Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies

Annales de Toxicologie Analytique, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease

Autophagy, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Microplastics (MPs) induce mitochondrial dysfunction and iron accumulation, contributing to macroautophagy/autophagy ferroptosis, which has increased susceptibility the exacerbation of chronic obstructive pulmonary disease (COPD); however, underlying mechanism remains unclear. We demonstrated that MPs intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis (ADF) vitro vivo. In lung tissues patients with COPD, concentrations MPs, especially polystyrene microplastics (PS-MPs), were significantly higher than control group, as detected pyrolysis gas chromatography mass spectrometry (Py-GCMS), accumulation. The exposure PS-MPs, 2 μm size, resulted their being deposited lungs model mice optical vivo imaging, observed bronchial epithelial cells traced GFP-labeled PS-MPs. There impairments accompanied reactive oxygen species (mito-ROS) overproduction levels lysosome biogenesis acidification pDHBE PS-MP stimulation, triggering occurrence ferritinophagy ADF triggered acute (AECOPD). Reestablishing via mitochondria-specific ROS scavenging or inhibition alleviated excessive ameliorated AECOPD induced Collectively, our data initially revealed exacerbate mito-ROS-mediated autophagy sheds light on further hazard assessments human respiratory health potential therapeutic agents for COPD.

Язык: Английский

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Tracing the Footprint of Microplastics: Transport Mechanism, Degradation, and Remediation in Marine Environment

Water Air & Soil Pollution, Год журнала: 2025, Номер 236(2)

Опубликована: Янв. 24, 2025

Язык: Английский

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A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis

Inhalation Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Фев. 11, 2025

In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic and terrestrial organisms. Findings revealed human lung tissues, raising concerns about potential role damaging tissue integrity contributing to pulmonary fibrosis-a chronic inflammatory condition characterized by scarring of epithelial tissues due accumulated extracellular matrix, triggered factors such alcohol, pathogens, genetic mutations, pollutants. this review, we explore both well-studied lesser-studied mechanisms signaling pathways, aiming shed light how might act mediators that activate distinct, often overlooked cascades. This review searched PubMed Google Scholar using keywords like "plastic," "microplastic," "lung fibrosis," "pulmonary system," "exposure route," "signaling pathways," combined "OR" "AND" singular plural forms. These pathways could not only induce damage but also play a development fibrosis. be targeted reduce microplastic-induced fibrosis, opening new avenues for future treatments.

Язык: Английский

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Micro- and Nano-Plastic-Induced Adverse Health Effects on Lungs and Kidneys Linked to Oxidative Stress and Inflammation

Life, Год журнала: 2025, Номер 15(3), С. 392 - 392

Опубликована: Март 3, 2025

Micro- and nano-plastics (MNPs) are small plastic particles that result from the breakdown of larger plastics. They widely dispersed in environment pose a threat to wildlife humans. MNPs present almost all everyday items, including food, drinks, household products. Air inhalation can also lead exposure MNPs. Research animals indicates once absorbed, they spread various organs, liver, spleen, heart, lungs, thymus, reproductive kidneys, even brain by crossing blood–brain barrier. Furthermore, MPs transport persistent organic pollutants or heavy metals invertebrates higher levels food chain. When ingested, additives monomers comprise disrupt essential biological processes human body, thereby leading disturbances endocrine immune systems. During 2019 coronavirus (COVID-19) pandemic, there was significant increase global use polypropylene-based face masks, insufficient waste management exacerbating pollution. This review examines existing research on impact MNP lung kidney health based vitro vivo studies. Over past decades, wide range studies suggest both tissues under healthy diseased conditions. Therefore, this emphasizes need for additional employing multi-approach analyses associated biomarkers mechanisms gain comprehensive precise understanding health.

