Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

Chemosphere, Год журнала: 2024, Номер 361, С. 142499 - 142499

Опубликована: Май 31, 2024

Язык: Английский

---

Hepatic toxicity prediction of bisphenol analogs by machine learning strategy

The Science of The Total Environment, Год журнала: 2024, Номер 934, С. 173420 - 173420

Опубликована: Май 21, 2024

Язык: Английский

---

Long-Term Exposure to Tire-Derived 6-PPD Quinone Causes Neurotoxicity and Neuroinflammation via Inhibition of HTR2A in C57BL/6 Mice

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), a novel contaminant derived from tire wear, has raised concerns due to its potential neurotoxicity, yet long-term effects on mammalian neurological health remain poorly understood. This study investigates the neurotoxic and neuroinflammatory impacts of prolonged 6-PPDQ exposure using male C57BL/6 mice. Behavioral assessments revealed significant cognitive deficits, while biochemical analyses demonstrated increased levels reactive oxygen species, apoptosis, blood-brain barrier (BBB) disruption. Elevated pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) activation microglial cells were observed, indicating robust response. Network pharmacology molecular docking identified serotonin receptor HTR2A as key target through which mediates toxic effects. Activation by agonist DOI (2,5-dimethoxy-4-iodoamphetamine) mitigated these effects, suggesting therapeutic strategy. These findings provide first evidence 6-PPDQ-induced neurotoxicity in mammals, underscoring need for preventive measures protect health.

Язык: Английский

---

Identification of cell-surface receptors associated with 6-PPD quinone-induced reproductive toxicity in Caenorhabditis elegans after long-term and low-dose exposure: A primordial response including sword effect and shield effect

Journal of Hazardous Materials, Год журнала: 2025, Номер 490, С. 137821 - 137821

Опубликована: Март 3, 2025

Язык: Английский

---

Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Niuhuang Jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119721 - 119721

Опубликована: Апрель 1, 2025

Язык: Английский

---

Chlorantraniliprole-induced oxidative stress, DNA damage, and apoptosis in Caenorhabditis elegans: Mechanistic insights and ecological risk implications

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 296, С. 118164 - 118164

Опубликована: Апрель 14, 2025

Язык: Английский

---

Exploring the Mechanisms of Neurotoxic effects from Combined Exposure to Polystyrene and Microcystin-LR in Caenorhabditis elegans

Aquatic Toxicology, Год журнала: 2025, Номер 284, С. 107403 - 107403

Опубликована: Май 7, 2025

Язык: Английский

---

Transgenerational intestinal toxicity of 6-PPD quinone in causing ROS production, enhancement in intestinal permeability and suppression in innate immunity in C. elegans

Environmental Pollution, Год журнала: 2024, Номер 363, С. 125208 - 125208

Опубликована: Окт. 30, 2024

Язык: Английский

---

Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans

Chemosphere, Год журнала: 2024, Номер 364, С. 143303 - 143303

Опубликована: Сен. 1, 2024

Язык: Английский

---