Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms
Hans Journal of Food and Nutrition Science,
Год журнала:
2025,
Номер
14(01), С. 23 - 29
Опубликована: Янв. 1, 2025
Язык: Английский
Micro-nanoplastics pollution and mammalian fertility: a systematic review and meta-analysis
Theriogenology,
Год журнала:
2025,
Номер
238, С. 117369 - 117369
Опубликована: Фев. 26, 2025
Язык: Английский
Impacts of iodoacetic acid on reproduction: current evidence, underlying mechanisms, and future research directions
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 3, 2024
In
light
of
the
undeniable
and
alarming
fact
that
human
fertility
is
declining,
harmful
factors
affecting
reproductive
health
are
garnering
more
attention.
Iodoacetic
acid
(IAA),
an
emerging
unregulated
drinking
water
disinfection
byproduct,
derives
from
chlorine
frequently
detected
in
environment
biological
samples.
Humans
ubiquitously
exposed
to
IAA
daily
mainly
through
water,
consuming
food
beverages
made
disinfected
contacting
swimming
pools
bath
etc.
Mounting
evidence
has
indicated
could
act
as
a
toxicant
bring
about
multifarious
adverse
damage.
For
instance,
it
can
interfere
with
gonadal
development,
weaken
ovarian
function,
impair
sperm
motility,
trigger
DNA
damage
germ
cells,
perturb
steroidogenesis,
The
underlying
mechanisms
predominantly
include
cytotoxic
genotoxic
effects
on
disturbance
hypothalamic-pituitary-gonadal
axis,
oxidative
stress,
inhibition
steroidogenic
proteins
or
enzymes,
dysbiosis
gut
microbiota.
Nevertheless,
there
still
some
knowledge
gaps
limitations
studying
potential
impact
reproduction,
which
urgently
need
be
addressed
future.
We
suppose
necessary
population
epidemiological
studies,
sensitive
detection
methods
for
internal
exposure,
mechanism-based
in-depth
exploration
will
contribute
comprehensive
understanding
characteristics
IAA,
thus
providing
important
scientific
basis
revising
sanitary
standards
quality.
Язык: Английский
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]‐humanin‐mediated attenuation of oxidative stress and ferroptosis
Andrology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
Abstract
Background
Oligoasthenozoospermia
is
a
common
cause
of
male
infertility,
for
which
effective
treatments
are
urgently
needed.
Humanin
(HN)
peptide
associated
with
this
condition.
Objectives
To
investigate
the
ameliorative
effect
[Gly14]‐Humanin
(HNG)
on
oligoasthenozoospermia
and
mechanisms.
Materials
methods
Mice
were
treated
cyclophosphamide
(CP)
to
construct
mice
model
oligoasthenozoospermia.
The
resulting
saline
or
HNG.
Subsequently,
testis
weights,
organ
indices,
testicular
structure,
sperm
counts
motilities,
litter
sizes,
serum
testosterone
concentrations
determined.
Differential
gene
expression
in
tissues
was
determined
by
RNA
sequencing.
TM3,
TM4,
GC1,
GC2
cells
exposed
erastin
induce
ferroptosis,
followed
treatment
HNG
+
ML385
(a
nuclear
factor
erythroid
2‐related
2
inhibitor).
Levels
reactive
oxygen
species
(ROS),
malondialdehyde
(MDA),
glutathione
(GSH),
ferrous
ions
(Fe
2+
)
their
ferroptosis‐related
proteins
immunofluorescence
western
blot.
Results
improved
parameters
increased
size
mice.
Kyoto
Encyclopaedia
Genes
Genomes
pathway
enrichment
analysis
revealed
significant
differential
genes.
after
treatment.
ROS,
MDA,
Fe
decreased
GSH
TM3
TM4
In
vitro
experiments
confirmed
that
activated
2/glutathione
peroxidase
4
(Nrf2/GPX4)
pathway.
However,
these
effects
blocked
Discussion
conclusion
demonstrated
therapeutic
mouse
reducing
oxidative
stress
ferroptosis.
cells,
attenuated
cellular
inhibited
ferroptosis
via
Nrf2/GPX4
Язык: Английский