Язык: Английский

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Simultaneous Determination of Six Common Microplastics by a Domestic Py-GC/MS

Atmosphere, Год журнала: 2025, Номер 16(4), С. 476 - 476

Опубликована: Апрель 19, 2025

Pyrolysis coupled with gas chromatography–mass spectrometry (Py-GC/MS) is a novel technology capable of detecting micro- and nanoplastics without size limit. However, the application Py-GC/MS to airborne microplastic analysis remains inconsistent. This study explores optimal procedures using domestic HenxiTM PY-1S pyrolyzer-based Py-GC/MS. The initial weight loss PVC occurs at approximately 260 °C, indicating that maximum thermal desorption temperature prior pyrolysis should not exceed 250 °C. To avoid interference from semi-volatile organics present in sample injected air, it essential purge pure helium elevated temperatures before pyrolysis. Microplastic standards can be prepared by ultrasonicating water–microplastic dispersion system. Significant interactions between mixtures were observed during co-pyrolysis, cannot ignored optimization quantitative references. procedure features good linearity (R2 > 0.98), low detection limit (0.06~0.0002 μg), acceptable precisions (RSD < 10% 8 days). Microplastics determined pyrolyzer GC/MS system are comparable those well-established PY-3030D-based Py-GC/MS, reliable powerful tool for analysis.

Язык: Английский

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Pulmonary Flora‐Derived Lipopolysaccharide Mediates Lung‐Brain Axis through Activating Microglia Involved in Polystyrene Microplastic‐Induced Cognitive Dysfunction

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract Microplastics (MPs) have been detected in the atmospheric and human respiratory system, indicating that tract is a significant exposure route for MPs. However, effect of inhaled MPs on cognitive function has not adequately studied. Here, C57BL/6 J mouse model inhalation to polystyrene (PS‐MPs, 5 µm, 60 d) established by intratracheal instillation. Interestingly, vivo fluorescence imaging transmission electron microscopy reveal PS‐MPs do accumulate brain. behavioral experiments shows mice impaired, accompanied histopathological damage lung brain tissue. Transcriptomic studies hippocampal tissue demonstrated key neuroplasticity factors as well deficits linked injury, respectively. Mechanistically, lung‐brain axis plays central role PS‐MPs‐induced neurological damage, pulmonary flora transplantation, lipopolysaccharide (LPS) intervention, cell co‐culture experiments. Together, reduces altering composition produce more LPS promoting M1 polarization microglia, which provides new insights into mechanism nerve caused also sheds light prevention neurotoxicity environmental pollutants.

Язык: Английский

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Genetic information supports a causal relationship between trace elements, inflammatory proteins, and COPD: evidence from a Mendelian randomization analysis

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 14, 2024

Objective Dietary factors and nutritional status may be among the risk for Chronic Obstructive Pulmonary Disease (COPD). There exists a certain correlation between trace elements COPD. Through Mendelian Randomization (MR) analysis, we investigated causal relationships elements, inflammatory proteins, Methods We employed MR, multivariable MR (MVMR), two-step (TSMR) approaches to assess links 15 COPD, with 91 proteins serving as mediators further elucidate tripartite relationships. Results Trace such Folate (OR = 1.293, 95%CI 1.027–1.628; p 0.029), Vitamin D 1.331, 1.071–1.654; 0.010), B12 1.424, 1.108–1.828; 0.006), Iron 0.741, 0.580–0.946; 0.016) demonstrated No relationship was observed in reverse MR. After adjusting BMI, 1.633, 1.098–2.429; 0.015), 0.507, 0.31–0.778; 0.001), 1.511, 1.029–2.217; 0.034) were identified independent whereas 1.118, 0.751–1.666; 0.581) not. Mediation analysis indicated that CDCP1 (5.76%) play mediating role Conclusion Folate, D, B12, have BMI adjustment, emerge factors. Furthermore, protein partially mediate offering scientific basis dietary recommendations could benefit COPD patients. The supplementation of advantageous individuals suffering from

Язык: Английский

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THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW

The Medical and Ecological Problems, Год журнала: 2024, Номер 28(3), С. 42 - 60

Опубликована: Дек. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Язык: Английский

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