Bioaccumulation of perfluorooctane sulfonic acid (PFOS) and oxidative stress in snapping turtles in New York, USA
Katherine Neilsen,
Eric Paul,
Brigit Humphreys
и другие.
Environmental Science and Pollution Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Ecosurveillance reveals subtle metabolic effects on the non-native cane toad (Rhinella marina) from low levels of accumulated environmental per- and polyfluoroalkyl substances
Environmental Pollution,
Год журнала:
2025,
Номер
372, С. 125968 - 125968
Опубликована: Март 4, 2025
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
synthetic
chemicals
that
persist
in
the
environment,
bioaccumulate,
may
have
toxic
effects.
This
study
used
non-native
cane
toads
(Rhinella
marina)
to
examine
PFAS
metal
accumulation
impacts
large
terrestrial
amphibians
from
urban
peri-urban
areas.
We
quantified
38
compounds
36
environmental
legacy
metal(loid)s
52
adult
toad
livers
collected
six
locations
around
Southeast
Queensland,
Australia,
along
a
known
gradient.
Associations
among
PFAS,
metal(loid)
concentrations,
whole-organism
metrics
were
assessed.
An
omics-led
approach
assessed
biochemical
responses
liver,
muscle,
fat
gonad/egg
tissues
associated
with
these
concentrations.
Liver
concentrations
ranged
0.5
82.1
μg/kg
ww,
one
male
outlier
at
452
ww
(mean:
18
±
21
SD
excluding
outlier).
PFOS
was
most
dominant
(60
26
SD%
of
total),
followed
by
PFDoDA
(13
9
SD%).
The
liver
statistically
significant
variation
sex
Al,
As,
Ca,
Cu,
Mn,
Ni,
Se,
Sn,
Sr
V.
Total
had
no
associations
metrics,
body
condition
relative
femur
length
showed
weak
interaction
effect
between
Ni.
Metabolic
profiling
revealed
sex-specific
differences
linked
total
females
showing
broader
metabolic
perturbation.
strongest
signals
glycerolipid
metabolism,
ether
lipid
fatty
acid
biosynthesis,
though
effects
weak.
levels
low
compared
those
previously
recorded
tertiary
consumers
aquatic
vertebrates
contaminated
Despite
minor
metabolomic
changes,
overall
health
impact
minimal.
These
findings
contribute
development
tissue
guideline
values
for
wild
amphibians,
but
further
studies
on
higher
additional
amphibian
species
needed.
Язык: Английский
PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics
Seminars in Reproductive Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
persistent
environmental
contaminants
found
in
human
tissues
persist
the
environment,
posing
significant
risks
to
reproductive
health.
This
review
examines
impact
of
PFAS
exposure
on
male
health,
with
a
focus
sperm
epigenetics.
PFASs
disrupt
endocrine
function
by
altering
key
hormones
impairing
motility,
quality,
viability.
Epidemiologic
animal
studies
highlight
inconsistent
yet
concerning
associations
between
semen
parameters,
as
well
altered
gene
expression
DNA
methylation
patterns.
Moreover,
during
critical
windows
development
has
been
linked
differential
impacts
versus
female
pubertal
development,
cognitive
outcomes,
physiology,
emphasizing
complexity
interactions.
comprehensive
analysis
highlights
need
for
continued
research
into
mechanisms
which
influence
health
potential
implications
The
emphasizes
importance
understanding
epigenetic
behind
these
disruptions,
particularly
its
role
heritable
changes.
Investigating
modifications
driven
is
crucial
elucidating
chemicals
Future
should
changes
both
immediate
fertility
outcomes
transgenerational
risks.
Язык: Английский
Epidemiological perspectives on emerging contaminants and gout or hyperuricemia
Weiwen Fu,
Yangyi Guang,
Zixing Zhang
и другие.
Emerging contaminants,
Год журнала:
2025,
Номер
unknown, С. 100485 - 100485
Опубликована: Фев. 1, 2025
Язык: Английский
Assessment of PFDA toxicity on RTgill-W1 Cell Line via metabolomics and lipidomics approaches
Aquatic Toxicology,
Год журнала:
2025,
Номер
284, С. 107395 - 107395
Опубликована: Май 4, 2025
Язык: Английский
Pondering Ponds: Exploring Correlations Between Cloacal Microbiota and Blood Metabolome in Freshwater Turtles
Microbial Ecology,
Год журнала:
2025,
Номер
88(1)
Опубликована: Май 23, 2025
Язык: Английский
Forever chemicals don't make hero mutant ninja turtles: Elevated PFAS levels linked to unusual scute development in newly emerged freshwater turtle hatchlings (Emydura macquarii macquarii) and a reduction in turtle populations
The Science of The Total Environment,
Год журнала:
2024,
Номер
956, С. 176313 - 176313
Опубликована: Ноя. 12, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
persistent
environmental
contaminants
known
to
pose
significant
risks
human
wildlife
health.
Freshwater
turtles
(Emydura
macquarii
macquarii),
as
long-lived
species
inhabiting
aquatic
ecosystems,
particularly
vulnerable
PFAS
bioaccumulation.
This
study
investigated
the
multifaceted
impact
of
contamination
on
these
turtles,
focusing
metabolic
disruptions,
reproductive
success,
hatchling
health,
population
impacts.
Comprehensive
analyses,
including
proteomics,
lipidomics,
metabolomics,
histopathology,
were
conducted
from
PFAS-impacted,
control,
reference
sites.
The
findings
reveal
disruptions
in
PFAS-exposed
with
alterations
amino
acid
lipid
metabolism,
energy
production,
oxidative
stress
responses.
Proteomic
analysis
identified
several
health
biomarkers
indicative
early
disease
progression.
Despite
high
levels
tissues
organs,
no
gross
or
histopathological
phenotypical
abnormalities
directly
linked
exposure.
Gravid
females
contaminated
sites
exhibited
altered
egg
composition,
magnesium
calcium
ratios,
potentially
affecting
eggshell
strength.
Biochemical
profiles
albumin
yolk
indicated
differences
metabolites
lipids
between
sites,
suggesting
potential
impacts
embryo
development.
Hatchling
deformities
notably
higher
increased
frequency
terms
types
at
PFAS-impacted
common
defects
abnormal
intergular
scale
shapes
marginal
counts.
Furthermore,
demographic
profile
turtle
showed
a
lack
juvenile
indicating
reduced
recruitment
long-term
declines.
indicates
field-based
demonstration
an
Adverse
Outcome
Pathway,
elevated
biochemical
perturbations
within
animals,
finally
effects.
These
underscore
urgent
need
for
regulatory
measures
address
its
detrimental
effects
wildlife.
Язык: Английский