Mechanisms underlying Th2-dominant pneumonia caused by plastic pollution derivatives (PPD): A molecular toxicology investigation that encompasses gut microbiomics and lung metabolomics
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
480, С. 136326 - 136326
Опубликована: Окт. 28, 2024
Язык: Английский
Protective immunity induced by a novel P1 adhesin C-terminal anchored mRNA vaccine against Mycoplasma pneumoniae infection in BALB/c mice
Microbiology Spectrum,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
ABSTRACT
Mycoplasma
pneumoniae
(Mp),
a
unique
pathogen
devoid
of
cell
wall,
is
naturally
impervious
to
penicillin
antibiotics.
This
bacterium
the
causative
agent
M.
pneumonia,
an
acute
pulmonary
affliction
marked
by
interstitial
lung
damage.
Non-macrolide
medications
may
have
potential
adverse
effects
on
developmental
trajectory
children,
thereby
establishing
macrolides
as
preferred
treatment
for
in
pediatric
patients.
However,
emergence
macrolide-resistant
and
multidrug-resistant
strains
presents
significant
challenges
clinical
management
public
health.
Vaccines,
particularly
those
based
mRNA
technology,
are
regarded
promising
avenue
preventing
controlling
infections
due
their
inherent
safety,
immunogenicity,
adaptability.
Our
research
delves
into
P1
adhesin
,
protein
that
binds
host
receptors
with
its
immunodominant
epitopes
located
at
carboxyl
terminus,
known
provoke
robust
immune
responses
inflammation.
We
developed
vaccine
harnessing
this
dominant
antigenic
epitope
assessed
protective
immunity
BALB/c
mice
against
infection.
The
elicited
potent
humoral
cellular
responses,
effectively
diminishing
It
notably
decreased
IL-6
levels
lungs
infected
concurrently
elevated
IL-4,
IL-10,
IFN-γ
post-immunization.
also
reduced
pathological
changes
DNA
copy
numbers
animals.
Collectively,
these
findings
underscore
vaccine’s
remarkable
immunogenicity
infections,
offering
valuable
insights
development
vaccines
targeting
mycoplasma
infections.
IMPORTANCE
bacteria
without
causing
pneumonia
resistant
penicillin.
increasing
prevalence
has
complicated
options,
emphasizing
need
new
strategies.
explores
candidate
targets
critical
bacteria’s
interaction
cells.
In
mouse
model,
shown
inducing
suggesting
possible
reduction
inflammation,
indicated
cytokine
pathology.
While
further
required,
preliminary
results
hint
direction
managing
future
therapeutic
development.
study
contributes
ongoing
search
effective
preventive
measures
.
Язык: Английский
Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 15, 2025
Fine
particulate
matter
2.5
(PM2.5)
is
a
prevalent
atmospheric
pollutant
that
closely
associated
with
asthma.
Elderly
patients
have
high
incidence
of
asthma
long
course
illness.
Our
previous
studies
revealed
exposure
to
PM2.5
diminishes
lung
function
and
exacerbates
damage
in
elderly
rats.
In
the
present
study,
we
investigated
whether
influences
susceptibility
allergic
Brown-Norway
rats
were
treated
ovalbumin
(OVA)
for
different
durations
before
after
exposure.
The
results
from
pulmonary
tests
histopathology
indicated
early
allergens
prior
increased
airway
hyperresponsiveness
led
severe
injury
asthmatic
Cytokine
microarray
analysis
demonstrated
majority
cytokines
chemokines
upregulated
OVA-treated
Cytological
examination
showed
no
change
eosinophil
(EOS)
counts,
yet
amounts
neutrophils
(NEU),
white
blood
cells
(WBC),
lymphocytes
(LYM),
monocytes
(MON)
lavage
fluid
significantly
higher
than
those
control
exposure,
suggesting
affects
noneosinophilic
ELISA
plasma
levels
IgG1,
IgE,
IgG2a
IgG2b
elevated
rats,
whereas
level
was
lower
OVA
compared
afterward.
A
non-targeted
metabolomic
identified
202
metabolites,
among
which
31
metabolites
differentially
abundant.
