The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia DOI Creative Commons
Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)

Опубликована: Май 1, 2025

Abstract Per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants. The neurotoxic cardiometabolic effects of PFAS well documented, leading to the hypothesis that exposure increases dementia risk. However, empirical data on in relation cognitive impairment weak, limited, inconsistent. This report reviews literature provides a rationale overview VascCog Longitudinal Study, new study using population‐based Northern Manhattan Study cohort, prospectively examine serum concentrations 13 lipids, carotid atherosclerosis, impairment, dementia. We hypothesize deleteriously impact cognition through pathway involving hyperlipidemia atherosclerosis. Rigorous examination is needed inform public health policies PFAS‐containing products, support regulations reduce community exposure, provide avenues protect at individual levels. Highlights risk factors neurotoxicity. Data controversial. mechanistic can policy.

Язык: Английский

Therapeutic intervention with anti-TNF alleviates colonic and hepatic toxicity induced by perfluorooctanoic acid (PFOA) DOI

Wei Li,

Yongjing Qian,

Xiaojing Cai

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 296, С. 118125 - 118125

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
Temporal and cross-sectional associations of serum per- and polyfluoroalkyl substances (PFAS) and lipids from 1986 to 2016 − The Tromsø study DOI Creative Commons

Ana Carolina M. F. Coêlho,

Dolley Charles, Therese Haugdahl Nøst

и другие.

Environment International, Год журнала: 2025, Номер 199, С. 109508 - 109508

Опубликована: Май 1, 2025

Per- and polyfluoroalkyl substances (PFAS) have been linked to effects on human lipid profiles, with several epidemiological studies reporting associations between specific PFAS blood concentrations. However, these inconsistent, most focused cross-sectional analyses limited repeated measurements. In this study, we investigated serum concentrations major classes over a 30-year period (1986-2016) up five time points. Lipids analyzed included total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), triglycerides (TG). This study 145 participants from The Tromsø Study, Norway, who donated plasma samples three times the period. Linear mixed-effects (LME) models assessed longitudinal classes, while multiple linear regression (MLR) were used for associations. LME demonstrated positive perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA), perfluorodecanoic (PFDA), perfluoroundecanoic (PFUnDA), perfluorododecanoic (PFDoDA), perfluorotridecanoic (PFTrDA) TC. Additionally, PFOA, PFDA, PFUnDA, PFDoDA, PFTrDA associated LDL-C, PFUnDA summed perfluorooctane sulfonate isomers (∑PFOS) HDL-C. Cross-sectional corroborated six compounds TC at least times, but LDL-C HDL-C not confirmed. Summed sulfonamide (∑PFOSA) showed negative association longitudinally, was confirmed cross-sectionally. No observed TG, longitudinally or Concentrations of positively lipids in analyses, consistent PFCA These findings highlight need further investigation into complex

Язык: Английский

Процитировано

0
The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia DOI Creative Commons
Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)

Опубликована: Май 1, 2025

Abstract Per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants. The neurotoxic cardiometabolic effects of PFAS well documented, leading to the hypothesis that exposure increases dementia risk. However, empirical data on in relation cognitive impairment weak, limited, inconsistent. This report reviews literature provides a rationale overview VascCog Longitudinal Study, new study using population‐based Northern Manhattan Study cohort, prospectively examine serum concentrations 13 lipids, carotid atherosclerosis, impairment, dementia. We hypothesize deleteriously impact cognition through pathway involving hyperlipidemia atherosclerosis. Rigorous examination is needed inform public health policies PFAS‐containing products, support regulations reduce community exposure, provide avenues protect at individual levels. Highlights risk factors neurotoxicity. Data controversial. mechanistic can policy.

Язык: Английский

Процитировано

0