Lactiplantibacillus plantarum FRT4 protects against fatty liver hemorrhage syndrome: regulating gut microbiota and FoxO/TLR-4/NF-κB signaling pathway in laying hens DOI Creative Commons

Daojie Li,

Kun Meng, Guohua Liu

и другие.

Microbiome, Год журнала: 2025, Номер 13(1)

Опубликована: Март 29, 2025

Fatty liver hemorrhage syndrome (FLHS) has become one of the major factors leading to death laying hen in caged egg production. FLHS is commonly associated with lipid peroxidation, hepatocyte injury, decreased antioxidant capacity, and inflammation. However, there are limited evidences regarding preventive effect Lactiplantibacillus plantarum on hens its mechanisms. Our previous results showed that Lp. FRT4 alleviated by regulating metabolism, but did not focus anti-inflammatory functions Therefore, this study aimed investigate mechanisms alleviating FLHS, a role activity inflammation regulation. Supplementation enhanced levels T-AOC, T-SOD, GSH-Px, while reducing TNF-α, IL-1β, IL-8, NLRP3 ovary hens. Additionally, upregulated mRNA expressions SOD1, SOD2, CAT, GPX1, downregulated pro-inflammatory IL-6, NLRP3, IL-4 IL-10. improved structure metabolic gut microbiota, regulated relative abundances dominant phyla (Bacteroidetes, Firmicute, Proteobacteria) genera (Prevotella Alistipes). it influenced key KEGG pathways, including tryptophan amino sugar nucleotide insulin signaling pathway, FoxO pathway. Spearman analysis revealed abundance microbiota at different taxonomic was closely related enzymes inflammatory factors. Furthermore, modulated FoxO/TLR-4/NF-κB pathway microbiota. Moreover, E2, FSH, VTG were significantly increased after intervention. effectively ameliorates This efficacy attributed properties, which mediated modulating function further intervening These actions enhance hepatic ovarian increase estrogen levels. Video Abstract.

Язык: Английский

Effects of starvation-refeeding on antioxidant status, metabolic function, and adaptive response in the muscle of Cyprinus carpio DOI
Wenrong Feng, Jianlin Li, Yuanfeng Xu

и другие.

Aquaculture, Год журнала: 2025, Номер unknown, С. 742372 - 742372

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

2
Grape Seed Proanthocyanidin Extract Improves Growth Performance and Protects Against Hydrogen Peroxide-Induced Oxidative Stress to the Liver and Intestine in Weaned Hyla Rabbits DOI Creative Commons

Maohua Gong,

Lei Liu, Fuchang Li

и другие.

Animals, Год журнала: 2025, Номер 15(3), С. 327 - 327

Опубликована: Янв. 24, 2025

Three experiments were conducted to investigate the effects of grape seed proanthocyanidin extract (GSPE) on growth performance weaned Hyla rabbits and explore its protective against oxidative stress in liver intestine by establishing a hydrogen peroxide (H2O2)-induced model. In Exp.1, ninety-six used evaluate dietary GSPE level performance, results showed that 400 mg/kg addition increased feed conversion ratio coefficient promoted cholesterol metabolism. Exp.2 was H2O2 concentration required establish an model, indicating model could be established intraperitoneal injection 10% at dosage 1 mL/kg body weight. Exp.3, seventy-two H2O2-induced intestine. Our findings supplementation alleviate adverse antioxidant capacity as well morphology. Therefore, improve small enhancing antioxidative rabbits.

Язык: Английский

Процитировано

1
Condition optimization, molecular mechanism and metabolic pathway of p-chloroaniline biodegradation enhanced by aniline as the co-substrate DOI

Mingjun Zhu,

Yonglin Bo,

Yufeng Sun

и другие.

Biochemical Engineering Journal, Год журнала: 2024, Номер 211, С. 109460 - 109460

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

4
Biochemical and Transcriptomic Analysis Reveals Low Temperature-Driven Oxidative Stress in Pupal Apis mellifera Neural System DOI Creative Commons
Xiangjie Zhu,

Mingjie Cao,

Chenyang Li

и другие.

Insects, Год журнала: 2025, Номер 16(3), С. 250 - 250

Опубликована: Март 1, 2025

Exposure to low temperatures during honeybee development has been shown impede brain and affect cognitive function in adult bees. On the other hand, neuronal damage due oxidative stress reported many cases. Hence, biochemical parameters related pupae were determined. The levels of GSH pupal decreased after 24 h 48 exposure temperatures; there also reduced activities SOD CAT enzymes following low-temperature treatment compared control group. Furthermore, analysis transcriptome data post-24 -48 revealed suppression glutathione metabolism peroxisome pathways brains. Additionally, expression pattern clustering KEGG enrichment showed that 10 differentially expressed genes with down-regulated trends post-low-temperature significantly enriched pathway, including PEX10, highlighting their connection function. RT-qPCR validation was conducted on 11 core identified via GSEA, all these exhibited a downregulated pattern, confirming inhibition under stress. present study exposing suppressed both pathways, resulting increased This research enhances our understanding how reacts cold illuminates neural associated capped brood development.

Язык: Английский

Процитировано

0
Lactiplantibacillus plantarum FRT4 protects against fatty liver hemorrhage syndrome: regulating gut microbiota and FoxO/TLR-4/NF-κB signaling pathway in laying hens DOI Creative Commons

Daojie Li,

Kun Meng, Guohua Liu

и другие.

Microbiome, Год журнала: 2025, Номер 13(1)

Опубликована: Март 29, 2025

Fatty liver hemorrhage syndrome (FLHS) has become one of the major factors leading to death laying hen in caged egg production. FLHS is commonly associated with lipid peroxidation, hepatocyte injury, decreased antioxidant capacity, and inflammation. However, there are limited evidences regarding preventive effect Lactiplantibacillus plantarum on hens its mechanisms. Our previous results showed that Lp. FRT4 alleviated by regulating metabolism, but did not focus anti-inflammatory functions Therefore, this study aimed investigate mechanisms alleviating FLHS, a role activity inflammation regulation. Supplementation enhanced levels T-AOC, T-SOD, GSH-Px, while reducing TNF-α, IL-1β, IL-8, NLRP3 ovary hens. Additionally, upregulated mRNA expressions SOD1, SOD2, CAT, GPX1, downregulated pro-inflammatory IL-6, NLRP3, IL-4 IL-10. improved structure metabolic gut microbiota, regulated relative abundances dominant phyla (Bacteroidetes, Firmicute, Proteobacteria) genera (Prevotella Alistipes). it influenced key KEGG pathways, including tryptophan amino sugar nucleotide insulin signaling pathway, FoxO pathway. Spearman analysis revealed abundance microbiota at different taxonomic was closely related enzymes inflammatory factors. Furthermore, modulated FoxO/TLR-4/NF-κB pathway microbiota. Moreover, E2, FSH, VTG were significantly increased after intervention. effectively ameliorates This efficacy attributed properties, which mediated modulating function further intervening These actions enhance hepatic ovarian increase estrogen levels. Video Abstract.

Язык: Английский

Процитировано

0