
Food and Chemical Toxicology, Год журнала: 2024, Номер 193, С. 114988 - 114988
Опубликована: Сен. 7, 2024
Язык: Английский
Food and Chemical Toxicology, Год журнала: 2024, Номер 193, С. 114988 - 114988
Опубликована: Сен. 7, 2024
Язык: Английский
Journal of Hazardous Materials, Год журнала: 2024, Номер 477, С. 135345 - 135345
Опубликована: Июль 27, 2024
Язык: Английский
Процитировано
5Talanta, Год журнала: 2025, Номер 286, С. 127536 - 127536
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
0Toxics, Год журнала: 2025, Номер 13(5), С. 355 - 355
Опубликована: Апрель 29, 2025
Imidacloprid (IMI) is a widely used insecticide known for its high selectivity toward insects. Ellagic acid (EA) plant-derived polyphenolic compound recognized therapeutic potential and favorable safety profile in the treatment of various diseases. This study aimed to evaluate effects EA, formulated as novasomes (NOV), against IMI-induced thyroid dysfunction investigate underlying mechanisms. Rats were divided into four equal groups: control, EA-NOV, IMI, IMI + EA-NOV. Thyroid function was assessed by measuring free triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH) levels. tissues examined histopathological alterations, well assess oxidative/antioxidant pathway (Nrf2, SOD, TAC, MDA), inflammatory (IL-1β, TNF-α, NF-κB), apoptotic (Bcl, BAX), autophagy (PI3K/Akt/mTOR, P53, Beclin-1). Exposure resulted impaired function, upregulated gene expression PI3K/Akt/mTOR pathway, downregulated P53 expression. Additionally, immunohistochemical staining revealed Beclin-1-mediated autophagy, alongside increased apoptosis, oxidative stress, elevated levels cytokines. Conversely, EA improved ameliorated alterations enhancing autophagy-inducing pathways. alleviation stress evidenced Nrf2, which promoted synthesis activity antioxidant enzymes reduced markers. proposes use protective, naturally occurring phytoceutical dysfunction, primarily through modulation PI3K/Akt/mTOR-mediated autophagy.
Язык: Английский
Процитировано
0Journal of Hazardous Materials, Год журнала: 2025, Номер 494, С. 138695 - 138695
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0Food and Chemical Toxicology, Год журнала: 2024, Номер 193, С. 114988 - 114988
Опубликована: Сен. 7, 2024
Язык: Английский
Процитировано
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