Light-powered biodegradation of Imidacloprid by Scenedesmus sp. TXH202001: Assessing complete removal, metabolic pathways, and toxicity verification

Journal of Hazardous Materials, Год журнала: 2024, Номер 477, С. 135345 - 135345

Опубликована: Июль 27, 2024

Язык: Английский

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1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid as a novel MALDI matrix for enhanced analysis of metabolites induced by imidacloprid exposure

Talanta, Год журнала: 2025, Номер 286, С. 127536 - 127536

Опубликована: Янв. 4, 2025

Язык: Английский

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Ellagic Acid Alleviates Imidacloprid-Induced Thyroid Dysfunction via PI3K/Akt/mTOR-Mediated Autophagy

Toxics, Год журнала: 2025, Номер 13(5), С. 355 - 355

Опубликована: Апрель 29, 2025

Imidacloprid (IMI) is a widely used insecticide known for its high selectivity toward insects. Ellagic acid (EA) plant-derived polyphenolic compound recognized therapeutic potential and favorable safety profile in the treatment of various diseases. This study aimed to evaluate effects EA, formulated as novasomes (NOV), against IMI-induced thyroid dysfunction investigate underlying mechanisms. Rats were divided into four equal groups: control, EA-NOV, IMI, IMI + EA-NOV. Thyroid function was assessed by measuring free triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH) levels. tissues examined histopathological alterations, well assess oxidative/antioxidant pathway (Nrf2, SOD, TAC, MDA), inflammatory (IL-1β, TNF-α, NF-κB), apoptotic (Bcl, BAX), autophagy (PI3K/Akt/mTOR, P53, Beclin-1). Exposure resulted impaired function, upregulated gene expression PI3K/Akt/mTOR pathway, downregulated P53 expression. Additionally, immunohistochemical staining revealed Beclin-1-mediated autophagy, alongside increased apoptosis, oxidative stress, elevated levels cytokines. Conversely, EA improved ameliorated alterations enhancing autophagy-inducing pathways. alleviation stress evidenced Nrf2, which promoted synthesis activity antioxidant enzymes reduced markers. proposes use protective, naturally occurring phytoceutical dysfunction, primarily through modulation PI3K/Akt/mTOR-mediated autophagy.

Язык: Английский

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Hepatotoxicity of imidacloprid in zebrafish and the alleviating role of 10-hydroxy-2-decenoi acid: insights into oxidative stress, inflammation, and gut microbiota

Journal of Hazardous Materials, Год журнала: 2025, Номер 494, С. 138695 - 138695

Опубликована: Май 20, 2025

Язык: Английский

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Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells.

Food and Chemical Toxicology, Год журнала: 2024, Номер 193, С. 114988 - 114988

Опубликована: Сен. 7, 2024

Язык: Английский

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