Effects of orally exposed SiO2 nanoparticles on lipid profiles in gut-liver axis of mice DOI Creative Commons

Kuanhang Li,

Zhengzheng Zhou, Yi Cao

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117580 - 117580

Опубликована: Дек. 20, 2024

Язык: Английский

Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish DOI Creative Commons

Ruike Wang,

Qi Zhang, Gang Chen

и другие.

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
A review on the combined toxicological effects of microplastics and their attached pollutants DOI Creative Commons

Mengzhen Li,

Wenhao Ma, James Kar‐Hei Fang

и другие.

Emerging contaminants, Год журнала: 2025, Номер unknown, С. 100486 - 100486

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Aflatoxin B1-induced hepatotoxicity through mitochondrial dysfunction, oxidative stress, and inflammation as central pathological mechanisms: A review of experimental evidence DOI Creative Commons

Tsholofelo P Moloi,

Khanyisani Ziqubu, Sithandiwe E. Mazibuko-Mbeje

и другие.

Toxicology, Год журнала: 2024, Номер 509, С. 153983 - 153983

Опубликована: Ноя. 2, 2024

Aflatoxin B

Язык: Английский

Процитировано

5
Organ-Specific Effects of Polystyrene Nanoplastics on Deltamethrin-Induced Toxicity in Mice: Mitigated Hepatorenal Oxidative Damage But Increased Enteric Toxicity DOI
Mengyuan Qi, Shengdong Zhang, Hua Fang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер 73(9), С. 5092 - 5101

Опубликована: Фев. 24, 2025

This study investigates the combined effects of polystyrene nanoplastics (PS-NPs) and deltamethrin (DEL) on mice, focusing their different impacts among organs. Mice were exposed to PS-NPs and/or DEL for 30 days. Results showed that alleviated DEL-induced oxidative damage in liver kidney by reducing its accumulation due decreased bioaccessibility. Conversely, increased intestine, leading enhanced susceptibility enteric infections caused bacteria, viruses, parasites, as indicated transcriptomic analysis. delayed excretion gastrointestinal motility, evidenced altered neurotransmitter levels, thereby contributing greater intestinal DEL. Moreover, 16S rDNA sequencing revealed tended decrease beneficial bacteria increase pathogenic gut microbiota, further heightening upon coexposure. The findings this shed new light complex health risks associated with coexposure pesticides.

Язык: Английский

Процитировано

0
Hsa_circ_0001944 Regulates FXR/TLR4 Pathway and Ferroptosis to Alleviate Nickel Oxide Nanoparticles-Induced Collagen Formation in LX-2 Cells DOI Creative Commons
Haodong Zhou,

Qingyang Chen,

Lijiao Ma

и другие.

Toxics, Год журнала: 2025, Номер 13(4), С. 265 - 265

Опубликована: Март 31, 2025

Nickel oxide nanoparticles (NiONPs) can induce liver fibrosis, and their mechanism may be related to non-coding RNA, nuclear receptor signal transduction ferroptosis, but the regulatory relationship between them is not clear. In this study, we aimed investigate role of hsa_circ_0001944 in regulating Farnesol X (FXR)/Toll-like 4 (TLR4) pathway ferroptosis NiONPs-induced collagen deposition. We observed decreased FXR expression, increased TLR4 expression alterations features both rat fibrosis LX-2 cell deposition model. To among FXR, treated cells with agonist (GW4064), inhibitor (TAK-242) (Erastin) combined NiONPs. The results showed that TAK-242 alleviated by increasing features. Furthermore, GW4064 reduced TLR4, indicated inhibited enhanced features, which were involved process induced Subsequently, predicted might regulate through bioinformatics analysis, found NiONPs cells. Overexpression level, summary, demonstrated regulates FXR/TLR4 alleviate formation

Язык: Английский

Процитировано

0
Association between microplastics exposure and depressive symptoms in college students DOI Creative Commons
Jing Luo, Song Lin

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 295, С. 118142 - 118142

Опубликована: Апрель 1, 2025

Microplastics (MP) are pervasive environmental pollutants that have raised concerns regarding their potential health effects. However, limited studies investigated the relationship between MP exposure and depression, particularly in college students. Our study aims to examine association depressive symptoms A total of 1420 students from Jiangsu College Nursing, China, were included this cross-sectional study. Depressive assessed using Patient Health Questionnaire-2 (PHQ-2), was estimated based on daily airborne concentration drinking-water levels. Multivariate logistic regression models used estimate associations symptoms. The prevalence among 61.8 %. median (interquartile range) 17403.7 (14174.8-20995.9) particles/day. Airborne exhibited positive with symptoms, while no significant found Compared participants lowest quartile exposure, those highest had 38 % higher odds experiencing (odds ratio [OR] = 1.38, 95 CI: 1.21-1.57). When treated as a continuous variable, each 1000-particle increase associated 7.0 (OR 1.07, 1.04-1.10). Stratified analyses indicated stronger male freshmen. This suggests is contributing factor for

Язык: Английский

Процитировано

0
Effects of orally exposed SiO2 nanoparticles on lipid profiles in gut-liver axis of mice DOI Creative Commons

Kuanhang Li,

Zhengzheng Zhou, Yi Cao

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117580 - 117580

Опубликована: Дек. 20, 2024

Язык: Английский

Процитировано

1