Forever chemicals don't make hero mutant ninja turtles: Elevated PFAS levels linked to unusual scute development in newly emerged freshwater turtle hatchlings (Emydura macquarii macquarii) and a reduction in turtle populations DOI Creative Commons
David J. Beale,

Duncan J. Limpus,

Georgia M. Sinclair

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 956, С. 176313 - 176313

Опубликована: Ноя. 12, 2024

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants known to pose significant risks human wildlife health. Freshwater turtles (Emydura macquarii macquarii), as long-lived species inhabiting aquatic ecosystems, particularly vulnerable PFAS bioaccumulation. This study investigated the multifaceted impact of contamination on these turtles, focusing metabolic disruptions, reproductive success, hatchling health, population impacts. Comprehensive analyses, including proteomics, lipidomics, metabolomics, histopathology, were conducted from PFAS-impacted, control, reference sites. The findings reveal disruptions in PFAS-exposed with alterations amino acid lipid metabolism, energy production, oxidative stress responses. Proteomic analysis identified several health biomarkers indicative early disease progression. Despite high levels tissues organs, no gross or histopathological phenotypical abnormalities directly linked exposure. Gravid females contaminated sites exhibited altered egg composition, magnesium calcium ratios, potentially affecting eggshell strength. Biochemical profiles albumin yolk indicated differences metabolites lipids between sites, suggesting potential impacts embryo development. Hatchling deformities notably higher increased frequency terms types at PFAS-impacted common defects abnormal intergular scale shapes marginal counts. Furthermore, demographic profile turtle showed a lack juvenile indicating reduced recruitment long-term declines. indicates field-based demonstration an Adverse Outcome Pathway, elevated biochemical perturbations within animals, finally effects. These underscore urgent need for regulatory measures address its detrimental effects wildlife.

Язык: Английский

Bioaccumulation of perfluorooctane sulfonic acid (PFOS) and oxidative stress in snapping turtles in New York, USA DOI

Katherine Neilsen,

Eric Paul,

Brigit Humphreys

и другие.

Environmental Science and Pollution Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

1
Ecosurveillance reveals subtle metabolic effects on the non-native cane toad (Rhinella marina) from low levels of accumulated environmental per- and polyfluoroalkyl substances DOI Creative Commons
Damian C. Lettoof, Marina Suzuki, Sandra Nilsson

и другие.

Environmental Pollution, Год журнала: 2025, Номер 372, С. 125968 - 125968

Опубликована: Март 4, 2025

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment, bioaccumulate, may have toxic effects. This study used non-native cane toads (Rhinella marina) to examine PFAS metal accumulation impacts large terrestrial amphibians from urban peri-urban areas. We quantified 38 compounds 36 environmental legacy metal(loid)s 52 adult toad livers collected six locations around Southeast Queensland, Australia, along a known gradient. Associations among PFAS, metal(loid) concentrations, whole-organism metrics were assessed. An omics-led approach assessed biochemical responses liver, muscle, fat gonad/egg tissues associated with these concentrations. Liver concentrations ranged 0.5 82.1 μg/kg ww, one male outlier at 452 ww (mean: 18 ± 21 SD excluding outlier). PFOS was most dominant (60 26 SD% of total), followed by PFDoDA (13 9 SD%). The liver statistically significant variation sex Al, As, Ca, Cu, Mn, Ni, Se, Sn, Sr V. Total had no associations metrics, body condition relative femur length showed weak interaction effect between Ni. Metabolic profiling revealed sex-specific differences linked total females showing broader metabolic perturbation. strongest signals glycerolipid metabolism, ether lipid fatty acid biosynthesis, though effects weak. levels low compared those previously recorded tertiary consumers aquatic vertebrates contaminated Despite minor metabolomic changes, overall health impact minimal. These findings contribute development tissue guideline values for wild amphibians, but further studies on higher additional amphibian species needed.

