Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Апрель 2, 2025
Cellular
senescence,
a
stable
state
of
cell
cycle
arrest
induced
by
various
stressors
or
genomic
damage,
is
recognized
as
hallmark
cancer.
It
exerts
context-dependent
dual
role
in
cancer
initiation
and
progression,
functioning
tumor
suppressor
promoter.
The
complexity
senescence
arises
from
its
mechanistic
diversity,
potential
reversibility,
heterogeneity.
A
key
mediator
these
effects
the
senescence-associated
secretory
phenotype
(SASP),
repertoire
bioactive
molecules
that
influence
microenvironment
(TME)
remodeling,
modulate
behavior,
contribute
to
therapeutic
resistance.
Given
intricate
biology,
presents
both
challenges
opportunities
for
intervention.
Strategies
targeting
pathways,
including
senescence-inducing
therapies
senolytic
approaches,
offer
promising
avenues
treatment.
This
review
provides
comprehensive
analysis
regulatory
mechanisms
governing
cellular
tumors.
We
also
discuss
emerging
strategies
highlighting
novel
opportunities.
deeper
understanding
processes
essential
developing
precision
improving
clinical
outcomes.
Язык: Английский
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1436 - 1436
Опубликована: Июнь 27, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic,
progressive
fibrotic
lung
disease
for
which
there
lack
of
effective
pharmacological
treatments.
Hirudin,
natural
peptide
extracted
from
leeches,
has
been
used
broad
purposes.
In
this
study,
we
investigated
the
therapeutic
effects
hirudin
on
IPF
and
its
related
mechanism
action.
By
constructing
mouse
model
treating
it
with
in
vivo,
found
that
exerted
anti-fibrotic,
anti-oxidative,
anti-fibroblast
senescence
effects.
Moreover,
using
an
vitro
stress-induced
premature
primary
fibroblasts
hirudin,
observed
inhibition
fibroblast
upregulation
PGC1-alpha
Sirt3
expression.
However,
specific
silencing
or
suppressed
effect
hirudin.
Thus,
PGC1-alpha/Sirt3
pathway
mediates
potentially
serving
as
molecular
underlying
anti-fibrosis
anti-oxidative
stress
lungs.
Язык: Английский
Microplastics/nanoplastics contribute to aging and age-related diseases: mitochondrial dysfunction as a crucial role
Food and Chemical Toxicology,
Год журнала:
2025,
Номер
199, С. 115355 - 115355
Опубликована: Фев. 26, 2025
Язык: Английский
Mitochondrial malfunction-initiated Leydig cell premature senescence partially participates in 1-nitropyrene-evoked downregulation of steroidogenic synthases in testes
Jian Li,
Xin Dong,
Lan Gao
и другие.
Free Radical Biology and Medicine,
Год журнала:
2024,
Номер
225, С. 456 - 468
Опубликована: Окт. 18, 2024
Язык: Английский
Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
Journal of Holistic Integrative Pharmacy,
Год журнала:
2024,
Номер
5(3), С. 205 - 214
Опубликована: Сен. 1, 2024
Язык: Английский
SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression
Journal of drug targeting,
Год журнала:
2024,
Номер
33(3), С. 328 - 340
Опубликована: Окт. 29, 2024
Coronary
heart
disease
(CHD)
combined
with
anxiety
or
depression
is
increasingly
receiving
attention
in
the
clinical
field
of
cardiology,
and
exploring
comorbidity
pathological
mechanisms
cardiovascular
psychological
disorders
a
hot
research
topic
for
scholars
this
field.
Current
suggests
that
Silent
Information
Regulatory
Factor
1
(SIRT1)
may
serve
as
potential
biomarker
mechanism
treatment
CHD
depression.
SIRT1
considered
promising
therapeutic
target
depression,
ability
to
regulate
inflammatory
cytokine
levels,
alleviate
oxidative
stress
damage,
activate
multiple
signalling
pathways,
reduce
platelet
hyperresponsiveness,
exert
neuroprotective
cardioprotective
effects.
In
comprehensive
review,
we
deeply
studied
structure,
function,
SIRT1,
discussed
its
protective
effects
nervous
system.
The
latest
progress
SIRT1's
role
was
emphasised,
including
specific
regulating
response,
alleviating
stress,
mediating
various
pathways.
addition,
article
also
summarises
patients
Язык: Английский