Ten
11
metabolic
pathways
uniquely
detected
Specifically,
there
positive
or
negative
correlations
between
Th2-associated
(IL-4,
IL-5,
IL-13)
six
group
IL-4
IL-5
negatively
correlated
five
findings
suggest
could
influence
response
potentially
through
changes
metabolites.
Язык: Английский
Role of environmental pollutants-induced ferroptosis in pulmonary diseases
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 24, 2025
Respiratory
diseases
rank
among
the
foremost
causes
of
mortality
and
disability
globally,
with
long-term
exposure
to
environmental
pollutants
playing
a
critical
role
in
their
onset
progression.
Despite
this,
underlying
mechanisms
effective
targeted
treatments
for
these
disorders
remain
poorly
understood,
highlighting
an
urgent
need
focused
research.
Cell
death,
programmed
cellular
response
external
harmful
stimuli,
including
ferroptosis-a
recently
identified
form
iron-dependent
cell
death-emerges
as
pivotal
process.
Characterized
by
intracellular
iron
accumulation
lipid
peroxidation,
ferroptosis
appears
intricately
linked
lung
injury
induced
pollutants.
This
review
examines
triggered
factors,
aiming
shed
light
on
its
specific
pathophysiological
potential
therapeutic
target.
By
deepening
our
understanding
interactions
between
pollution,
ferroptosis,
damage,
we
hope
inform
strategies
intervention.
Язык: Английский
Association between exposure to a mixture of dichlorophenol and parabens and lung function in adults from NHANES, 2007–2012
Heart & Lung,
Год журнала:
2025,
Номер
72, С. 32 - 41
Опубликована: Март 23, 2025
Язык: Английский
6PPD impairs immune responses and fin regeneration in zebrafish
Toxicology Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Co-exposure to microplastics enhances the allergenic potentials of house dust mite allergen Der p 1
Environmental Research,
Год журнала:
2025,
Номер
unknown, С. 121613 - 121613
Опубликована: Апрель 1, 2025
Язык: Английский
Polystyrene nanoplastics aggravate house dust mite induced allergic airway inflammation through EGFR/ERK-dependent lung epithelial barrier dysfunction
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
298, С. 118329 - 118329
Опубликована: Май 16, 2025
Язык: Английский
Microplastic Exposure Induces Preeclampsia-Like Symptoms via HIF-1α/TFRC-Mediated Ferroptosis in Placental Trophoblast Cells
Toxicology,
Год журнала:
2025,
Номер
516, С. 154197 - 154197
Опубликована: Май 23, 2025
Язык: Английский
THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW
The Medical and Ecological Problems,
Год журнала:
2024,
Номер
28(3), С. 42 - 60
Опубликована: Дек. 30, 2024
Airborne
microplastic
(NP)
and
nanoplastic
(MP)
pollution
has
emerged
as
a
pressing
environmental
concern
with
significant
implications
for
human
health.
While
MPs
are
present
both
indoors
outdoors,
indoor
concentrations
generally
higher
due
to
the
abrasion
of
household
materials,
furniture,
other
domestic
sources.
NPs,
when
inhaled,
accumulate
in
various
lung
regions,
exerting
toxic
effects
potentially
leading
respiratory
diseases.
This
systematic
review,
conducted
according
PRISMA
guidelines,
evaluates
recent
experimental
studies
on
pathogenic
impact
nanomicroplastics
(NMPs)
tissues
using
vivo
vitro
models.
The
review
included
10
analyzing
MP
accumulation
90
examining
pathogenetic
mechanisms
exposure.
Research
data
indicates
predominance
polymeric
fibers
such
polypropylene,
polyethylene
terephthalate,
polytetrafluoroethylene,
accounting
nearly
half
structures.
NMPs
exhibit
size-
composition-dependent
accumulation,
smaller
positively
charged
particles
showing
translocation
potential
systemic
circulation
organs.
highlights
synergistic
heavy
metals
pollutants,
interaction
pulmonary
surfactant,
role
exacerbating
Current
analysis
underscores
growing
interest
NMP-related
health
risks
identifies
knowledge
gaps,
including
need
standardization
NMP
toxicity
testing
further
exploration
biological
systems.
findings
emphasize
importance
mitigating
exposure
safeguard
pave
way
future
research
long-term
impacts
airborne
Язык: Английский