Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7420 - 7420

Опубликована: Июль 6, 2024

In recent years, the worldwide epidemic of metabolic diseases, namely obesity, syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, ones able disrupt various pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as pancreas. Among their deleterious effects, induce mitochondrial dysfunction oxidative stress, which are also major pathophysiological mechanisms underlying diseases. this narrative review, we delve into current literature EDC toxicity effects pancreatic tissues terms impaired function redox homeostasis.

Язык: Английский

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The impact of air pollution on neurodegenerative diseases: a narrative review of current evidence

The Egyptian Journal of Internal Medicine, Год журнала: 2025, Номер 37(1)

Опубликована: Янв. 24, 2025

Abstract This narrative review explores the relationship between air pollution and neurodegenerative diseases (NDs). Historically, has been linked primarily to respiratory cardiovascular issues, but recent evidence suggests that it may also impact neurological health. With global increase in diseases, understanding environmental risk factors become crucial. The synthesizes findings from studies, highlighting potential role of pollutants—particularly fine particulate matter (PM2.5), ozone, nitrogen dioxide (NO2), heavy metals—in onset progression NDs. Key mechanisms under investigation include brain inflammation microglial activation, which are believed contribute processes. Animal human studies have shown correlations exposure increased cognitive decline disorders. Research indicates exacerbate neuroinflammation cause white abnormalities, disrupt neural communication function. Additionally, emerging like residential greenness climate action could mitigate some these adverse effects. Despite advancements, significant knowledge gaps remain, particularly regarding long-term chronic specific molecular pathways involved. shows need for further research clarify develop targeted interventions. Addressing pollution’s on requires comprehensive public health strategies, including stricter regulations awareness, alongside continued into preventive therapeutic measures.

Язык: Английский

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Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 290, С. 117587 - 117587

Опубликована: Янв. 1, 2025

Chlorpyrifos (CPF) is a broad-spectrum organophosphate chloride (OP) insecticide widely used in domestic use and open field. However, there currently no relevant research revealing the toxic effects of CPF exposure on skin, then it necessary to comprehensively understand mechanisms. The results showed that skin tissue structure function mice were significantly disrupted after exposure. Furthermore, PPI network analysis molecular docking experiments pinpointed core targets such as Bcl2, EGFR, Caspase-3, TNF-α, IL-1β, VEGF. Additionally, through KEGG analysis, VEGF apoptosis signaling pathways identified pivotal implicated CPF-induced toxicity. These subsequently confirmed animal experimentation. In conclusion, our study suggests primarily induces damage by disrupting function, mediated proliferation processes cells, alongside aberrant angiogenesis heightened inflammatory response. insights are expected advance development preventive therapeutic strategies aimed at mitigating adverse skin.

Язык: Английский

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Assessment of Pesticides Concentration in South American Wines by Liquid Chromatography-Tandem Mass Spectrometry

Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107225 - 107225

Опубликована: Янв. 1, 2025

Язык: Английский

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Microbial degradation of contaminants of emerging concern: metabolic, genetic and omics insights for enhanced bioremediation

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Сен. 19, 2024

The perpetual release of natural/synthetic pollutants into the environment poses major risks to ecological balance and human health. Amongst these, contaminants emerging concern (CECs) are characterized by their recent introduction/detection in various niches, thereby causing significant hazards necessitating removal. Pharmaceuticals, plasticizers, cyanotoxins pesticides groups CECs that highly toxic found occur compartments biosphere. sources these compounds can be multipartite including industrial discharge, improper disposal, excretion unmetabolized residues, eutrophication etc ., while fate persistence determined factors such as physico-chemical properties, environmental conditions, biodegradability hydrological factors. resultant exposure microbiota has imposed a selection pressure resulted evolution metabolic pathways for biotransformation and/or utilization sole source carbon energy. Such microbial degradation phenotype exploited clean-up from environment, offering cost-effective eco-friendly alternative abiotic methods removal, mitigating toxicity. However, efficient bioprocess development bioremediation strategies requires extensive understanding individual components pathway gene clusters, proteins/enzymes, metabolites associated regulatory mechanisms. “Omics” “Meta-omics” techniques aid providing crucial insights complex interactions functions well community, enabling more effective targeted bioremediation. Aside natural isolates, engineering approaches employ application genetic enhance diversity rates. integration omics data will further developing systemic-level strategies, optimising process. This review describes bacterial catabolic pathways, genetics, four CECs: pharmaceuticals, cyanotoxins, pesticides.

Язык: Английский

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Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota

Molecular Nutrition & Food Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Scope Previous study has demonstrated the chemical structure of chondroitin sulfate (CHS) from Halaelurus burgeri skin and its effects on insulin resistance. However, precise impact this phenomenon endoplasmic reticulum (ER) stress inflammation, which contribute to resistance, remains unclear. This is investigate CHS ER stress, inflammatory response signaling, gut microbiota in high‐fat diet (HFD)‐fed mice. Methods results HFD‐fed C57BL/6J mice receive dietary gavage intervention for 18 weeks. Blood, liver tissue, feces are harvested further investigation. Results show that inhibits accompanied by lowered blood glucose, nitric oxide (NO), reactive oxygen (ROS), free fatty acids (FFA) levels, increases hepatic glycogen accumulation. Moreover, inflammation improved treatment via inactivation Toll‐like receptor 4 (TLR4) signaling downstream c‐jun N‐terminal kinase (JNK) nuclear factor kappa B (NFκB) pathways. Additionally, regulates microbiota, particularly decline Firmicutes Bacteroidetes ratio. also lowers fecal lipopolysaccharide elevates several short chain acids. Conclusion These findings suggest H. may be an alternative functional food supplement anti‐ER anti‐inflammtion, regulation microbiota.

Язык: Английский

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p38 MAPK determines the sensitivity of the aquatic keystone species Moina macrocopa to toxic Microcystis: Insights into potential biomarker applications

Environmental Pollution, Год журнала: 2024, Номер 366, С. 125458 - 125458

Опубликована: Дек. 6, 2024

Язык: Английский

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