Язык: Английский

Процитировано

1
PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics DOI

DruAnne L. Maxwell,

Michael C. Petriello, J. Richard Pilsner

и другие.

Seminars in Reproductive Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants found in human tissues persist the environment, posing significant risks to reproductive health. This review examines impact of PFAS exposure on male health, with a focus sperm epigenetics. PFASs disrupt endocrine function by altering key hormones impairing motility, quality, viability. Epidemiologic animal studies highlight inconsistent yet concerning associations between semen parameters, as well altered gene expression DNA methylation patterns. Moreover, during critical windows development has been linked differential impacts versus female pubertal development, cognitive outcomes, physiology, emphasizing complexity interactions. comprehensive analysis highlights need for continued research into mechanisms which influence health potential implications The emphasizes importance understanding epigenetic behind these disruptions, particularly its role heritable changes. Investigating modifications driven is crucial elucidating chemicals Future should changes both immediate fertility outcomes transgenerational risks.

Язык: Английский

Процитировано

0
Epidemiological perspectives on emerging contaminants and gout or hyperuricemia DOI Creative Commons

Weiwen Fu,

Yangyi Guang,

Zixing Zhang

и другие.

Emerging contaminants, Год журнала: 2025, Номер unknown, С. 100485 - 100485

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Assessment of PFDA toxicity on RTgill-W1 Cell Line via metabolomics and lipidomics approaches DOI Creative Commons
Thao V. Nguyen, Anupama Kumar, Maryam Taraji

и другие.

Aquatic Toxicology, Год журнала: 2025, Номер 284, С. 107395 - 107395

Опубликована: Май 4, 2025

Язык: Английский

Процитировано

0
Pondering Ponds: Exploring Correlations Between Cloacal Microbiota and Blood Metabolome in Freshwater Turtles DOI Creative Commons
T. Franciscus Scheelings, Saritha Kodikara, David J. Beale

и другие.

Microbial Ecology, Год журнала: 2025, Номер 88(1)

Опубликована: Май 23, 2025

Язык: Английский

Процитировано

0
Forever chemicals don't make hero mutant ninja turtles: Elevated PFAS levels linked to unusual scute development in newly emerged freshwater turtle hatchlings (Emydura macquarii macquarii) and a reduction in turtle populations DOI Creative Commons
David J. Beale,

Duncan J. Limpus,

Georgia M. Sinclair

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 956, С. 176313 - 176313

Опубликована: Ноя. 12, 2024

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants known to pose significant risks human wildlife health. Freshwater turtles (Emydura macquarii macquarii), as long-lived species inhabiting aquatic ecosystems, particularly vulnerable PFAS bioaccumulation. This study investigated the multifaceted impact of contamination on these turtles, focusing metabolic disruptions, reproductive success, hatchling health, population impacts. Comprehensive analyses, including proteomics, lipidomics, metabolomics, histopathology, were conducted from PFAS-impacted, control, reference sites. The findings reveal disruptions in PFAS-exposed with alterations amino acid lipid metabolism, energy production, oxidative stress responses. Proteomic analysis identified several health biomarkers indicative early disease progression. Despite high levels tissues organs, no gross or histopathological phenotypical abnormalities directly linked exposure. Gravid females contaminated sites exhibited altered egg composition, magnesium calcium ratios, potentially affecting eggshell strength. Biochemical profiles albumin yolk indicated differences metabolites lipids between sites, suggesting potential impacts embryo development. Hatchling deformities notably higher increased frequency terms types at PFAS-impacted common defects abnormal intergular scale shapes marginal counts. Furthermore, demographic profile turtle showed a lack juvenile indicating reduced recruitment long-term declines. indicates field-based demonstration an Adverse Outcome Pathway, elevated biochemical perturbations within animals, finally effects. These underscore urgent need for regulatory measures address its detrimental effects wildlife.

Язык: Английский

Процитировано

2