Micro/nanoplastics in aquaponic systems: sources, features and and their effects on the immune system of fish

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118158 - 118158

Опубликована: Янв. 1, 2025

Язык: Английский

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Weathered polyethylene microplastics induced immunomodulation in zebrafish

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 109, С. 104478 - 104478

Опубликована: Май 25, 2024

Язык: Английский

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Micro/nano plastics in the urinary system: Pathways, mechanisms, and health risks

Environment International, Год журнала: 2024, Номер 193, С. 109109 - 109109

Опубликована: Ноя. 1, 2024

Micro/Nano plastics (MNPs) pollutants are widespread in the environment, raising significant concerns about their biosafety. Emerging studies indicate that urinary system is a primary accumulation site for MNPs, leading to severe tissue and functional damage. This review aims summarize recent research on potential hazards MNPs may pose system, highlighting mechanisms of toxicity current state knowledge. Studies have shown enter human body through drinking water, food chain, inhalation, skin contact. They penetrate bloodstream via digestive, respiratory, systems, subsequently dispersing various organs, including system. The might induce cellular oxidative stress, inflammation, apoptosis, autophagy, "intestine-kidney axis", other possible toxic mechanisms. These processes could disrupt kidney metabolic functions promote fibrosis, thereby potentially increasing risk diseases. Despite ongoing research, understanding MNPs' impact remains limited. Therefore, this provides comprehensive overview highlights key challenges, outlines future directions. It offers theoretical basis development effective protective measures policies.

Язык: Английский

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Nanoplastic-Induced Antibody Liquid-liquid Phase Separation: Insights into Potential Immunotoxic Implications

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137170 - 137170

Опубликована: Янв. 9, 2025

Язык: Английский

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Polystyrene nanoplastics exacerbate gentamicin-induced nephrotoxicity in adult rat by activating oxidative stress, inflammation and apoptosis pathways

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Язык: Английский

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Assessing toxicological risk of nanoplastics contaminants in food and feed from ingestion pathway to human diseases

F1000Research, Год журнала: 2025, Номер 14, С. 284 - 284

Опубликована: Март 12, 2025

The extensive use of plastic without an effective management system is linked to significant environmental pollution issues. The fragmentation various types waste leads the formation microplastics (MPs) and nanoplastics (NPs). NPs, measuring less than 0.1 μm pose a latent danger human food chain caused by ability traverse biological membranes MPs, potentially leading chronic diseases. widespread distribution NPs across diverse matrices their subsequent infiltration into feed chains precipitates emerging health concerns. contaminate production systems leach from packaging, infiltrating organisms at trophic levels. Seafood, processed foods, drinking water serve as vectors for absorption accumulation in tissues. pervasive contamination pathway poses substantial risks through multiple exposure routes, primarily ingestion. It can lead cytotoxicity, inflammation, genotoxicity, apoptosis. This review summarizes implications that triggers diseases such inflammatory bowel disease (IBD), kidney dysfunction, liver disease, heart problems, brain disorders, reproductive issues, cancer. Currently, no established method exists treat humans may have already ingested. Hence, it urgent mitigate harmful effects development implementation innovative, efficient, sustainable decontamination strategies. discussion highlights several advanced remediation techniques effectively reduce toxicity systems, thus mitigating associated risks.

Язык: Английский

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Effects of Polystyrene Nanoplastics on Oxidative Stress, Blood Biochemistry, and Digestive Enzyme Activity in Goldfish (Carassius auratus)

Toxics, Год журнала: 2025, Номер 13(5), С. 336 - 336

Опубликована: Апрель 24, 2025

Plastic pollution in aquatic ecosystems has become a global concern, and nanoplastics, due to their small size high penetration potential, pose significant risks organisms. This study aimed evaluate the effects of polystyrene nanoplastics (PS-NPs) on oxidative stress biomarkers, blood biochemical parameters, digestive enzyme activities Goldfish (Carassius auratus). The experiment was conducted over 21 days, exposing fish four different dietary concentrations PS-NPs (0, 1, 10, 100 mg/Kg). results showed that chronic exposure 50 nm significantly increased activity antioxidant enzymes (CAT, SOD, GPx) MDA gill, kidney, liver tissues, indicating induction stress. Furthermore, notable alterations were observed (alkaline phosphatase [ALP], alanine aminotransferase [ALT], aspartate [AST], lactate dehydrogenase [LDH]), suggesting cellular damage physiological disturbances. Additionally, PS-NP affected (amylase, lipase, protease), which may impact nutrient digestion absorption. These findings highlight can adversely affect animal health influence nutritional quality fish. Therefore, further research is necessary assess long-term ecological toxicological impacts freshwater ecosystems.

Язык: Английский

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Effects of Micro- and Nanoplastic Exposure on Macrophages: A Review of Molecular and Cellular Mechanisms

Toxicology Mechanisms and Methods, Год журнала: 2025, Номер unknown, С. 1 - 40

Опубликована: Май 5, 2025

Micro- and nanoplastics (MNPs), pervasive environmental pollutants, contaminate water, soil, air, the food chain ultimately accumulate in living organisms. Macrophages are main immune cells that gather around MNPs engulf them through process of phagocytosis. This internalization triggers M1 polarization secretion inflammatory cytokines, including IL-1, IL-18, IL-12, TNF-α, IFN-γ. Furthermore, damage mitochondria lysosomes, causing overactivation iNOS excessive production ROS. results cellular stress induce apoptosis, necroptosis, and, some cases, metosis macrophages. The also increases expression receptors, involving CD36, SR-A, LOX-1, macrophage receptor with a collagenous structure (MARCO) while decreasing ABCA-1 ABCG-1. adipose tissue macrophages trigger proinflammatory cytokine secretion, adipogenesis, lipid accumulation, insulin resistance, cytokines adipocytes. Various factors influence rate MNP by macrophages, size, charge, concentration, which affect passive diffusion. Receptor-mediated phagocytosis occurs directly via receptors like T-cell immunoglobulin mucin domain containing 4 (TIM-4) MARCO. attachment biomolecules, proteins, antibodies, opsonins, or microbes to (forming corona structures) promotes indirect receptor-mediated endocytosis, as possess TLRs FcγRIII. cause gut dysbiosis, risk factor for microenvironment polarization. Here, we review mechanisms consequences exposure, is linked autoimmunity, inflammation, cardiometabolic syndrome manifestations, atherosclerosis obesity, highlighting immunotoxicity MNPs.

Язык: Английский

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Microplastic exposure and its consequences for renal and urinary health: systematic review of in vivo studies

All Life, Год журнала: 2025, Номер 18(1)

Опубликована: Май 20, 2025

Язык: Английский

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Ion transport and metabolic regulation induced by nanoplastic toxicity in gill of Litopenaeus vannamei using proteomics

Environmental Science Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

High concentrations of nanoplastics damaged the gill tissue structure and disrupted ion homeostasis L. vannamei . Nanoplastic exposure will induce oxidative stress, affected ammonia excretion pathways even altered energy metabolism.

Язык: Английский

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