Food Insecurity Modifies the Association Between the Gut Microbiome and the Risk of Cognitive Impairment in Adults DOI Creative Commons
Shoshannah Eggers,

Zachary E. Hoggarth,

Kiran Nagdeo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Background Recent studies have shown associations between relative abundances of specific gut microbes and cognitive function; however, few explored the potential interplay microbiome food insecurity in association with risk impairment (RCI). This study investigated role as an effect modifier microbiome, including groups (microbial cliques), RCI. Methods Data came from Survey Health Wisconsin its ancillary Microbiome Study. The analytical sample (n = 360) included adult participants complete data on insecurity, RCI, 16S rRNA sequencing stool samples. A "mini-cog" memory test was implemented to assess Food assessed using a set survey-based questions. Alpha diversity individual taxa RCI were estimated linear regression. Microbial cliques associated identified interpretable machine-learning-based algorithm. All analyses stratified by level, regression models adjusted for relevant confounders. Results status weakly (b 0.06, 95%CI=[0.00, 0.12]). Gut a-diversity had inverse both secure (b=-0.08, 95%CI=[-0.15, -0.02]) insecure (b=-0.09, 95%CI=[-0.26, 0.07]).

Язык: Английский

Association between Exposure to Metals during Pregnancy, Childhood Gut Microbiome, and Risk of Intestinal Inflammation in Late Childhood DOI Creative Commons
Vishal Midya, Manasi Agrawal, Jamil M. Lane

и другие.

Environment & Health, Год журнала: 2024, Номер 2(10), С. 739 - 749

Опубликована: Авг. 8, 2024

Alterations to the gut microbiome and exposure metals during pregnancy have been suggested impact inflammatory bowel disease. Nonetheless, how prenatal eventually results in long-term effects on microbiome, leading subclinical intestinal inflammation, particularly late childhood, has not studied. It is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility inflammation. We used amalgamation machine-learning techniques with regression-based framework explore if distinct sets microbes certain patterns (metal–microbial clique signature) had higher likelihood measured based fecal calprotectin (FC) childhood. obtained samples from well-characterized longitudinal birth cohort Mexico City (n = 108), Mexico. In second third trimesters pregnancy, 11 were whole blood. Gut microbial abundances FC stool 9–11 years age. Elevated was defined as having above 100 μg/g stool. identified subgroups whom metal–microbial signatures associated (false discovery rate (FDR) < 0.05). particular, we found two significantly FC: (1) low cesium (Cs) copper (Cu) trimester relative abundance Eubacterium ventriosum (OR [95%CI]: 10.27 [3.57,29.52], FDR 0.001) (2) Cu high Roseburia inulinivorans Ruminococcus torques 7.21 [1.81,28.77], This exploratory study demonstrates that may levels denoting risk

Язык: Английский

Процитировано

5
Prenatal Metal Exposures and Childhood Gut Microbial Cliques are Associated with Elevated Fecal Calprotectin in Late Childhood DOI
Vishal Midya, Manasi Agrawal, Jamil M. Lane

и другие.

