed
examine
of
preschool
children,
explore
across
specific
domains.
Methods:
15,636
mother-child
dyads
were
recruited
from
2022
survey
Shenzhen,
China.
Mothers
provided
information
calcium,
folic
acid,
iron,
multivitamins.
Five
domains
functioning
assessed
using
Ages
Stages
Questionnaire-Third
Edition
(communication,
gross
motor,
fine
problem-solving,
personal-social
status).
Logistic
regression
models
used
estimate
effect
supplementations
NDDs
crude,
adjusted,
full-inclusion
models.
Combined
by
multiplicative
additive
interactions
calculated
crossover
analysis.
Results:
11.7%
children
identified
as
at
risk
disorders,
with
highest
prevalence
motor
domain.
Prenatal
multivitamin
showed
a
protective
against
(OR
=
0.73,
95%
CI
0.66–0.81).
Interaction
analysis
revealed
that
combination
iron
multivitamins
further
enhanced
this
protection,
both
(IOR
1.26,
1.02–1.57)
(RERI
0.18,
0.02–0.35).
The
problem-solving
domain
consistently
greatest
benefit
these
micronutrients
individually
combination.
Conclusions:
reduces
especially
when
supplementation.
These
findings
highlight
potential
benefits
co-supplementation
strategies
improve
offspring.
Further
studies
are
recommended
confirm
underlying
mechanisms.
Язык: Английский
The effects of early childhood probiotic intake on the association between prenatal micronutrient supplementation and neurobehavioral development in preschool children: a four-way decomposition analysis
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Май 21, 2025
Neurobehavioral
developmental
disorder
(NDD)
significantly
impact
children's
long-term
wellbeing
and
contribute
to
global
disease
burden.
While
prenatal
micronutrient
supplementation
has
shown
promise
in
improving
fetal
neurodevelopment,
its
association
with
offspring's
neurobehavioral
outcomes
remains
controversial,
the
potential
effect
of
early
childhood
probiotic
intake
on
this
is
still
underexplored.
This
study
aimed
evaluate
between
development
preschool
children,
explore
quantify
association.
We
included
15,636
mother-child
dyads
Shenzhen,
China,
2022.
Mothers
provided
information
(calcium,
folic
acid,
iron,
multivitamins)
through
a
structured
questionnaire.
was
assessed
using
Ages
Stages
Questionnaire
(ASQ-3).
Logistic
regression
used
examine
NDD
across
crude,
adjusted,
full-inclusion
models.
The
evaluated
four-way
decomposition
analysis
quantified
counterfactual
attribution
under
three
scenarios.
Among
participants,
11.7%
were
identified
NDD.
Prenatal
multivitamin
associated
reduced
risk
(OR
=
0.73,
95%
CI
0.66-0.81).
Early
an
enhanced
protective
(Total
EOR
-0.33,
-0.54
-0.12),
48%
attributable
interactions.
could
prevent
additional
73
cases
(a
59%
increase),
particularly
benefiting
gross
motor,
fine
motor
personal-social
domains.
against
enhancement
effect.
These
findings
underscore
early-life
dietary
supplements
for
prevention.
Further
studies
are
recommended
confirm
these
effects
underlying
mechanisms.
Язык: Английский
Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011–2014
BMC Public Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 16, 2024
Abstract
Background
The
consequences
of
trace
element
exposure
on
cognitive
function
in
elderly
adults
have
been
recognized
as
primarily
attributed
to
the
inflammatory
response.
It
is
noteworthy
that
diet
can
either
exacerbate
or
reduce
Despite
this,
there
limited
studies
about
effects
relationship
between
and
function.
Methods
A
cross-sectional
study
utilized
data
from
2011–2014
NHANES
survey
explore
association
adults.
enrolled
1726
participants,
generalized
linear
regression
model
(GLM),
Bayesian
kernel
machine
(BKMR),
weighted
quantile
sum
(WQS),
g-computation
analysis
(Qg-comp)
were
conducted
assess
impact
five
elements
(lead,
cadmium,
mercury,
manganese,
selenium)
blood
under
anti-inflammatory
pro-inflammatory
diet.
Results
GLM
showed
a
positive
correlation
selenium
(Se)
both
instant
recall
test
(IRT)
digit
symbol
substitution
(DSST)
(β
=
2.06,
95%
CI:
0.70
~
3.41;
β
6.41,
2.35
10.46,
respectively).
In
contrast,
cadmium
(Cd)
was
negatively
associated
with
DSST
-1.17,
-2.13~
-0.22),
lead
(Pb)
IRT
-0.47,
-0.82~
-0.11).
For
animal
fluency
(AFT),
highest
quartile
manganese
(Mn)
lowest
-0.72,
-1.34~-0.10),
while
mercury
(Hg)
no
significant
associations
tests.
Subgroup
revealed
Cd
Se
Furthermore,
BKMR
an
inverted
U-shaped
curve
negative
mixtures
linearly
trend
Among
them,
emphasized
most
potent
risk
factor,
vital
protective
factor
for
WQS
Qg-comp
analysis.
Conclusions
suggests
high-quality
might
alleviate
adverse
DSST.
High
levels
also
better
scores
These
findings
provide
valuable
insights
into
connection
diet,
exposure,
Язык: Английский