Stress hyperglycemia ratio and machine learning model for prediction of all-cause mortality in patients undergoing cardiac surgery

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 15, 2025

The stress hyperglycemia ratio (SHR) was developed to reduce the effects of long-term chronic glycemic factors on levels, which associated with adverse clinical outcomes. This study aims evaluate relationship between postoperative SHR index and all-cause mortality in patients undergoing cardiac surgery. Data for this were extracted from Medical Information Mart Intensive Care IV (MIMIC-IV) database. Patients categorized into four groups based quartiles. primary outcome 30-day mortality, while secondary outcomes included in-hospital, 90-day 360-day mortality. analyzed using quartiles, Kaplan-Meier curves generated compare across groups. Cox proportional hazards regression restricted cubic splines (RCS) employed assess LASSO used feature selection. Six machine learning algorithms predict in-hospital further extended SHapley Additive exPlanations method visualizing model characteristics individual case predictions. A total 3,848 participants study, a mean age 68 ± 12 years female comprised 30.6% (1,179). Higher levels an increased risk as shown by (log-rank P < 0.05). analysis revealed that highest quartile significantly higher at these time points (P RCS demonstrated nonlinear relationships Naive Bayes achieves area under curve (AUC) predicting both (0.7936) (0.7410). In surgery, may serve valid tool assessing severity after surgery guiding treatment decisions.

Язык: Английский

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Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk

Environmental Research, Год журнала: 2024, Номер unknown, С. 120092 - 120092

Опубликована: Сен. 1, 2024

Язык: Английский

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Oxidative stress and inflammation mediate the adverse effects of cadmium exposure on all-cause and cause-specific mortality in patients with diabetes and prediabetes

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 29, 2025

The effect of cadmium exposure on mortality risk among individuals with diabetes and prediabetes remains unclear, particularly regarding potential mediation by oxidative stress inflammation. This study aimed to investigate the associations blood levels all-cause, cardiovascular disease (CVD), cancer mediating effects inflammation biomarkers in patients prediabetes. In this prospective cohort study, we analyzed 17,687 adults from National Health Nutrition Examination Survey (NHANES, 1999-2018). Nine related (gamma-glutamyl transferase [GGT], uric acid [UA], high-density lipoprotein [HDL], UA HDL ratio [UHR]) (neutrophil-lymphocyte [NLR], monocyte-lymphocyte [MLR], neutrophil-monocyte-lymphocyte [NMLR], systemic response index [SIRI], immune-inflammation [SII]) were systematically assessed. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) applied evaluate association risk. Generalized linear models used assess biomarkers, while regression RCS evaluated their mortality. Causal analysis identified biological pathways mediated Stratified sensitivity analyses further employed confirm robustness results. During 161,047.75 person-years follow-up, 3562 deaths occurred, including 1214 CVD 680 cancer. Higher associated increased risks all-cause (fully adjusted hazard [HR]: 2.17; 95% confidence interval [CI] 1.69-2.79, comparing highest vs. lowest quartile), (HR 2.06; CI 1.41-3.02), 2.38; 1.47-3.85), without evidence nonlinear relationship. Mediation indicated that UA, NLR, MLR, NMLR, SIRI partially mortality, although proportions relatively modest (ranging 1.4 4.8%). Additionally, GGT a small fraction Cadmium increases CVD, Oxidative appear mediate adverse effect. These findings emphasize urgent need for targeted interventions reduce cadmium-related risks. What is currently known about topic? linked are critical development complications. key research question? Does increase prediabetes? Are involved these effects? new? cause-specific associations. How might influence clinical practice? Monitor cadmium, stress,

Язык: Английский

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Systemic inflammatory biomarkers as mediators of the association between dietary flavonoids and sleep disorders in patients with hypertension: A population-based study

Journal of Functional Foods, Год журнала: 2025, Номер 128, С. 106788 - 106788

Опубликована: Апрель 11, 2025

Язык: Английский

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Associations between serum trace elements and biological age acceleration in the Chinese elderly: A community-based study investigating the mediating role of inflammatory markers and the moderating effect of physical activity

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138273 - 138273

Опубликована: Апрель 1, 2025

Язык: Английский

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Selenium alleviates cadmium-induced biological aging acceleration and the potential mediating role of inflammation

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 299, С. 118361 - 118361

Опубликована: Май 24, 2025

Язык: Английский

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Continuous exposure to low concentrations of antimony(III) induces inflammation, apoptosis, oxidative and endoplasmic reticulum stress in Caco-2 intestinal epithelial cells

Environmental Research, Год журнала: 2025, Номер unknown, С. 122001 - 122001

Опубликована: Май 1, 2025

Язык: Английский

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A cross-sectional study examining the relationship between the advanced lung cancer inflammation index and prostate cancer

Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)

Опубликована: Май 29, 2025

Язык: Английский

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A negative combined effect of exposure to maternal Mn-Cu-Rb-Fe metal mixtures on gestational anemia, and the mediating role of creatinine in the Guangxi Birth Cohort Study (GBCS): Twelve machine learning algorithms

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 300, С. 118418 - 118418

Опубликована: Май 31, 2025

Язык: Английский

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Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999–2002

Clinical Epigenetics, Год журнала: 2025, Номер 17(1)

Опубликована: Май 31, 2025

Currently, with the global aging of population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic affects CVD risk. This study included 404 patients 1941 non-CVD individuals from 1999-2002 National Health Nutrition Examination Survey cross-sectional data. Low-grade systemic was assessed using C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), response index (SIRI). Epigenetic age accelerations (EAAs) were calculated residuals between chronological ages: Horvath acceleration (AgeAccel), AgeAccelHannum, AgeAccelPheno. Weighted linear logistic regression analyzed associations exposures outcomes, mediating effects Sobel test. After adjusting confoundings, log-transformed NLR SIRI positively associated risk, odds (OR) ranges 1.260 1.354 (all P < 0.05). Furthermore, ln-transformed CRP AgeAccelHannum AgeAccelPheno, coefficient (β) 0.505 1.304 0.05); all three EAAs, β 0.392 2.212 0.005). Additionally, 1-unit increase AgeAccelPheno 2.8% (OR: 1.028, 95% CI 1.007-1.049, = 0.011) 3.5% 1.035, 1.014-1.056, 0.002) respectively. mediation analysis showed that mediates 10.44% (P 0.046) association risk; 24.03% 0.009) 18.16% 0.015) NLR-CVD SIRI-CVD risk associations, Our results demonstrate EAAs mediate highlighting potential multi-target approach modifications for personalized management reduce

Язык: Английский

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