High-Fat Diet and Altered Radiation Response
Biology,
Год журнала:
2025,
Номер
14(4), С. 324 - 324
Опубликована: Март 22, 2025
High-fat
diets
(HFDs)
have
become
increasingly
prevalent
in
modern
societies,
driving
rising
rates
of
obesity
and
metabolic
syndrome.
Concurrently,
radiation
exposure
from
medical
treatments
environmental
sources
poses
health
risks
shaped
by
both
biological
factors.
This
review
explores
the
intersection
between
HFDs
sensitivity/susceptibility,
focusing
on
how
diet-induced
alterations
influence
body’s
response
to
radiation.
Evidence
preclinical
clinical
studies
indicates
that
significantly
alter
metabolism,
leading
increased
oxidative
stress
immune
system
dysregulation.
These
changes
can
exacerbate
radiation-induced
stress,
inflammation,
DNA
damage,
potentially
increasing
sensitivity
normal
tissues.
Conversely,
HFD-induced
disruptions
may
activate
cellular
pathways
involved
repair,
cell
survival,
inflammatory
responses,
fostering
tumor
resistance
modifying
microenvironment,
which
impair
efficacy
therapy
cancer
treatment.
Understanding
interplay
diet
is
critical
for
optimizing
public
guidelines
improving
therapeutic
outcomes.
findings
underscore
need
further
research
into
dietary
interventions
mitigate
radiation-associated
risks.
Язык: Английский
Meta-Analysis of the Impact of Low-Dose Ionizing Radiation on Mortality and Progression of Heart Disease in the General Patient Population: Insights from Hormesis Theory in Cardiology
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(22), С. 6909 - 6909
Опубликована: Ноя. 16, 2024
Low-dose
ionizing
radiation
(LDIR)
is
commonly
used
in
medical
diagnoses
and
certain
professions,
but
its
long-term
effects
on
noncancer
diseases,
particularly
cardiovascular
disease
(CVD),
remain
uncertain.
While
LDIR
has
recognized
diagnostic
benefits,
influence
CVD
mortality
progression
still
debated,
with
some
suggesting
that
low
doses
may
even
have
beneficial
effects,
as
per
the
hormesis
theory.
Язык: Английский