Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action

Antioxidants, Год журнала: 2025, Номер 14(4), С. 389 - 389

Опубликована: Март 26, 2025

The skin, as the largest external organ, is exposed to many environmental factors, such sunlight and pollution, well some synthetic ingredients in cosmetic products used excess by most people of all ages throughout their lives. Under influence these factors with age, amount key building protein, collagen type I, decreases, which leads a deterioration appearance condition skin. Currently, when average life expectancy increases, esthetic aspect maintaining healthy skin are particularly important. In pharmaceutical industries, attempts have long been made prevent aging application containing natural compounds, mainly due high antioxidant activity. This review collects polyphenols, stimulating protective effects on I human fibroblasts, along description mechanisms action. Some them tested mice rats, clinical trials, cases, results very promising. Nevertheless, there still need for an intensification studies order determine appropriate dosage, safety, effectiveness.

Язык: Английский

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Evaluating paraben concentrations in skincare products and assessing their potential health risks

Journal of Environmental Exposure Assessment, Год журнала: 2025, Номер 4(1)

Опубликована: Янв. 3, 2025

There is a lack of specific regulations in Saudi Arabia governing the use potentially hazardous compounds, such as parabens, skincare products (SCPs). This study analyzed 111 feminine SCPs used for presence selected parabens [namely methylparaben (MeP), ethylparaben (EtP), and propylparaben (PrP)] to assess their health risks. These were highly prevalent examined SCPs; MeP was most common, followed by PrP. However, we noted that ≈14% paraben-free. Nine contained MeP, EtP, PrP concentrations exceeding European Union Regulation 1223/2009 limits. The estimated daily paraben intake via dermal exposure calculated. combined maximum (EDI) EtP remarkably lower than acceptable (ADI) limit set Food Safety Authority (EFSA); however, levels 23% exceeded recommended ADI limit. Although average hazard index (HI) below safety threshold, 26 had HI > 1, indicating potential risk primarily due margin (MOE) values calculated these did not reach benchmark EFSA. In conclusion, tested pose relatively low risk; content many raises concerns, especially considering cumulative multiple parabens. underscores need monitor regulate ensure consumer safety.

Язык: Английский

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Assessment of the toxic effects of parabens, commonly used preservatives in cosmetics, and their halogenated by-products on human skin and endothelial cells

NAM journal., Год журнала: 2025, Номер unknown, С. 100011 - 100011

Опубликована: Янв. 1, 2025

Язык: Английский

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Exploring the binding mechanism of parabens to transthyretin: An integrated analysis using multi-spectral and computational simulation techniques

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 339, С. 126265 - 126265

Опубликована: Апрель 18, 2025

Язык: Английский

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Endocrine disruptors in personal care products and cosmetics: Sample preparation and analysis- evaluation of green and blue characteristics

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113769 - 113769

Опубликована: Апрель 1, 2025

Язык: Английский

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Dietary exposure to environmental phenols and phthalates in Korean adults: data analysis of the Korean National Environmental Health Survey (KoNEHS) 2018–2020

International Journal of Hygiene and Environmental Health, Год журнала: 2025, Номер 267, С. 114597 - 114597

Опубликована: Май 19, 2025

Язык: Английский

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Human endocrine disruption: an updated review of toxicological insights into parabens and phthalates

Toxicology and Environmental Health Sciences, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Язык: Английский

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