Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity DOI Creative Commons

Yajie LIU Master,

Ruilin Wang

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Abstract Background Inflammation and nutrition are crucial pathogenic mechanisms in Non-alcoholic fatty liver disease (NAFLD). The Advanced Lung Cancer Index (ALI) effectively reflects the systemic inflammation level nutritional metabolic status of patients. However, its relationship with hepatic steatosis fibrosis remains unclear. study aimed to provide novel insights into prevention by examining between ALI Controlled Attenuation Parameter (CAP) Liver Stiffness Measurement (LSM). Methods To identify connection fibrosis, this utilized descriptive analysis, multivariate linear regression, smooth curve fitting, threshold effect analysis investigate data from National Health Nutrition Examination Survey conducted 2017–2020. Results levels NAFLD (AHF) groups were considerably elevated than control group, statistical significance (NAFLD: 70.980 vs. 58.680, P < 0.001; AHF: 72.420 63.360, 0.001). Multiple regression analyses indicated significant positive associations quartiles both CAP LSM levels. There was a fitting LSM, inflection points at 88.287 98.420, respectively. Conclusion findings suggest correlation LSM. Maintaining within an appropriate range may help mitigate prevalence fibrosis.

Язык: Английский

Exposure to volatile organic compounds and suicidal ideation: Insights from a U.S. population-based study DOI Creative Commons
Huan He, Zhonghua Sun, Xin Chen

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер 379, С. 194 - 203

Опубликована: Март 11, 2025

Exposure to volatile organic compounds (VOCs) has been increasingly linked mental health disorders, but the relationship between VOCs exposure and suicidal ideation (SI) remains unclear. This study aims investigate link prevalence of SI. We analyzed data from 6966 participants in 2005-2020 National Health Nutrition Examination Survey. SI was assessed using ninth item Patient Questionnaire-9. Key urinary metabolites (mVOCs) associated with were identified elastic net regression models. Multivariate logistic restricted cubic spline used explore associations individual mVOCs To evaluate impact mixtures on SI, we applied Environmental Risk Score Weighted Quantile Sum Mediation analysis conducted determine whether inflammation oxidative stress pathways contribute observed associations. Among participants, 253 reported Across various models, only N-Acetyl-S-(2-cyanoethyl)-L-cysteine (CYMA) consistently showed a significant linear association Mixture analyses indicated positive prevalence. suggested that are unlikely be primary mechanisms linking provides first epidemiological evidence an CYMA as most critical influencing The findings suggest does not primarily involve or pathways.

Язык: Английский

Процитировано

1
Advanced lung cancer inflammation index: a key predictor of hepatic steatosis and fibrosis severity DOI Creative Commons
Yajie Liu, Ruilin Wang

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 24, 2025

The Advanced Lung Cancer Inflammation Index (ALI) reflects levels of systemic inflammation and nutrient metabolism in patients. However, connection between ALI hepatic steatosis fibrosis remains unclear. This study aims to explore the potential association ALI, Controlled Attenuation Parameter (CAP), Liver Stiffness Measurement (LSM), offering new perspectives for prevention fibrosis. Using data from National Health Nutrition Examination Survey database spanning 2017 2020, a cross-sectional 6591 participants aged 20 years older was performed assess relationship Smooth curve fitting generalized additive models were used further evaluate whether there nonlinear CAP, LSM, threshold effect analysis find inflection point. A two-part linear regression model applied estimate effects. Subgroup interaction LSM. Furthermore, verify efficacy we ROC curves compare with nutritional markers (FIB-4 index, GNRI) that have been reported be associated liver disease. MASLD 4 groups considerably elevated than control group, statistical significance (PMASLD<0.001, PAHF =0.013). Multiple analyses indicated significant positive associations its quartiles both CAP[b(95%CI) ALI=0.510(0.465,0.555), P<0.001] LSM [b(95%CI) ALI=0.011(0.009,0.013), P<0.001). There smooth CAP points at 88.287 98.420 (PLog likelihood ratio<0.001), respectively. interacts relation gender [OR(95%CI)female=0.095(0.039-0.150), OR(95%CI)male=0.174(0.118-0.230), Pfor interaction=0.044] smoking [OR(95% CI)<100cigarettes life=0.086(0.035-0.137), OR(95% CI)>100cigarettes life=0.177(0.115-0.240), interaction=0.023], patients HL CI)HL=0.014(0.008-0.019), interaction<0.001]. findings suggest correlation Maintaining within an appropriate range may help mitigate prevalence

Язык: Английский

Процитировано

0
Hexavalent Chromium and Cellular Senescence: A Comprehensive Analysis from Chromate-Exposed Occupational Population and Chromate-Inhaled Mouse Model DOI
Zhiqiang Ji, Yali Zhang, Guiping Hu

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 493, С. 138387 - 138387

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study DOI Creative Commons
X M Shi,

YiNi Wang,

Fei Yang

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity DOI Creative Commons

Yajie LIU Master,

Ruilin Wang

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Abstract Background Inflammation and nutrition are crucial pathogenic mechanisms in Non-alcoholic fatty liver disease (NAFLD). The Advanced Lung Cancer Index (ALI) effectively reflects the systemic inflammation level nutritional metabolic status of patients. However, its relationship with hepatic steatosis fibrosis remains unclear. study aimed to provide novel insights into prevention by examining between ALI Controlled Attenuation Parameter (CAP) Liver Stiffness Measurement (LSM). Methods To identify connection fibrosis, this utilized descriptive analysis, multivariate linear regression, smooth curve fitting, threshold effect analysis investigate data from National Health Nutrition Examination Survey conducted 2017–2020. Results levels NAFLD (AHF) groups were considerably elevated than control group, statistical significance (NAFLD: 70.980 vs. 58.680, P < 0.001; AHF: 72.420 63.360, 0.001). Multiple regression analyses indicated significant positive associations quartiles both CAP LSM levels. There was a fitting LSM, inflection points at 88.287 98.420, respectively. Conclusion findings suggest correlation LSM. Maintaining within an appropriate range may help mitigate prevalence fibrosis.

Язык: Английский

Процитировано

0