Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117577 - 117577
Опубликована: Дек. 26, 2024
Язык: Английский
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Life, Год журнала: 2025, Номер 15(4), С. 573 - 573
Опубликована: Апрель 1, 2025
Per- and polyfluoroalkyl substances (PFASs) are among the persistent organic pollutants characterized by their persistence in environment, high mobility, adverse impact not only on ecosystem but also human health. The biggest challenges biomonitoring low concentrations of PFASs biological matrices presence matrix interferents samples. combination liquid chromatography with tandem mass spectrometry (LC-MS/MS) solid-phase extraction (SPE) as a sample preparation technique appears to be most suitable solution for achieving desired selectivity sensitivity PFAS determination. aim this review is describe possible sources PFASs, various matrices, analytical methods determining different using pretreatment techniques complex samples, well health risks associated exposure. studied include PFOA PFOS, which frequently detected such plasma, serum, breast milk. average range from 1.0 2.6 ng.mL−1 1.9 2.4 0.4 3.1 For were 2.0–4.0 ng.mL−1, 3.7–4.6 3.6–4.8 milk, respectively. significant effects exposure long-chain (such PFOS) lipid disorders, hypertension, diabetes mellitus, thyroid infertility, cancer, obesity, autism, neurodevelopmental issues, cardiovascular diseases, kidney liver disorders. It utmost importance monitor exposure, predict toxicity, develop effective strategies mitigate potential
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Май 9, 2025
Background Previous research indicates that per- and polyfluoroalkyl substances (PFAS) can disrupt metabolism neurological function via endocrine pathway interference neuroinflammation. These effects may impair melatonin secretion circadian rhythm regulation, suggesting potential links to sleep health. However, the impact of PFAS exposure on adolescent remains unclear. This study examines associations between health indicators in U.S. adolescents. Methods Data from 838 adolescents who participated 2005–2018 National Health Nutrition Examination Survey (NHANES) were analyzed investigate association physician-diagnosed disorders. Eight compounds identified. Multivariate logistic regression models, restricted cubic spline (RCS) curves, Bayesian kernel machine (BKMR), weighted quantile sum (WQS) used assess single, linear, combined Results Negative observed disorders three compounds, specifically perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), perfluorononanoic (PFNA). RCS analysis revealed a significant linear relationship ( P for non-linear > 0.05). The BKMR WQS models demonstrated effect disorders, with PFOS demonstrating most substantial contribution (effect size: 0.91). stratified had greater females [odds ratio (OR): 0.54, 95% confidence interval (CI): 0.33–0.87] than males (OR: 0.50, CI: 0.24–1.01), sex-specific differences vulnerability. Conclusions Our findings indicate negative correlation specific adolescents, being dominant component mixture stronger females. due cross-sectional nature study, causal cannot be established. results highlight public need further underlying mechanisms pathways future longitudinal or experimental studies.
Язык: Английский
Процитировано
0
American Journal of Otolaryngology, Год журнала: 2025, Номер 46(5), С. 104676 - 104676
Опубликована: Май 14, 2025
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Дек. 9, 2024
With the development of lifestyle, elevated uric acid and hyperuricemia have become important factors affecting human health, but biological mechanism risk are still unclear.
Язык: Английский
Процитировано
1
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117577 - 117577
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
0