Two-layer homolog network approach for PFAS nontarget screening and retrospective data mining

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 15, 2025

Abstract The rapid increase of novel per- and polyfluoroalkyl substances (PFAS) raises concerns, while their identification remains challenging. Here, we develop a two-layer homolog network approach for PFAS nontarget screening using mass spectrometry. first layer constructs networks between homologs, with evaluation showing that it filters 94% false candidates. second builds classes to expedite the PFAS. We detected 94 in twelve waterproof products two related industrial sludges, including 36 not previously reported any sample. A local dataset is constructed retrospective analysis by re-analyzing our previous samples, revealing fifteen samples collected 2005. retrieval public database MassIVE uncovers from seven countries. reveal historic global presence PFAS, providing guidance management policy-making concerning persistent chemicals.

Язык: Английский

---

Non-target discovery and risk prediction of per- and polyfluoroalkyl substances (PFAS) and transformation products in wastewater treatment systems

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 135081 - 135081

Опубликована: Июль 2, 2024

Язык: Английский

---

Driving factor, source identification, and health risk of PFAS contamination in groundwater based on the self-organizing map

Water Research, Год журнала: 2024, Номер 267, С. 122458 - 122458

Опубликована: Сен. 15, 2024

Язык: Английский

---

Target, suspect, and non-target screening of per- and poly-fluoroalkyl substances in wastewater treatment plant effluents in South Korea using ion mobility spectrometry–mass spectrometry

The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177387 - 177387

Опубликована: Ноя. 14, 2024

Язык: Английский

---

Phytoremediation of perfluoroalkyl and polyfluoroalkyl substances (PFAS): Insights on plant uptake, omics analysis, contaminant detection and biomass disposal

The Science of The Total Environment, Год журнала: 2025, Номер 959, С. 178323 - 178323

Опубликована: Янв. 1, 2025

Язык: Английский

---

Fluorine mass flow in long-chain perfluoroalkyl carboxylic acids during thermal regeneration of granular activated carbon

Journal of Water Process Engineering, Год журнала: 2025, Номер 70, С. 106990 - 106990

Опубликована: Янв. 15, 2025

Язык: Английский

---

Toxicity assessment of wastewater using a battery of bioassays in two textile wastewater treatment plants from a large industrial park in Guangxi, Southwest China

The Science of The Total Environment, Год журнала: 2025, Номер 966, С. 178766 - 178766

Опубликована: Фев. 1, 2025

Язык: Английский

---

Identifying and prioritizing organic toxicants in treated flowback and produced water from shale gas exploitation sites using an integrative effect-directed analysis and nontarget screening method

Water Research, Год журнала: 2025, Номер unknown, С. 123311 - 123311

Опубликована: Фев. 1, 2025

Язык: Английский

---

Quantifying Footprints of Perfluorinated Compounds in China: From Production to Discharge into the Seas

ACS ES&T Water, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

---

Unraveling the Exposure Spectrum of PFAS in Fluorochemical Occupational Workers: Structural Diversity, Temporal Trends, and Risk Prioritization

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Despite extensive poly/perfluoroalkyl substance (PFAS) discovery studies in various samples, the exposure spectrum fluorochemical occupational workers remains largely unexplored. Here, serum samples from 28 at a facility were analyzed using nontarget techniques, identifying 64 PFAS classes, including 15 novel ones such as pentafluorosulfur ether-substituted perfluoroalkyl sulfonic acids, hydrogen-substituted perfluoroalkylamines, and perfluoroalkylsulfonyl protocatechualdehyde esters. Temporal trend analyses (2008–2018) revealed stable levels for most but an increase perfluorobutanoic acid (PFBA) perfluorohexanesulfonic (PFHxS), suggesting industrial shifts long-chain to short-chain homologues China since early 2010s. Commonly reported structurally modified (e.g., hydrogen/carbonyl/chlorine substitution, ether insertion, unsaturation) likely historical byproducts of legacy production rather than intentionally manufactured alternatives. A Toxicological Priority Index-based risk assessment, integrating mobility, persistence, bioaccumulation indices, identified di(perfluoroakyl sulfonyl)imides, acids/carboxylic perfluoroalkylsulfonamidoacetic acids high-risk chemicals. Overall, exhibited higher mobility lower persistence PFAS, except chlorinated variants, which showed increased potential. This study highlights critical gaps historically emitted emphasizes need large-scale monitoring assessments manage emerging PFAS.

Язык: Английский

---