MPs Entering Human Circulation through Infusions: A Significant Pathway and Health Concern
Environment & Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Human
uptake
of
microplastic
particles
(MPs)
is
causing
increasing
health
concerns,
and
there
mounting
pressure
to
evaluate
the
associated
risks.
While
MPs
can
be
ingested,
breathed
in,
or
drank
a
very
direct
entrance
channel
available
through
ingress
into
bloodstream.
Intravenous
infusion
usually
proceeds
from
plastic
bottles.
Many
are
made
polypropylene
(PP),
filtering
applied
limit
particle
contamination.
In
this
study,
we
examined
MPs'
content
filtrates
using
combination
surface-enhanced
Raman
spectroscopy
scanning
electron
microscopy.
We
find
that
number
PP
significant
(∼7500
particles/L).
The
MP
sizes
range
1
62
μm,
with
median
∼8.5
μm.
About
90%
ranged
between
20
μm
in
size,
∼60%
10
then
discuss
potential
such
injected
consequences
their
presence
highlight
organs
for
deposition,
possible
clinical
effects.
Our
quantitative
data
important
help
toxicity
risks
accurately
balance
those
versus
benefits
intravenous
injections.
Язык: Английский
Dust Fall Microplastics from a Megacity of China Inhibit Autophagy via the PI3K/Akt/mTOR Pathway
Environment & Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
The
problem
of
microplastics
(MPs)
pollution
has
caused
many
health
risks
to
residents
Chinese
cities.
In
this
study,
nine
kinds
MPs
or
microrubbers
(MRs)
from
dust
fall
(DF)
in
Xi'an,
a
megacity
northwestern
China,
were
measured
by
pyrolysis-gas
chromatography-mass
spectroscopy,
namely,
polyethylene,
polypropylene,
nylon
88,
polybutylene,
polytetrafluorethylene,
polyisoprene,
polyvinyl
chloride,
natural
rubber,
and
synthesis
rubber.
Here,
51.20%
extracted
the
original
DF
(samples
denoted
DF-O).
After
subtracting
procedure,
their
residual
(DF-S
samples)
divided
into
two
parts.
Our
results
indicated
that
DF-O
samples
exhibited
higher
cytotoxicity,
inflammatory,
oxidative
stress
levels
than
DF-S
did.
suppressed
autophagy
decreasing
expression
microtubule-associated
protein
light
chain
3
(LC3B),
p-phosphatidylinositol
3-kinase
(p-PI3K),
phosphorylated
AKT
(p-Akt),
p-mammalian
target
rapamycin
(p-mTOR)
while
increasing
level
p62.
Meanwhile,
induced
apoptosis
through
Bax/Bcl-2
Cleaved
Caspase-3/Caspase-3
Raw264.7
cells.
These
trends
could
be
reversed
removing
half
DF-O.
Therefore,
inhibited
via
activating
PI3K/Akt/mTOR
pathway,
ratios.
Here
we
provide
comprehensive
perspective
studies
atmospheric
status
mechanisms
inhalation
toxicity
for
risk
assessment
DF.
Язык: Английский
Microplastics in the Amur tiger's habitat: Occurrence, characteristics, and risk assessment
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
493, С. 138380 - 138380
Опубликована: Апрель 23, 2025
Microplastics
(MPs)
are
emerging
environmental
pollutants
that
pose
a
significant
threat
to
wildlife
within
forest
ecosystems.
However,
the
quantity
and
types
of
MPs
in
habitats
remain
unclear.
This
study
is
first
assess
distribution
Amur
tiger
habitat
northeast
China.
Our
results
showed
were
detected
soil,
water,
atmosphere,
forage
plants,
ungulate
top
predator
feces
ecosystem,
respectively.
The
average
diameter
all
was
44.99
±
34.80μm.
predominant
polymers
found
samples
polyamide,
polyvinyl
chloride,
polyurethane.
Certain
sample
shared
similar
MP
polymer
type
distributions,
indicating
potential
links
their
sources
transfer
pathways.
Consequently,
these
findings
provide
some
new
insights
on
pollution
problem
prompt
us
consider
how
control
manage
conservation.
Язык: Английский