Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011–2014 DOI Creative Commons
Chunlan Tang,

Min Shen,

Hang Hong

и другие.

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 16, 2024

Abstract Background The consequences of trace element exposure on cognitive function in elderly adults have been recognized as primarily attributed to the inflammatory response. It is noteworthy that diet can either exacerbate or reduce Despite this, there limited studies about effects relationship between and function. Methods A cross-sectional study utilized data from 2011–2014 NHANES survey explore association adults. enrolled 1726 participants, generalized linear regression model (GLM), Bayesian kernel machine (BKMR), weighted quantile sum (WQS), g-computation analysis (Qg-comp) were conducted assess impact five elements (lead, cadmium, mercury, manganese, selenium) blood under anti-inflammatory pro-inflammatory diet. Results GLM showed a positive correlation selenium (Se) both instant recall test (IRT) digit symbol substitution (DSST) (β = 2.06, 95% CI: 0.70 ~ 3.41; β 6.41, 2.35 10.46, respectively). In contrast, cadmium (Cd) was negatively associated with DSST -1.17, -2.13~ -0.22), lead (Pb) IRT -0.47, -0.82~ -0.11). For animal fluency (AFT), highest quartile manganese (Mn) lowest -0.72, -1.34~-0.10), while mercury (Hg) no significant associations tests. Subgroup revealed Cd Se Furthermore, BKMR an inverted U-shaped curve negative mixtures linearly trend Among them, emphasized most potent risk factor, vital protective factor for WQS Qg-comp analysis. Conclusions suggests high-quality might alleviate adverse DSST. High levels also better scores These findings provide valuable insights into connection diet, exposure,

Язык: Английский

The Individual and Combined Effects of Prenatal Micronutrient Supplementations on Neurobehavioral Developmental Disorders in Preschool Children DOI Creative Commons
Liwen Ding, Esben Strodl, Maolin Zhang

и другие.

Children, Год журнала: 2025, Номер 12(5), С. 602 - 602

Опубликована: Май 5, 2025

Background: Neurobehavioral developmental disorders significantly affect children’s future well-being and contribute to the global disease burden. While prenatal micronutrient supplementation is crucial for fetal neural development, their individual combined effects on subsequent neurobehavioral outcomes in childhood remain poorly understood. This study aimed examine of preschool children, explore across specific domains. Methods: 15,636 mother-child dyads were recruited from 2022 survey Shenzhen, China. Mothers provided information calcium, folic acid, iron, multivitamins. Five domains functioning assessed using Ages Stages Questionnaire-Third Edition (communication, gross motor, fine problem-solving, personal-social status). Logistic regression models used estimate effect supplementations NDDs crude, adjusted, full-inclusion models. Combined by multiplicative additive interactions calculated crossover analysis. Results: 11.7% children identified as at risk disorders, with highest prevalence motor domain. Prenatal multivitamin showed a protective against (OR = 0.73, 95% CI 0.66–0.81). Interaction analysis revealed that combination iron multivitamins further enhanced this protection, both (IOR 1.26, 1.02–1.57) (RERI 0.18, 0.02–0.35). The problem-solving domain consistently greatest benefit these micronutrients individually combination. Conclusions: reduces especially when supplementation. These findings highlight potential benefits co-supplementation strategies improve offspring. Further studies are recommended confirm underlying mechanisms.

Язык: Английский

Процитировано

0

The effects of early childhood probiotic intake on the association between prenatal micronutrient supplementation and neurobehavioral development in preschool children: a four-way decomposition analysis DOI Creative Commons
Liwen Ding, Maolin Zhang, Esben Strodl

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Май 21, 2025

Neurobehavioral developmental disorder (NDD) significantly impact children's long-term wellbeing and contribute to global disease burden. While prenatal micronutrient supplementation has shown promise in improving fetal neurodevelopment, its association with offspring's neurobehavioral outcomes remains controversial, the potential effect of early childhood probiotic intake on this is still underexplored. This study aimed evaluate between development preschool children, explore quantify association. We included 15,636 mother-child dyads Shenzhen, China, 2022. Mothers provided information (calcium, folic acid, iron, multivitamins) through a structured questionnaire. was assessed using Ages Stages Questionnaire (ASQ-3). Logistic regression used examine NDD across crude, adjusted, full-inclusion models. The evaluated four-way decomposition analysis quantified counterfactual attribution under three scenarios. Among participants, 11.7% were identified NDD. Prenatal multivitamin associated reduced risk (OR = 0.73, 95% CI 0.66-0.81). Early an enhanced protective (Total EOR -0.33, -0.54 -0.12), 48% attributable interactions. could prevent additional 73 cases (a 59% increase), particularly benefiting gross motor, fine motor personal-social domains. against enhancement effect. These findings underscore early-life dietary supplements for prevention. Further studies are recommended confirm these effects underlying mechanisms.

Язык: Английский

Процитировано

0

Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011–2014 DOI Creative Commons
Chunlan Tang,

Min Shen,

Hang Hong

и другие.

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 16, 2024

Abstract Background The consequences of trace element exposure on cognitive function in elderly adults have been recognized as primarily attributed to the inflammatory response. It is noteworthy that diet can either exacerbate or reduce Despite this, there limited studies about effects relationship between and function. Methods A cross-sectional study utilized data from 2011–2014 NHANES survey explore association adults. enrolled 1726 participants, generalized linear regression model (GLM), Bayesian kernel machine (BKMR), weighted quantile sum (WQS), g-computation analysis (Qg-comp) were conducted assess impact five elements (lead, cadmium, mercury, manganese, selenium) blood under anti-inflammatory pro-inflammatory diet. Results GLM showed a positive correlation selenium (Se) both instant recall test (IRT) digit symbol substitution (DSST) (β = 2.06, 95% CI: 0.70 ~ 3.41; β 6.41, 2.35 10.46, respectively). In contrast, cadmium (Cd) was negatively associated with DSST -1.17, -2.13~ -0.22), lead (Pb) IRT -0.47, -0.82~ -0.11). For animal fluency (AFT), highest quartile manganese (Mn) lowest -0.72, -1.34~-0.10), while mercury (Hg) no significant associations tests. Subgroup revealed Cd Se Furthermore, BKMR an inverted U-shaped curve negative mixtures linearly trend Among them, emphasized most potent risk factor, vital protective factor for WQS Qg-comp analysis. Conclusions suggests high-quality might alleviate adverse DSST. High levels also better scores These findings provide valuable insights into connection diet, exposure,

Язык: Английский

Процитировано

1