Опубликована: Янв. 1, 2024

Background: Alterations to the gut microbiome and exposure metals during pregnancy have been implicated in inflammatory bowel disease. However, their interacting effect on subclinical intestinal inflammation late childhood has not studied previously.Methods: Combining an interpretable machine-learning tool with a regression-based framework, we explored whether children specific combinations of microbes (microbial cliques) alongside groups prenatal (metal-microbial had higher likelihood inflammation, measured based fecal calprotectin (FC) childhood. We obtained samples from well-characterized longitudinal pediatric birth cohort Mexico City (n=108). Eleven were whole blood second third trimesters pregnancy. Gut microbial abundances FC stool 9-11 years age. Elevated was defined as having above 100 ug/gm stool.Findings: The median(IQR) 43.9(91.8) ug/g. identified subgroups whom cliques metal-microbial associated elevated (false discovery rate (FDR)<0.05). In particular, found two significantly FC, (1) Low Cesium (Cs) Copper (Cu) trimester low relative abundance Eubacterium ventriosum (OR[95%CI]:10.27[3.57,29.52], FDR<0.001), (2) Cu high Roseburia inulinivorans Ruminococcus torques (OR[95%CI]:7.21[1.81,28.77], FDR<0.05).Interpretation: This exploratory study demonstrates that certain may levels childhood, denoting inflammation.Funding: VM, CG, ROW are supported by National Institute Environmental Health Sciences (P30ES023515). MA is Diabetes Digestive Kidney Diseases (K23DK129762-03), General Medical (R25GM143298). SE (R00ES032884). ROW, LATO, MMTR (P30ES023515, R01ES013744). VM (U2CES030859, R35ES030435).Declaration Interest: corresponding author confirms behalf all authors there no involvements might raise question bias work reported or conclusions, implications, opinions stated. Vishal Midya, Chris Gennings, Leonid Tarassishin, Libni A. Torres-Olascoaga, Joseph Eggers, Mellissa Picker, Jill K. Gregory, Inga Peter, Martha M. Téllez-Rojo, Robert O. Wright, Shoshannah Eggers report conflicts interest. Manasi Agrawal consulted for Douglas Pharmaceuticals. Jeremiah J. Faith Scientific Advisory Board Vedanta Biosciences. Manish Arora employee equity holder Linus Biotechnology Inc., start- up company Mount Sinai System develops tools detection autism spectrum disorder related conditions. Jean-Frederic Colombel reports receiving research grants AbbVie, Janssen Pharmaceuticals Takeda; payment lectures Amgen, Allergan, Inc. Ferring Pharmaceuticals, Shire, consulting fees Arena Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corporation, Eli Lilly, Galmed Research, Glaxo Smith Kline, Geneva, Iterative Scopes, Kaleido Biosciences, Landos, Otsuka, Pfizer, Prometheus, Sanofi, Takeda, TiGenix,; hold stock options Intestinal Biotech Development.Ethical Approval: protocol PROGRESS reviewed approved Institutional Review (IRB) at Icahn School Medicine Sinai, three committees (Research, Ethics Biosafety) included IRB Public Cuernavaca, Mexico.

Язык: Английский

Процитировано

1
Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood DOI Creative Commons
Vishal Midya, Kiran Nagdeo, Jamil M. Lane

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 14, 2024

Abstract Emerging research suggests that exposures to metals during pregnancy and gut microbiome (GM) disruptions are associated with depressive disorders in childhood. Akkermansia muciniphila , a GM bacteria, has been studied for its potential antidepressant effects. However, role the influence of prenatal metal on symptoms childhood is unknown. Leveraging well-characterized pediatric longitudinal birth cohort substudy (n=112) using state-of-the-art machine-learning model, we investigated whether presence A.muciniphila 9-11-year-olds modifies associations between exposure specific group (or metal-clique) concurrent symptoms. Among children no metal-clique Zinc-Chromium-Cobalt was strongly increased depression score ( P <0.0001), whereas, this same weakly decreased score( <0.4). Our analysis provides first exploratory evidence hypothesizing as probiotic intervention attenuating effect metal-exposures-associated late

Язык: Английский

Процитировано

0
Akkermansia muciniphila attenuates the association between specific metal exposures during pregnancy and depressive symptoms in late childhood DOI Creative Commons
Vishal Midya, Kiran Nagdeo, Jamil M. Lane

и другие.

iScience, Год журнала: 2024, Номер 27(12), С. 111335 - 111335

Опубликована: Ноя. 6, 2024

Emerging research suggests that exposures to metals during pregnancy and consequent disruptions in gut microbiome (GM) are associated with depressive disorders childhood.

Язык: Английский

Процитировано

0
Food Insecurity Modifies the Association Between the Gut Microbiome and the Risk of Cognitive Impairment in Adults DOI Creative Commons
Shoshannah Eggers,

Zachary E. Hoggarth,

Kiran Nagdeo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Background Recent studies have shown associations between relative abundances of specific gut microbes and cognitive function; however, few explored the potential interplay microbiome food insecurity in association with risk impairment (RCI). This study investigated role as an effect modifier microbiome, including groups (microbial cliques), RCI. Methods Data came from Survey Health Wisconsin its ancillary Microbiome Study. The analytical sample (n = 360) included adult participants complete data on insecurity, RCI, 16S rRNA sequencing stool samples. A "mini-cog" memory test was implemented to assess Food assessed using a set survey-based questions. Alpha diversity individual taxa RCI were estimated linear regression. Microbial cliques associated identified interpretable machine-learning-based algorithm. All analyses stratified by level, regression models adjusted for relevant confounders. Results status weakly (b 0.06, 95%CI=[0.00, 0.12]). Gut a-diversity had inverse both secure (b=-0.08, 95%CI=[-0.15, -0.02]) insecure (b=-0.09, 95%CI=[-0.26, 0.07]).

Язык: Английский

Процитировано

0