Vitamin E Mitigates Polystyrene-Nanoplastic-Induced Visual Dysfunction in Zebrafish Larvae

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1216 - 1216

Опубликована: Янв. 30, 2025

Vitamin E (VitE), a potent antioxidant, has demonstrated significant potential in mitigating oxidative stress and cellular damage, making it valuable agent for countering environmental toxicities, including those caused by polystyrene nanoplastics (PSNPs). This study examined the effects of PSNPs on zebrafish visual system evaluated protective role VitE. Zebrafish embryos were exposed to (0.01, 0.1, 1, 10 μg/mL) with or without 20 μM VitE co-treatment from fertilization 6 days post-fertilization (dpf). Visual function, morphology, molecular responses assessed at 4 dpf. Exposure concentrations 0.1 μg/mL significantly increased bioaccumulation eye concentration-dependent manner disrupted system. These disruptions reduction eye-to-body length ratio decreased optomotor response positivity swimming distance, indicating impaired function behavior. Furthermore, elevated reactive oxygen species (ROS) levels, induced retinal apoptosis, gene expression related development (six6, pax2, pax6a, pax6b), apoptosis (tp53, casp3, bax, bcl2a), antioxidant defense (sod1, cat, gpx1a). mitigated these adverse effects, reducing restoring defenses, preserving function. highlights as against PSNP-induced dysfunction underlines urgent need address nanoplastic pollution protect aquatic ecosystems.

Язык: Английский

Combating micro/nano plastic pollution with bioplastic: Sustainable food packaging, challenges, and future perspectives

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125077 - 125077

Опубликована: Окт. 1, 2024

Язык: Английский