Lung Microbiome in Autoimmune-Associated Interstitial Lung Disease

Rheumatic Disease Clinics of North America, Год журнала: 2025, Номер 51(2), С. 201 - 212

Опубликована: Фев. 28, 2025

Язык: Английский

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Pulmonary Microbiota Affects Silica-Induced Pulmonary Fibrosis through Activation of the PI3K/AKT-Mediated Senescence in Alveolar Epithelial Cells

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138238 - 138238

Опубликована: Апрель 1, 2025

Язык: Английский

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Calprotectin inhibition attenuates silica-induced lung fibrosis

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 17, 2025

Язык: Английский

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PGC-1 alpha regulates mitochondrial biogenesis to promote silica-induced pulmonary fibrosis

Toxicology Research, Год журнала: 2025, Номер 14(3)

Опубликована: Май 2, 2025

Abstract Silicosis is an incurable chronic fibrotic lung disease caused by long-term exposure to respirable silica particles. It characterized persistent inflammation and progressive fibrosis of tissues, which eventually leads respiratory failure seriously affects human health. The high incidence mortality associated with silicosis have made the a widespread public health concern. However, its pathogenesis has not been fully elucidated. Mitochondrial biogenesis plays crucial role under various conditions. mechanism this process in still unclear. Therefore, study aimed explore influence PGC-1α gene on mitochondrial development silicosis. We established vivo vitro models exposing rats rat type-2 alveolar epithelial cells (RLE-6TN) silica. Our findings revealed alterations structure function, decreased biogenesis, reduced expression mtDNA (Mitochondrial DNA) content. By upregulating RLE-6TN cells, we activated PGC-1α- NRF1-TFAM signaling pathway, enhancing increasing citrate synthase content, improving mitigating fibrosis. results indicate that regulation can affect silicosis-induced fibrosis, highlighting significance progression

Язык: Английский

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Microbial Dysbiosis in the Lung and Gut in Response to Inhalable Particulate Matters in Pneumoconiosis Patients and Animals

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Pneumoconiosis is a progressive and life-threatening fibrotic lung disorder caused by the prolonged deposition of inhaled particulate matters (PMs); thus far, no cure available. Emerging evidence has suggested that resulting disordered respiratory microbiome disturbed architecture homeostasis responding to inhalable PMs. Lung dysbiosis also contributes injury distant organs, such as intestine, through lung-gut axis. Current studies on microbiome-disease interplay are still in their infancy, sufficient understanding microbial heterogeneity pathological processes lacking. Here we investigated gut patients with pneumoconiosis comparison healthy individuals. Our findings indicated reciprocal causation between injuries under particle exposure; pulmonary Streptococcus Stenotrophomonas, along intestinal Ligilactobacillus Blautia, may represent key communities influencing progression. We defined close microbiota crosstalk gut, evidenced interaction networks, implying considerable effects microenvironment either direct translocation or other mechanisms inflammation-driven alterations. Animal experiments further corroborated humans. Collectively, our results highlight potential involvement axis pathogenesis open new avenue develop microbiome-targeted diagnosis treatment strategies.

Язык: Английский

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A Network Pharmacology Approach-Based Decoding of Resveratrol's Anti-Fibrotic Mechanisms

Phytomedicine, Год журнала: 2024, Номер 135, С. 156092 - 156092

Опубликована: Сен. 28, 2024

Язык: Английский

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